Antidepressant actions of the exercise-regulated gene VGF
Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS. Antidepressant actions of the exercise-regulated gene VGF. Nature Medicine 2007, 13: 1476-1482. PMID: 18059283, DOI: 10.1038/nm1669.Peer-Reviewed Original ResearchConceptsAntidepressant actionAntidepressant responseRobust antidepressant responseAction of antidepressantsAntidepressant drug developmentVGF nerve growth factorVGF-derived peptidesPotential therapeutic targetDepressed human subjectsNerve growth factorGrowth factor pathwaysNeurotrophic factorMouse hippocampusTherapeutic targetSynaptic plasticityBrain regionsFactor pathwayGrowth factorTarget genesCustom microarrayHealth benefitsPathway analysisVGFHuman subjectsDrug development