2024
A surgical protocol for establishing spinal cord ischemia with extended lifespan and low complication rates in rats
Yasuda N, Sasaki M, Kocsis J, Kawaharada N, Honmou O. A surgical protocol for establishing spinal cord ischemia with extended lifespan and low complication rates in rats. World Neurosurgery 2024, 188: e349-e356. PMID: 38789035, DOI: 10.1016/j.wneu.2024.05.114.Peer-Reviewed Original ResearchIschemic spinal cord injurySpinal cord ischemiaCord ischemiaComplication rateRat modelTherapeutic strategiesEvaluate new therapeutic strategiesFunctional recoveryMale Sprague-Dawley ratsLow complication rateSprague-Dawley ratsSpecialized surgical equipmentExperimental animal modelsImprove functional recoveryPromote functional recoverySpinal cord injuryCross-clampingSevere neurological disordersAzygos veinSurgical protocolDescending aortaBulldog clampsLumbar levelsSpinal cordIschemic lesions
2020
Intravenous delivery of mesenchymal stem cells protects both white and gray matter in spinal cord ischemia
Yasuda N, Sasaki M, Kataoka-Sasaki Y, Nagahama H, Kocsis JD, Kawaharada N, Honmou O. Intravenous delivery of mesenchymal stem cells protects both white and gray matter in spinal cord ischemia. Brain Research 2020, 1747: 147040. PMID: 32771405, DOI: 10.1016/j.brainres.2020.147040.Peer-Reviewed Original ResearchConceptsIschemic spinal cord injuryIntravenous infusionMesenchymal stem cellsDiffusion tensor imagingGray matterLocomotor functionTherapeutic efficacyHind limb locomotor functionGray matter volume reductionPreservation of microvasculatureSpinal cord ischemiaLeft subclavian arteryPersistent motor deficitsVehicle-treated groupSpinal cord injuryStem cellsBSCB functionISCI ratsAortic surgeryCord ischemiaDevastating complicationNeuronal lossSubclavian arteryMotor deficitsCord injury