2022
Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients
Coyne DW, Singh AK, Lopes RD, Bailey CK, DiMino TL, Huang C, Connaire J, Rastogi A, Kim SG, Orias M, Shah S, Patel V, Cobitz AR, Wanner C. Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1325-1336. PMID: 35918106, PMCID: PMC9625096, DOI: 10.2215/cjn.00550122.Peer-Reviewed Original ResearchConceptsErythropoiesis-stimulating agentsTimes weekly dosingTRIAL REGISTRY NAMESecondary end pointsTreatment of anemiaEpoetin groupDaprodustat groupEnd pointWeekly dosingREGISTRY NAMEHemoglobin valuesMean changeHypoxia-inducible factor prolyl hydroxylase inhibitorCLINICAL TRIAL REGISTRY NAMEPrincipal secondary end pointTreatment-emergent adverse eventsIntravenous iron doseIntravenous iron usePrimary end pointChronic kidney diseaseMean hemoglobin valuesEvaluation periodProlyl hydroxylase inhibitorBaseline hemoglobinPrevalent hemodialysis
2011
Preemptive Kidney Transplantation: Experience in Two Centers
Rigo DH, Ziraldo L, Di Monte L, Jimenez MP, Giotto AP, Gutierrez L, Rodriguez I, Orias M, Novoa PA. Preemptive Kidney Transplantation: Experience in Two Centers. Transplantation Proceedings 2011, 43: 3355-3358. PMID: 22099795, DOI: 10.1016/j.transproceed.2011.09.083.Peer-Reviewed Original ResearchConceptsPreemptive kidney transplantEnd-stage renal diseaseDelayed graft functionSubclinical rejectionKidney transplantDeceased donorsInterstitial fibrosis/tubular atrophyDeceased donor groupChronic allograft nephropathyPreemptive kidney transplantationRenal replacement therapyDonor kidney transplantsLong-term dialysisQuality of lifeAllograft nephropathyGraft functionKidney transplantationPreemptive transplantationMonths posttransplantationSerum creatinineTransplantation centersRenal diseaseTubular atrophyCalcineurin inhibitorsPoor outcome