2025
Association between three-dimensional right ventricular ejection fraction and in-hospital outcomes in patients undergoing cardiac surgery. A multicenter study
Posada-Martinez E, Ivey-Miranda J, Ortiz-Leon X, Arias-Godinez J, Fritche-Salazar J, Rodriguez-Zanella H, Ruiz Esparza-Dueñas M, Romero-Zertuche D, Silvestre-Flores I, Morales-Portano J, Orea-Tejeda A, Rojas-Serrano J, McNamara R, Reyes Lopez P, Sugeng L. Association between three-dimensional right ventricular ejection fraction and in-hospital outcomes in patients undergoing cardiac surgery. A multicenter study. Journal Of The American Society Of Echocardiography 2025 PMID: 39984139, DOI: 10.1016/j.echo.2025.02.008.Peer-Reviewed Original ResearchRight ventricular ejection fractionRV function parametersVentricular ejection fractionCardiac surgeryEuroSCORE IIPrimary outcomeEjection fractionMechanical ventilationMulticenter study of adult patientsRight ventricular (RV) functionParameters of RV systolic functionPredictors of in-hospital mortalityStudy of adult patientsFunction parametersRV systolic functionProspective multicenter studyAssociated with shorter timeAccurate risk stratificationEvaluation of patientsIn-hospital mortalityIn-hospital outcomesTemporary ventricular assist devicesTransesophageal echocardiogramExploratory endpointsPrimary endpointArtificial intelligence-guided detection of under-recognised cardiomyopathies on point-of-care cardiac ultrasonography: a multicentre study
Oikonomou E, Vaid A, Holste G, Coppi A, McNamara R, Baloescu C, Krumholz H, Wang Z, Apakama D, Nadkarni G, Khera R. Artificial intelligence-guided detection of under-recognised cardiomyopathies on point-of-care cardiac ultrasonography: a multicentre study. The Lancet Digital Health 2025, 7: e113-e123. PMID: 39890242, DOI: 10.1016/s2589-7500(24)00249-8.Peer-Reviewed Original ResearchConceptsYale New Haven Health SystemPoint-of-care ultrasonographyMount Sinai Health SystemTransthyretin amyloid cardiomyopathyArtificial intelligenceHealth systemAmyloid cardiomyopathyHypertrophic cardiomyopathyRetrospective cohort of individualsCardiomyopathy casesTesting artificial intelligenceConvolutional neural networkSinai Health SystemCohort of individualsOpportunistic screeningHypertrophic cardiomyopathy casesMulti-labelPositive screenAI frameworkEmergency departmentMortality riskNeural networkLoss functionCardiac ultrasonographyAugmentation approachThree-dimensional right ventricular ejection fraction: a strong predictor of outcomes in patients undergoing cardiac surgery, a multicenter study.
Posada-Martinez E, Ivey-Miranda J, Ortiz-Leon X, Arias-Godinez J, Fritche-Salazar J, Rodriguez-Zanella H, Esparza M, Romero-Zertuche D, Silvestre-Flores I, Morales-Portano J, Mcnamara R, Sugeng L. Three-dimensional right ventricular ejection fraction: a strong predictor of outcomes in patients undergoing cardiac surgery, a multicenter study. European Heart Journal - Cardiovascular Imaging 2025, 26: jeae333.356. DOI: 10.1093/ehjci/jeae333.356.Peer-Reviewed Original ResearchLower RV ejection fractionRV ejection fractionCardiac surgeryPredictors of outcomePrimary outcomeEjection fractionMulticenter studyMechanical ventilationRight ventricular (RV) functionCohort study of adult patientsLeft ventricular ejection fractionRV-pulmonary arterial couplingComposite of in-hospital mortalityMultivariate Cox regression modelStudy of adult patientsBackground Cardiac surgeryAortic valve repairRV function parametersVentricular ejection fractionAssociated with shorter timeEvaluation of patientsAssociated with in-hospital outcomesBaseline demographic characteristicsTomTec Imaging SystemsIn-hospital mortalityElevated Systolic Blood Pressure and Hemodynamic Parameters in Patients with Aortic Stenosis Undergoing Echocardiography in Real-World Practice
Singh J, Reinhardt S, Hur D, Sugeng L, Akintoye E, Lombo B, Bellumkonda L, Shkolnik E, McNamara R, Faridi K. Elevated Systolic Blood Pressure and Hemodynamic Parameters in Patients with Aortic Stenosis Undergoing Echocardiography in Real-World Practice. Journal Of The American Society Of Echocardiography 2025 PMID: 39884444, DOI: 10.1016/j.echo.2025.01.010.Peer-Reviewed Original Research
2024
Deep-learning generated B-line score mirrors clinical progression of disease for patients with heart failure
Baloescu C, Chen A, Varasteh A, Hall J, Toporek G, Patil S, McNamara R, Raju B, Moore C. Deep-learning generated B-line score mirrors clinical progression of disease for patients with heart failure. The Ultrasound Journal 2024, 16: 42. PMID: 39283362, PMCID: PMC11405569, DOI: 10.1186/s13089-024-00391-4.Peer-Reviewed Original ResearchB-line scoreComposite congestion scoreCongestion scoreHeart failureSeverity scoreB-linesCongestive heart failurePatients suspectedPulmonary congestionLung zonesClinical progressionRothman IndexClinical assessmentDisease severityPatientsPresence of artifactsEvaluate changesLungDetect fluidUltrasound experienceMixed effects modelsScoresDiseaseInterstitial spaceUltrasound systemResidual Ultrasound-Enhancing Agents Mimicking Portal Venous Gas
Bitar R, Langdon J, Kaur M, Crandall I, McNamara R, Revzin M. Residual Ultrasound-Enhancing Agents Mimicking Portal Venous Gas. Ultrasound Quarterly 2024, 40: e00694. PMID: 39466239, DOI: 10.1097/ruq.0000000000000694.Peer-Reviewed Original ResearchConceptsUltrasound enhancing agentsPortal venous gasBowel ischemiaAbdominal ultrasoundVenous gasEchogenic fociContrast-enhanced echocardiographyEvaluation of cardiac functionPortal venous systemSeries of casesSonographic detectionCardiac functionDifferential diagnosisPortal veinVenous systemObservational studyLiver parenchymaPortal triadsVascular patencyBowelIschemiaEchocardiographyLiverUltrasoundA Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.Peer-Reviewed Original ResearchCardiac magnetic resonanceAortic valve replacementCardiac magnetic resonance imagingAV VmaxSevere ASAortic stenosisCohort studyPeak aortic valve velocityCohort study of patientsAortic valve velocityCohort of patientsTraditional cardiovascular risk factorsAssociated with faster progressionStudy of patientsCedars-Sinai Medical CenterAssociated with AS developmentCardiovascular risk factorsCardiovascular imaging modalitiesIndependent of ageModerate ASEjection fractionEchocardiographic studiesValve replacementRisk stratificationCardiac structureHigh- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT?
See C, Kim Y, Park J, Wang Y, Reinhardt S, Shkolnik E, Faridi K, Lombo B, Bellumkonda L, McNamara R, Sugeng L, Hur D. High- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT? International Journal Of Cardiology 2024, 409: 132174. PMID: 38754590, DOI: 10.1016/j.ijcard.2024.132174.Peer-Reviewed Original ResearchNormal-flow low-gradientAortic valve areaTranscatheter AV replacementParadoxical low-flow low-gradientCardiovascular CTTransthoracic echocardiogramCalcium scoreAS patientsDiagnosis of severe ASLow-gradient aortic stenosisHG-AS patientsLG-AS patientsLow-flow low-gradientAorto-mitral angleAortic valve (AV) stenosisLG-ASPLFLG-ASAV replacementSevere ASConsecutive patientsAortic stenosisValve areaAS phenotypeClinical managementEchocardiogramUltrasound evaluation of portal venous gas and its mimics
Bitar R, Kaur M, Crandall I, McNamara R, Revzin M. Ultrasound evaluation of portal venous gas and its mimics. Abdominal Radiology 2024, 49: 2756-2769. PMID: 38735019, DOI: 10.1007/s00261-024-04328-2.Peer-Reviewed Original ResearchFactors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice
Faridi K, Zhu Z, Shah N, Crandall I, McNamara R, Flueckiger P, Bachand K, Lombo B, Hur D, Agarwal V, Reinhardt S, Velazquez E, Sugeng L. Factors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice. Echocardiography 2024, 41: e15774. PMID: 38329886, DOI: 10.1111/echo.15774.Peer-Reviewed Original ResearchConceptsTransthoracic echocardiogramVentricular ejection fractionOutpatient transthoracic echocardiogramsReal-world practiceEjection fractionLeft ventricular ejection fractionAssess left ventricular ejection fractionInpatient transthoracic echocardiogramsMultivariate logistic regressionLVEFHospitalized patientsMedical CenterSonographersClinical settingLogistic regressionUltrasound machineChemotherapyContrast enhancement agentsPortable studiesNegative association
2023
Variation in Reader-Reported Severity of Paradoxical Low-Flow Low-Gradient Aortic Stenosis
Shah N, Sugeng L, Zhang Z, Wang K, McNamara R, Agarwal V, Hur D, Lombo B, Bellumkonda L, Mankbadi M, Basem Dajani A, Forrest J, Krumholz H, Reinhardt S, Velazquez E, Faridi K. Variation in Reader-Reported Severity of Paradoxical Low-Flow Low-Gradient Aortic Stenosis. Journal Of The American Society Of Echocardiography 2023, 37: 466-467. PMID: 37995937, DOI: 10.1016/j.echo.2023.11.014.Peer-Reviewed Original ResearchPredicting aortic stenosis progression using a video-based deep learning model of aortic stenosis built for single-view two-dimensional echocardiography
Oikonomou E, Holste G, Mcnamara R, Velazquez E, Nadkarni G, Ouyang D, Krumholz H, Wang Z, Khera R. Predicting aortic stenosis progression using a video-based deep learning model of aortic stenosis built for single-view two-dimensional echocardiography. European Heart Journal 2023, 44: ehad655.040. DOI: 10.1093/eurheartj/ehad655.040.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSevere aortic stenosisAortic stenosisAS progressionAV VmaxTransthoracic echocardiographyYale New Haven Health SystemBaseline left ventricular ejection fractionAortic stenosis progressionModerate aortic stenosisRetrospective cohort studyVentricular ejection fractionTwo-dimensional echocardiographyMean rateModerate ASAS severityCohort studyEjection fractionPatient sexStenosis progressionTTE studiesEligible participantsSerial monitoringSpecialized centersTimely diagnosisSevere aortic stenosis detection by deep learning applied to echocardiography
Holste G, Oikonomou E, Mortazavi B, Coppi A, Faridi K, Miller E, Forrest J, McNamara R, Ohno-Machado L, Yuan N, Gupta A, Ouyang D, Krumholz H, Wang Z, Khera R. Severe aortic stenosis detection by deep learning applied to echocardiography. European Heart Journal 2023, 44: 4592-4604. PMID: 37611002, PMCID: PMC11004929, DOI: 10.1093/eurheartj/ehad456.Peer-Reviewed Original ResearchTwo‐ Versus 8‐Zone Lung Ultrasound in Heart Failure: Analysis of a Large Data Set Using a Deep Learning Algorithm
Baloescu C, Chen A, Varasteh A, Toporek G, McNamara R, Raju B, Moore C. Two‐ Versus 8‐Zone Lung Ultrasound in Heart Failure: Analysis of a Large Data Set Using a Deep Learning Algorithm. Journal Of Ultrasound In Medicine 2023, 42: 2349-2356. PMID: 37255051, DOI: 10.1002/jum.16262.Peer-Reviewed Original ResearchConceptsHeart failureLung ultrasoundBland-Altman plot analysisSubgroup analysisUltrasound protocolMore lung zonesProspective observational studyReal-world clinical useB-linesAdult patientsLung zonesObservational studyClinical useScanning protocolVideo loopsPatientsPlot analysisRate severityUltrasoundAverage severitySeverityScoresTwo- VersusFailureSeverity informationTHE INCIDENCE OF CHAGAS CARDIOMYOPATHY IN A NORTHWESTERN COMMUNITY OF CÓRDOBA, ARGENTINA
Martinez M, Amuchastegui M, Grima J, Amuchastegui T, Alvarellos T, McNamara K, Garimella S, Sánchez A, Mankbadi M, Sewanan L, Salomone O, McNamara R, Lombo B. THE INCIDENCE OF CHAGAS CARDIOMYOPATHY IN A NORTHWESTERN COMMUNITY OF CÓRDOBA, ARGENTINA. Journal Of The American College Of Cardiology 2023, 81: 553. DOI: 10.1016/s0735-1097(23)00997-x.Peer-Reviewed Original Research
2022
Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis
Bregasi A, Freeman JV, Curtis JP, Akar JG, Ortiz-Leon XA, Maia JH, Higgins AY, Matthews RV, Sinusas AJ, McNamara RL, Sugeng L, Lin BA. Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis. AJP Heart And Circulatory Physiology 2022, 323: h559-h568. PMID: 35960632, PMCID: PMC9576173, DOI: 10.1152/ajpheart.00083.2022.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionLA stiffnessAppendage occlusionLA appendageLA mechanicsTransesophageal echocardiographyPressure-volume analysisPercutaneous left atrial appendage occlusionAdverse atrial remodelingAtrial appendage occlusionLeft atrial appendageLA volume measurementsAtrial cardiomyopathyBaseline characteristicsLA complianceAtrial remodelingClinical outcomesAtrial appendageAtrial mechanicsCardiac performancePathophysiological roleBaseline parametersMagnitude of increaseAppendage sizeOcclusion
2021
IN-HOSPITAL MORTALITY RISK PREDICTION FOR PERCUTANEOUS CORONARY INTERVENTIONS: AN UPDATED MODEL FROM THE NCDR CATHPCI REGISTRY
Dominguez Y, Minges K, Wang Y, McNamara R, Spertus J, Dehmer G, Messenger J, Mercado N, Lavin K, Pierre D, Anderson C, Blankinship K, Clary J, Osborne A, Curtis J, Cavender M. IN-HOSPITAL MORTALITY RISK PREDICTION FOR PERCUTANEOUS CORONARY INTERVENTIONS: AN UPDATED MODEL FROM THE NCDR CATHPCI REGISTRY. Journal Of The American College Of Cardiology 2021, 77: 1217. DOI: 10.1016/s0735-1097(21)02576-6.Peer-Reviewed Original Research
2020
2020 Update to the 2016 ACC/AHA Clinical Performance and Quality Measures for Adults With Atrial Fibrillation or Atrial Flutter: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures
Members W, Heidenreich P, Estes N, Fonarow G, Jurgens C, Kittleson M, Marine J, McManus D, McNamara R. 2020 Update to the 2016 ACC/AHA Clinical Performance and Quality Measures for Adults With Atrial Fibrillation or Atrial Flutter: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Circulation Cardiovascular Quality And Outcomes 2020, 14: e000100. PMID: 33284642, DOI: 10.1161/hcq.0000000000000100.Peer-Reviewed Original ResearchTRICUSPID AND MITRAL REMODELING IN ATRIAL FIBRILLATION: A THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY
Ortiz-Leon X, Posada E, Trejo M, Miranda J, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Houle H, Akar J, Lin B, McNamara R, Lombo B, Arias-Godínez J, Sugeng L. TRICUSPID AND MITRAL REMODELING IN ATRIAL FIBRILLATION: A THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY. Journal Of The American College Of Cardiology 2020, 75: 1706. DOI: 10.1016/s0735-1097(20)32333-0.Peer-Reviewed Original ResearchCHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY
Ortiz-Leon X, Posada E, Chen W, Bregasi A, Crandall I, Pereira J, Miranda J, Akar J, Lin B, McNamara R, Freeman J, Curtis J, Arias-Godínez J, Sugeng L. CHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY. Journal Of The American College Of Cardiology 2020, 75: 1708. DOI: 10.1016/s0735-1097(20)32335-4.Peer-Reviewed Original Research