Chirag Parikh, MD, PhD, FACP
Professor AdjunctCards
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Professor Adjunct
Biography
Dr. Parikh is an Adjunct Professor of Medicine, section of Nephrology. Currently at Johns Hopkins University, Dr. Parikh continues his research projects and collaborations with F. Perry Wilson, MD, MSCE, the Interim Director of the Program of Applied Translational Research (PATR) and with other faculty and collaborators within PATR.
Dr. Parikh received his MD from Mumbai, India in 1996. His post-graduate training involves Residency in Internal Medicine at Nassau University and SUNY in Stony Brook, NY, and Fellowship in Nephrology and Hypertension at the University of Colorado Health Sciences Center in Denver, CO. He also completed a PhD in Clinical Investigation and Translational Research at University of Colorado Health Sciences Center, Denver, CO in 2003. He is board certified in both Internal Medicine and Nephrology. He has received several awards, including the National Junior Physician Investigator Award from the American Federation of Medical Research and the Outstanding Investigator Award from the Society of Clinical Investigation.
Dr. Parikh conducts an active patient-oriented research program investigating the translational and epidemiological aspects of acute kidney injury (AKI) and other kidney related disorders. His major research interest is developing novel biomarkers of AKI. He is the Principal Investigator of the NIH sponsored TRIBE-AKI consortium that is conducting large studies for validating novel kidney injury biomarkers in setting of cardiac surgery, kidney transplantation, diabetic kidney disease and hepatorenal syndrome. He has authored more than 250 peer-reviewed papers, 50 book chapters and reviews, and he has given more than 50 invited lectures at scientific meetings and academic institutions around the world.
Appointments
Departments & Organizations
Education & Training
- PhD
- University of Colorado at Denver (2003)
- MD
- Seth G.S. Medical College (1996)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0001-9051-7385- View Lab Website
Program of Applied Translation Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Dennis G Moledina, MD, PhD, FASN
Harlan Krumholz, MD, SM
Justin Belcher, MD, PhD, FASN
F. Perry Wilson, MD, MSCE
Gilbert Moeckel, MD, PhD, FASN
Guadalupe Garcia-Tsao, MD, FRCP
Acute Kidney Injury
Kidney Diseases
Publications
2024
Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis
Wen Y, Mansour S, Srialluri N, Hu D, Philbrook H, Hall I, Doshi M, Mohan S, Reese P, Parikh C. Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis. JAMA 2024, 332: 215-225. PMID: 38780515, PMCID: PMC11117155, DOI: 10.1001/jama.2024.8469.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDeath-censored graft failureKidney transplant recipientsGraft failureDeceased kidney donorsKidney transplantationTransplant recipientsGraft functionDeceased donorsFollow-upHigher risk of delayed graft functionIncidence of delayed graft functionOutcomes of transplant recipientsRisk of delayed graft functionMedian follow-upKidney donorsDelayed graft functionUS organ procurement organizationsKidney transplant outcomesRetrospective cohort studyRecipients of kidneysKidney donationAcute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function
Bhatraju P, Zelnick L, Stanaway I, Ikizler T, Menez S, Chinchilli V, Coca S, Kaufman J, Kimmel P, Parikh C, Go A, Siew E, Wurfel M, Himmelfarb J. Acute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function. Clinical Journal Of The American Society Of Nephrology 2024, 19: 829-836. PMID: 38728094, PMCID: PMC11254015, DOI: 10.2215/cjn.0000000000000473.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsLong-term cognitive impairmentRisk of long-term cognitive impairmentCognitive impairmentCognitive functionCognitive declineSoluble TNF receptor-1 concentrationsAssociated with poorer cognitive functionModified Mini-Mental Status ExaminationLong-term cognitive functionPoorer cognitive functionMini-Mental Status ExaminationLong-term cognitive declineSystemic inflammationCognitive testsCognitive dysfunctionSerial evaluationMediation analysisPersistent systemic inflammationSystemic inflammatory biomarkersAcute kidney injuryBaseline kidney functionComplication of CKDAssociated with long-term cognitive declineEpisode of AKITNF receptor 1Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase–Associated Lipocalin for Acute Kidney Injury in Cirrhosis
Puthumana J, Lugon N, Xu Y, Deng Y, Mistry P, Parikh C, Consortium T, Angeli P, Belcher J, Gambino C, Salaheldin M, Treepraertsuk S. Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase–Associated Lipocalin for Acute Kidney Injury in Cirrhosis. Kidney International Reports 2024, 9: 2278-2281. PMID: 39081737, PMCID: PMC11284356, DOI: 10.1016/j.ekir.2024.04.050.Peer-Reviewed Original ResearchAltmetricThe development of lateral flow devices for urinary biomarkers to assess kidney health
D Souza S, Obeid W, Hernandez J, Hu D, Wen Y, Moledina D, Albert A, Gregg A, Wheeler A, Philbrook H, Parikh C. The development of lateral flow devices for urinary biomarkers to assess kidney health. Scientific Reports 2024, 14: 8516. PMID: 38609491, PMCID: PMC11014899, DOI: 10.1038/s41598-024-59104-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLateral flow deviceInterleukin-9Development of lateral flow devicesUrinary biomarkersDetection antibody concentrationSerum creatinine levelsKidney healthPaired antibodiesEnzyme Linked Immunosorbent AssayCreatinine levelsKidney injuryKidney functionOsteopontinImmunosorbent assayAntibody concentrationsMeasured biomarkersKidneyReal-time changesBiomarkersAre biomarkers in acute kidney injury ready for prime time? The time is right for a second look
Parikh C, Coca S. Are biomarkers in acute kidney injury ready for prime time? The time is right for a second look. Kidney International 2024, 105: 675-678. PMID: 38519236, DOI: 10.1016/j.kint.2024.01.018.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsThe authors reply
Hu D, Menez S, Thiessen-Philbrook H, Parikh C. The authors reply. Kidney International 2024, 105: 391. PMID: 38245219, DOI: 10.1016/j.kint.2023.10.026.Peer-Reviewed Original ResearchPHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS.
Parikh C, Hernandez J. PHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS. Transactions Of The American Clinical And Climatological Association 2024, 134: 37-46. PMID: 39135588, PMCID: PMC11316880.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAcute kidney injuryChronic kidney diseaseKidney injuryEpisodes of acute kidney injuryAssociated with long-term riskLong-term risk of readmissionLong-term sequelaeRepair biomarkersRisk of readmissionSubclinical inflammationPreclinical studiesUrine biomarkersResearch biopsiesDeceased donor kidneysClinical trialsKidney diseaseBlood pressureMedical managementDonor kidneysPragmatic clinical trialsKidney tissueTherapeutic developmentOrgan allocationPrecision medicineKidney
2023
Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatients
2016
Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study
Greenberg JH, Zappitelli M, Devarajan P, Thiessen-Philbrook HR, Krawczeski C, Li S, Garg AX, Coca S, Parikh CR. Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study. JAMA Pediatrics 2016, 170: 1071-1078. PMID: 27618162, PMCID: PMC5476457, DOI: 10.1001/jamapediatrics.2016.1532.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLong-term kidney outcomesAcute kidney injuryChronic kidney diseasePediatric cardiac surgeryPerioperative acute kidney injuryPostoperative acute kidney injuryCardiac surgeryKidney diseaseKidney outcomesKidney injuryHigh short-term morbidityProspective multicenter cohort studySerum creatinine riseMulticenter cohort studyShort-term morbidityAge 1 monthOutcomes 5 yearsRenal outcomesPreoperative baselineCohort studyPediatric centersCardiopulmonary bypassCreatinine risePerson followPerson visitsA Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury
Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. American Journal Of Respiratory And Critical Care Medicine 2016, 195: 482-490. PMID: 27576016, PMCID: PMC5378420, DOI: 10.1164/rccm.201603-0518oc.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAcute Kidney InjuryAdultAgedApolipoprotein L1ApolipoproteinsBiomarkersCardiac Surgical ProceduresCase-Control StudiesCritical IllnessFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansIntensive Care UnitsInterferon Regulatory Factor-2Lipoproteins, HDLMaleMiddle AgedPolymorphism, Single NucleotidePostoperative ComplicationsRisk FactorsStatistics, NonparametricT-Box Domain ProteinsConceptsAcute kidney injuryGenome-wide association studiesSingle nucleotide polymorphismsKidney injuryGenetic lociAssociation studiesExploratory genome-wide association studyAcute kidney injury casesHospital acute kidney injuryCommon genetic variantsIndependent lociGene TBX1Chromosome 4Novel pathwayCritical illnessCardiac surgerySevere complicationsLociPatient populationTherapeutic advancesGenetic variantsGenotype imputationInjury casesExpedite recoveryInjury
Academic Achievements & Community Involvement
honor Jeff Gray Memorial "Translating to Management in AKI"
National AwardAKI and CRRT 2017 22nd International ConferenceDetails03/09/2017United Stateshonor Dr. MD Motashaw Oration and Award for Research Accomplishment
International AwardSeth G.S. Medical College and KEM HospitalDetails04/24/2013India
News
News
- July 05, 2023
Researchers Find New Way to Diagnose Drug-Induced Kidney Inflammation
- November 13, 2018
MD Candidate Jeremy Puthumana Named to Forbes "30 Under 30" List
- February 20, 2018
Medical faculty elected to the American Society for Clinical Investigation
- December 25, 2017
Parikh receives recognition for nephrology work