2022
Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension
Stergiou G, Brunström M, MacDonald T, Kyriakoulis KG, Bursztyn M, Khan N, Bakris G, Kollias A, Menti A, Muntner P, Orias M, Poulter N, Shimbo D, Williams B, Adeoye AM, Damasceno A, Korostovtseva L, Li Y, Muxfeldt E, Zhang Y, Mancia G, Kreutz R, Tomaszewski M. Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension. Journal Of Hypertension 2022, 40: 1847-1858. PMID: 35983870, DOI: 10.1097/hjh.0000000000003240.Peer-Reviewed Original ResearchMeSH KeywordsAntihypertensive AgentsBlood PressureBlood Pressure Monitoring, AmbulatoryCircadian RhythmHumansHypertensionProspective StudiesConceptsAntihypertensive drugsAntihypertensive medicationsBedtime dosingOutcome trialsDrug dosingClinical practiceEfficient medical interventionsHypertension position paperMorning BP surgeNight-time hypertensionAntihypertensive drug therapyAntihypertensive drug treatmentSingle morning doseBlood pressure profileEffective treatment strategiesWorld Hypertension LeagueInternational SocietyAntihypertensive treatmentBedtime administrationBP controlBP surgeMorning doseMorning dosingCardiovascular eventsAdverse prognosis
2012
Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin
Marquez D, Ramonda C, Lauxmann JE, Romero CA, Vukelic VL, Martinatto C, Barrón B, Novoa PA, Peixoto AJ, Orías M. Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. Brazilian Journal Of Nephrology 2012, 34: 148-152. PMID: 22850916, DOI: 10.1590/s0101-28002012000200007.Peer-Reviewed Original ResearchConceptsUremic pruritusPruritus scoreOne-week washout periodOne-week runAlternate regimenChronic hemodialysisPrimary endpointExcessive sedationVAS scoresDialysis patientsHemodialysis patientsWashout periodMarginal efficacyClinical trialsPruritusSignificant reliefEffective treatmentNineteen subjectsSide effectsGabapentinPatientsMore weeksDesloratadineStatistical significanceTreatment