2023
Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury
Terada K, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Oka S, Ukai R, Yokoyama T, Iizuka Y, Sakai T, Fukumura S, Tsugawa T, Kocsis J, Honmou O. Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury. Pediatric Research 2023, 94: 1921-1928. PMID: 37422495, DOI: 10.1038/s41390-023-02717-9.Peer-Reviewed Original ResearchConceptsPerinatal brain injuryBrain injuryMesenchymal stem cellsIntravenous infusionVehicle groupBrain volumeTherapeutic efficacyInfused mesenchymal stem cellsLeft common carotid arteryHistological analysisNon-ischemic hemispherePostnatal day 7Common carotid arteryEmbryonic day 18Stem cellsHypoxia-ischemiaMSC infusionPreterm infantsGABAergic cellsNeurological functionSignificant complicationsCortical synapsesFunctional improvementCarotid arteryIntravenous administration
2019
Prevention of neointimal hyperplasia induced by an endovascular stent via intravenous infusion of mesenchymal stem cells.
Nakazaki M, Oka S, Sasaki M, Kataoka-Sasaki Y, Onodera R, Komatsu K, Iihoshi S, Hiroura M, Kawaguchi A, Kocsis JD, Honmou O. Prevention of neointimal hyperplasia induced by an endovascular stent via intravenous infusion of mesenchymal stem cells. Journal Of Neurosurgery 2019, 133: 1773-1785. PMID: 31585431, DOI: 10.3171/2019.7.jns19575.Peer-Reviewed Original ResearchSuperficial cervical arteryCommon carotid arteryMarrow-derived mesenchymal stem cellsIntravenous infusionNeointimal hyperplasiaIschemic eventsInflammatory responseStent restenosisStent strutsMesenchymal stem cellsPorcine modelHuman middle cerebral arteryEndovascular stentsCerebral ischemic eventsPercutaneous transluminal angioplastyMiddle cerebral arteryBare metal stentsBone marrow-derived mesenchymal stem cellsDeployment of stentsStem cellsAngiographic imagesIntravascular ultrasound imagingTransluminal angioplastyCerebral arteryCerebral stroke