Cytoplasmic Intron Retention As a Regulatory Mechanism of Mitochondrial Homeostasis in Erythroid Cells
Roy R, Boddu P, Pillai M. Cytoplasmic Intron Retention As a Regulatory Mechanism of Mitochondrial Homeostasis in Erythroid Cells. Blood 2024, 144: 1075-1075. DOI: 10.1182/blood-2024-211280.Peer-Reviewed Original ResearchNonsense-mediated decayIntron retentionRetained intronsCry transcriptsSplicing factorsRI transcriptionFunctional genomics dataLong-read sequencingAbsence of intronsErythroid cellsENCODE consortiumPolyadenylated RNAGenomic dataRNA-seqHUDEP-2 cellsMRNA processingNuclear exportCRISPR deletionMitochondrial homeostasisProtein isoformsRNA abundanceUnspliced RNAIntronStages of erythropoiesisPeptide translationA Unified Post-Transcriptional Mechanism Regulates Intron Retention in Splicing Factor-Mutant MDS
Boddu P, Roy R, Baumgartner F, Hutter S, Haferlach T, Pillai M. A Unified Post-Transcriptional Mechanism Regulates Intron Retention in Splicing Factor-Mutant MDS. Blood 2024, 144: 2732-2732. DOI: 10.1182/blood-2024-211458.Peer-Reviewed Original ResearchRNA-binding proteinsIntron retentionAlternative splicing patternsPost-transcriptional mechanismsIR eventsSF mutationsSR proteinsSF3B1 mutantsAnalyzed RNA-seq datasetsMyelodysplastic syndromeCo-transcriptional splicingCo-transcriptional mechanismsRNA-seq datasetsPost-transcriptional splicingWild-typeSub-compartmentsNuclear sub-compartmentsHEK293T cellsGene expression analysisWild-type K562 cellsRNA processingMutant cellsPhospho-proteomicsExon featuresAS events