2019
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study
Martinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y. Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study. Neuropsychopharmacology 2019, 44: 1720-1727. PMID: 31026862, PMCID: PMC6785004, DOI: 10.1038/s41386-019-0398-4.Peer-Reviewed Original ResearchConceptsCocaine use disorderStress-induced relapsePositron emission tomographyCocaine bingeKappa-opioid receptor/dynorphin systemKOR selective agonistPositron emission tomography studyKappa-opioid receptorsCold pressor testCocaine self-administration sessionsEmission tomography studiesSelf-administration sessionsStress-induced cocaineEndogenous dynorphinDynorphin systemHealthy controlsPressor testSelective agonistPET scansAnimal studiesKOR bindingReceptor availabilitySignificant associationBrain regionsEmission tomography
2014
Association of In Vivo κ-Opioid Receptor Availability and the Transdiagnostic Dimensional Expression of Trauma-Related Psychopathology
Pietrzak RH, Naganawa M, Huang Y, Corsi-Travali S, Zheng MQ, Stein MB, Henry S, Lim K, Ropchan J, Lin SF, Carson RE, Neumeister A. Association of In Vivo κ-Opioid Receptor Availability and the Transdiagnostic Dimensional Expression of Trauma-Related Psychopathology. JAMA Psychiatry 2014, 71: 1262-1270. PMID: 25229257, DOI: 10.1001/jamapsychiatry.2014.1221.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaBenzamidesCarbon RadioisotopesCase-Control StudiesCross-Sectional StudiesDepressionFemaleFunctional NeuroimagingGyrus CinguliHumansHydrocortisoneMaleNeural PathwaysPhobic DisordersPositron-Emission TomographyPsychiatric Status Rating ScalesPyrrolidinesReceptors, Opioid, kappaStress Disorders, Post-TraumaticVentral StriatumWounds and InjuriesYoung AdultConceptsUrinary cortisol levelsLoss symptomsTrauma-related psychopathologyCortisol levelsNeural circuitsDynorphin/κ-opioid receptor systemΚ-opioid receptor systemHamilton Depression Rating ScaleRating ScaleAdrenal axis systemClinician-Administered PTSD ScalePositron emission tomography studyDepression Rating ScaleHamilton Rating ScaleMechanism-based treatmentsEmission tomography studiesAcademic medical centerPositron emission tomographyKOR systemPreclinical dataTrauma-exposed adultsHigh-resolution positron emission tomographyMedical CenterMAIN OUTCOMEDepressive symptoms