2021
Intravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia
Kiyose R, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Magota H, Oka S, Ukai R, Takemura M, Yokoyama T, Kocsis JD, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia. World Neurosurgery 2021, 149: e160-e169. PMID: 33618048, DOI: 10.1016/j.wneu.2021.02.056.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowInfused mesenchymal stem cellsReperfusion therapyPermanent MCAOIntravenous infusionMesenchymal stem cellsTherapeutic efficacyTransient middle cerebral artery occlusion modelMiddle cerebral artery occlusion modelArterial spin labeling magnetic resonance imagingArtery occlusion modelStandard therapeutic strategyTransient MCAO modelCerebral blood flowBehavioral functionsNon-favorable outcomeRat model systemStem cellsMCAO groupStroke inductionAcute strokeCerebral ischemiaNeurologic functionInfusion groupMCAO model
2016
Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats
Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Suzuki J, Tateyama D, Oka S, Namioka T, Namioka A, Onodera R, Mikami T, Wanibuchi M, Kakizawa M, Ishiai S, Kocsis JD, Honmou O. Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats. Physical Therapy 2016, 96: 1791-1798. PMID: 27174259, DOI: 10.2522/ptj.20150504.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionIntravenous infusionDaily rehabilitationMesenchymal stem cellsMSC infusionFunctional outcomePermanent middle cerebral artery occlusionLimb placement testCerebral artery occlusionRat stroke modelRat MCAO modelIntraluminal vascular occlusionMagnetic resonance imagingStem cellsAdult bone marrowArtery occlusionCerebral ischemiaMCAO modelVascular occlusionFunctional improvementLesion volumeTherapy groupTherapeutic effectStroke modelGroup 2
2012
Mesenchymal stem cells: therapeutic outlook for stroke
Honmou O, Onodera R, Sasaki M, Waxman SG, Kocsis JD. Mesenchymal stem cells: therapeutic outlook for stroke. Trends In Molecular Medicine 2012, 18: 292-297. PMID: 22459358, DOI: 10.1016/j.molmed.2012.02.003.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem cellsTransplanted MSCsSpinal cord injuryInitial clinical studiesInitial human studiesBone marrow-derived mesenchymal stem cellsAdult bone marrow-derived mesenchymal stem cellsAdult human bone marrowAxonal sproutingCerebral ischemiaClinical outcomesNeuroprotective effectsCord injuryHuman bone marrowClinical studiesTherapeutic effectStroke modelAnimal modelsHuman studiesBone marrowMesenchymal stem cellsIntravenous deliveryTherapeutic outlookMSC deliveryStroke
2009
A Rat Middle Cerebral Artery Occlusion Model and Intravenous Cellular Delivery
Sasaki M, Honmou O, Kocsis JD. A Rat Middle Cerebral Artery Occlusion Model and Intravenous Cellular Delivery. Methods In Molecular Biology 2009, 549: 187-195. PMID: 19378204, DOI: 10.1007/978-1-60327-931-4_13.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusion modelArtery occlusion modelCerebral ischemiaIntraluminal sutureOcclusion modelRat middle cerebral artery occlusion modelInternal carotid arteryInterventional therapeutic approachesMagnetic resonance imagingUseful experimental modelNormal pathophysiologyInfarction volumeStroke therapyPermanent occlusionCarotid arteryReversible occlusionTherapeutic approachesIntravenous deliveryResonance imagingSuture insertionExperimental modelIschemiaAnimal weightPathophysiologySuture