Karthik Murugiah, MBBS, MHS
Assistant Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
2025
Invasive Pulmonary Angiogram Performance and Interpretation in the Diagnosis of Pulmonary Thromboembolic Disease
Bae J, Murugiah K. Invasive Pulmonary Angiogram Performance and Interpretation in the Diagnosis of Pulmonary Thromboembolic Disease. Cardiac Electrophysiology Clinics 2025, 17: 287-295. PMID: 40835299, DOI: 10.1016/j.ccep.2024.12.006.Peer-Reviewed Original ResearchConceptsInvasive pulmonary angiographyPulmonary thromboembolic diseasePulmonary angiographyThromboembolic diseaseGold standard diagnostic testSelective pulmonary angiographyOptimal patient positionStandard diagnostic testNoninvasive imaging modalityPulmonary vascular anatomyPharmacomechanical therapyAngiographic positionAngiographic patternPatient positioningVascular accessAngiographyVascular anatomyImaging modalitiesDiagnostic testsCatheter selectionDiseaseArterial conditionsTherapyCatheterDiagnosisTwists and Turns on the Road to Angina Relief
Murugiah K, Shun-Shin M, Al-Lamee R. Twists and Turns on the Road to Angina Relief. Journal Of The American College Of Cardiology 2025, 86: 794-796. PMID: 40930616, DOI: 10.1016/j.jacc.2025.07.016.Peer-Reviewed Original ResearchCharacterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study
AL Mouslmani M, Sawano M, Arun A, Wu Y, Shah R, Kaleem S, Zhou T, Murugiah K, Lu Y, Herrin J, Bishop P, Taub P, Peixoto A, Bhattacharjee B, Iwasaki A, Krumholz H. Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study. JACC Advances 2025, 4: 101873. PMID: 40883051, PMCID: PMC12399260, DOI: 10.1016/j.jacadv.2025.101873.Peer-Reviewed Original ResearchSelf-reported diagnosisPostural orthostatic tachycardia syndromeHealth statusSelf-reported long COVIDOrthostatic tachycardia syndromeHealth status of peopleEuroQol visual analog scaleDiagnosis of postural orthostatic tachycardia syndromeOnline observational studyExperiences of peopleStatus of peoplePostacute COVID-19 syndromeChest painVisual analog scaleHigher RatesExcessive fatigueHealth burdenMyalgic encephalomyelitis/chronic fatigue syndromeSocial isolationInternal tremorExercise intoleranceObservational studyFinancial difficultiesAnalog scaleSuicidal thoughtsDevelopment and Validation of an Administrative Claims Measure of Emergency Medical Services (EMS) Triage Quality for Mobile Integrated Health Interventions
Voll N, Gettel C, Li S, Qin L, Li Y, Attanasio S, Epshtein I, Nichols M, Lilly A, Quinton J, Bernheim S, Stiles H, Murugiah K, Mann N, Venkatesh A. Development and Validation of an Administrative Claims Measure of Emergency Medical Services (EMS) Triage Quality for Mobile Integrated Health Interventions. Prehospital Emergency Care 2025, ahead-of-print: 1-8. PMID: 40689629, DOI: 10.1080/10903127.2025.2535574.Peer-Reviewed Original ResearchAmbulance organizationsEmergency departmentPrehospital carePatient safetyMeasure scoresConstruct validityFace validityIntegrative health interventionsEffective prehospital carePatient-level variablesQuality measuresGround ambulance servicesPrehospital measuresClaims measuresEmergency careHealth interventionsAmbulance servicesUrgent careED visitsEmergency triageMeasure cohortCareCase thresholdsMeasured outcomesAmbulanceRelationship between industry payments to physicians and prescription patterns for PCSK9is, ARNis and DOACs: A report from the NCDR PINNACLE registry
Annapureddy A, Murugiah K, Zheng L, Minges K, Grandhi G, Ross J, Ahmad T, Rodwin B, Dhruva S, Girotra S, Dayoub E, Curtis J, Desai N. Relationship between industry payments to physicians and prescription patterns for PCSK9is, ARNis and DOACs: A report from the NCDR PINNACLE registry. American Heart Journal 2025, 291: 26-36. PMID: 40714034, DOI: 10.1016/j.ahj.2025.07.015.Peer-Reviewed Original ResearchAngiotensin receptor-neprilysin inhibitorDirect oral anticoagulantsProprotein convertase subtilisin/kexin type 9Nonvalvular atrial fibrillationProprotein convertase subtilisin/kexin type 9 inhibitorsAtherosclerotic cardiovascular diseasePINNACLE RegistryDirect oral anticoagulant prescribingNonvalvular atrial fibrillation patientsReduced ejection fractionProportion of patientsAtherosclerotic cardiovascular disease patientsNo significant associationAssociated with prescribingPCSK inhibitorsHFrEF patientsOral anticoagulantsIndustry paymentsEjection fractionHFrEF cohortPCSK9 inhibitorsPatient cohortAtrial fibrillationPrescription patternsHeart failureHPR108 Trends in the Prescribing and Dispensing of GLP-1 Anti-Obesity Medications Among U.S. Adults with Cardiovascular Disease and Overweight or Obesity, 2021-2024
Do D, Murugiah K, Sawano M, Rodriguez P, Cartwright B, Curtis L, Stucky N. HPR108 Trends in the Prescribing and Dispensing of GLP-1 Anti-Obesity Medications Among U.S. Adults with Cardiovascular Disease and Overweight or Obesity, 2021-2024. Value In Health 2025, 28: s212. DOI: 10.1016/j.jval.2025.04.832.Peer-Reviewed Original ResearchMechanical Circulatory Support in Acute Myocardial Infarction–Cardiogenic Shock 2025 Acute Coronary Syndrome Guideline in Context
Murugiah K, McDonagh T, Cohen D, Dhruva S. Mechanical Circulatory Support in Acute Myocardial Infarction–Cardiogenic Shock 2025 Acute Coronary Syndrome Guideline in Context. Journal Of The American College Of Cardiology 2025, 85: 2103-2106. PMID: 40467139, DOI: 10.1016/j.jacc.2025.04.025.Peer-Reviewed Original ResearchHealthcare Expenditure on Atrial Fibrillation in the United States The Medical Expenditure Panel Survey 2016 to 2021
See C, Grubman S, Shah N, Hu J, Nanna M, Freeman J, Murugiah K. Healthcare Expenditure on Atrial Fibrillation in the United States The Medical Expenditure Panel Survey 2016 to 2021. JACC Advances 2025, 4: 101716. PMID: 40286372, PMCID: PMC12103078, DOI: 10.1016/j.jacadv.2025.101716.Peer-Reviewed Original ResearchMedical Expenditure Panel SurveyHealthcare expendituresInternational Classification of Disease-10 codesNationally representative assessmentTotal healthcare expendituresPoor income levelsPanel SurveyHigher expendituresIncreased healthcare expendituresAssociated with higher expendituresChronic obstructive pulmonary diseaseModified Charlson Comorbidity IndexObstructive pulmonary diseaseInpatient visitsInternational ClassificationType 2 diabetes mellitusSurvey yearCharlson Comorbidity IndexAtherosclerotic cardiovascular diseaseUnited StatesIdentifying individualsCardiovascular diseaseGamma regression modelRegression modelsRepresentative assessmentRecent Trends in Aspirin Use for Cardiovascular Disease Prevention in the United States, 2015 to 2023
Murugiah K, See C, Huang C. Recent Trends in Aspirin Use for Cardiovascular Disease Prevention in the United States, 2015 to 2023. JACC Advances 2025, 4: 101699. PMID: 40243986, PMCID: PMC12277617, DOI: 10.1016/j.jacadv.2025.101699.Peer-Reviewed Original ResearchCHARACTERIZATION OF POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME IN LONG COVID: A CROSS-SECTIONAL STUDY AND A MACHINE LEARNING MODEL
AL Mouslmani M, Sawano M, Arun A, Wu Y, Shah R, Kaleem S, Zhou T, Murugiah K, Lu Y, Herrin J, Taub P, Peixoto A, Krumholz H. CHARACTERIZATION OF POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME IN LONG COVID: A CROSS-SECTIONAL STUDY AND A MACHINE LEARNING MODEL. Journal Of The American College Of Cardiology 2025, 85: 2720. DOI: 10.1016/s0735-1097(25)03204-8.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Teaching & Mentoring
Mentoring
Tom Shin
Postdoc2023 - PresentClaudia See
Medical student2022 - 2024Ju-Young Bae
Postdoc2021 - 2024
Clinical Care
Overview
Karthik Murugiah, MBBS (a medical degree awarded in several countries outside of the U.S.), is an interventional cardiologist and specializes in treating coronary artery disease, heart attacks, heart failure, pulmonary hypertension, and other conditions.
Dr. Murugiah says he was drawn to cardiology because of its promise and potential. “Cardiology is an extremely fast-paced specialty with a large and rigorous evidence base and a wide gamut of treatments,” he says. “This makes being a cardiologist especially gratifying. I love talking to patients, hearing their stories, helping them understand their illness and make decisions about their health. We can deliver cutting-edge treatments for cardiac conditions to every patient in line with the latest medical evidence.”
The best part of his job, he says, is helping patients recover from life-threatening cardiac conditions and helping them manage chronic cardiac problems, so that they can enjoy their lives to the fullest extent possible.
Recognizing that patients often feel anxious about medical procedures, Dr. Murugiah says he makes sure they have a clear understanding of the treatment and what to expect during and after it. “I emphasize to patients that we will always have their best interest in mind with every decision we take or treatments we recommend,” he says. “I also tell patients undergoing procedures to lean on the experience of my catheterization lab team and I.”
An active researcher, Dr. Murugiah focuses on harnessing electronic health records and other large datasets to develop prediction models and evaluate changes in health and health care delivery to answer important questions in cardiology care in the U.S. and globally.
Clinical Specialties
Interventional Cardiology
Fact Sheets
Heart Attack (Myocardial Infarction)
Learn More on Yale MedicinePulmonary Edema
Learn More on Yale MedicineCoronary Artery Disease (CAD)
Learn More on Yale MedicineBlood Clots in Veins, Heart and Lungs
Learn More on Yale Medicine
Board Certifications
Interventional Cardiology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2019
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2018
Yale Medicine News
News
News
- July 02, 2024
Yale Faculty Members Named to JACC Editorial Board
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- February 01, 2023
2023 American College of Cardiology late-breaking clinical trials and abstracts from Yale
- January 18, 2023
Inpatient blood draws are often performed during sleep hours, Yale study finds
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