Nachshon Korem
Associate Research Scientist in PsychiatryCards
About
Research
Publications
2025
Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkModeling decision-making under uncertainty with qualitative outcomes.
Korem N, Duek O, Jia R, Wertheimer E, Metviner S, Grubb M, Levy I. Modeling decision-making under uncertainty with qualitative outcomes. PLOS Computational Biology 2025, 21: e1012440. PMID: 40029903, PMCID: PMC11918403, DOI: 10.1371/journal.pcbi.1012440.Peer-Reviewed Original ResearchMEMORY RELATED STRUCTURAL AND FUNCTIONAL NEURAL CHANGES FOLLOWING A SINGLE INFUSION OF KETAMINE IN PTSD
Harpaz-Rotem *, Duek O, Korem N, Krystal J. MEMORY RELATED STRUCTURAL AND FUNCTIONAL NEURAL CHANGES FOLLOWING A SINGLE INFUSION OF KETAMINE IN PTSD. The International Journal Of Neuropsychopharmacology 2025, 28: i38-i38. PMCID: PMC11814760, DOI: 10.1093/ijnp/pyae059.066.Peer-Reviewed Original ResearchPost-retrieval extinctionInfusion of ketamineIntravenous infusion of ketamineTrauma memoriesTraumatic memoriesFear responsesSs' responsesAssociated with decreased connectivityAmygdala-vmPFC connectivityTrauma-focused psychotherapyTreatment of PTSDNMDA receptor antagonistPre-post treatmentAmygdala activationLower amygdalaReconsolidation windowUncinate fasciculusAssessed before treatmentKetamine administrationMemory learningNaturalistic stimuliLabile stateAmygdalaPTSDExtinction process
2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchPost-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT
Korem N, Duek O, Ben-Zion Z, Spiller T, Gordon C, Amen S, Levy I, Harpaz-Rotem I. Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT. Psychiatry Research Neuroimaging 2024, 343: 111864. PMID: 39111111, DOI: 10.1016/j.pscychresns.2024.111864.Peer-Reviewed Original ResearchReduced resting-state functional connectivityPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional connectivityPost-treatment changesReducing PTSD symptom severityFollow-up changesResting-state functional connectivityIntensive exposure therapyExposure-based psychotherapyVentromedial prefrontal cortexPTSD symptom severityReduced structural connectivityFunctional connectivity patternsPost-treatmentWhite matter integrityPrefrontal cortexExposure therapyPTSD symptomsStress disorderSymptom severityUncinate fasciculusLimbic systemSecondary analysisAssociated with sustained changes351. High-Threshold-Low-Tolerance: A Model for the Emotionality Paradox in PTSD
Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. 351. High-Threshold-Low-Tolerance: A Model for the Emotionality Paradox in PTSD. Biological Psychiatry 2024, 95: s243. DOI: 10.1016/j.biopsych.2024.02.850.Peer-Reviewed Original ResearchEmotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder
Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. Emotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder. JAMA Network Open 2024, 7: e246813. PMID: 38625701, PMCID: PMC11022112, DOI: 10.1001/jamanetworkopen.2024.6813.Peer-Reviewed Original ResearchPosttraumatic stress disorderTrauma-exposed individualsEmotional numbing symptomsTrauma-exposed controlsNegative emotional statesNumbing symptomsEmotional numbingDSM-5Valence ratingsStress disorderEmotional statesTrauma-exposed control groupPTSD experiencesPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistDSM-5 criteriaAge-related associationsStimulus valencePCL-5Emotional responsesEmotional state transitionEmotional transitionSymptomsParticipantsDisorders
2023
Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study
Danböck S, Duek O, Ben-Zion Z, Korem N, Amen S, Kelmendi B, Wilhelm F, Levy I, Harpaz-Rotem I. Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study. Psychopharmacology 2023, 241: 243-252. PMID: 37872291, PMCID: PMC10806226, DOI: 10.1007/s00213-023-06479-4.Peer-Reviewed Original ResearchResting-state functional connectivityPosttraumatic stress disorderFunctional magnetic resonance imagingMedial prefrontal cortexMPFC subregionsAnterior medial PFCFunctional connectivityStress disorderAspartate glutamate receptor antagonistPilot studyNon-competitive N-methylGlutamate receptor antagonistsEffects of ketamineDissociative drugsMagnetic resonance imagingIntravenous drug infusionReceptor antagonistSubanesthetic doseDrug infusionCorrelative findingsKetamineResonance imagingTransient decreaseDrug midazolamAmygdalaStructural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review
Ben-Zion Z, Korem N, Fine N, Katz S, Siddhanta M, Funaro M, Duek O, Spiller T, Danböck S, Levy I, Harpaz-Rotem I. Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review. Biological Psychiatry Global Open Science 2023, 4: 120-134. PMID: 38298789, PMCID: PMC10829655, DOI: 10.1016/j.bpsgos.2023.07.001.Peer-Reviewed Original ResearchPost-traumatic stress disorderAmygdala subregionsStress disorderKey limbic regionsEtiology of PTSDPosttraumatic stress disorderDentate gyrusLimbic regionsSubiculum volumeSubregion volumesHippocampal subregionsDisorder pathogenesisStructural neuroimagingAutomatic segmentation softwareAmygdalar subregionsHippocampusNucleus volumeScoping ReviewPathogenesisCurrent literatureDisordersSegmentation softwareMethodological limitationsPost-traumatic psychopathologyReviewCorrelates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Korem N, Ben-Zion Z, Spiller T, Duek O, Harpaz-Rotem I, Pietrzak R. Correlates of avoidance coping in trauma-exposed U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 339: 89-97. PMID: 37437721, DOI: 10.1016/j.jad.2023.07.036.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAvoidance copingTraumatic eventsU.S. military veteransEmotional stabilityNegative affect symptomsEmotional neglectSexual abuseAffect symptomsMilitary veteransAvoidant coping strategiesGreater emotional stabilityPhysical health outcomesPsychosocial risk factorsConsolidated memoryStress disorderCoping strategiesAdverse childhood experiencesStressful experiencesCopingVeterans StudyChildhood experiencesStrong feelingsNetwork analytic approachConscientiousness
News
News
- April 08, 2025
How Does Your Brain Make Decisions? Researchers Develop a Novel Model
- September 09, 2024Source: Yale News
Endocannabinoids Are Associated With Emotional Numbing in PTSD
- May 03, 2024Source: Yale News
Rapid Emotion Transitions May Explain Numbness and Hyperreactivity in PTSD
- January 02, 2024
Duek, Harpaz-Rotem Paper Named '2023 Leading Research Achievement' by BBRF
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