Zebrafish as a Model System for the Study of Severe CaV2.1 (α1A) Channelopathies
Tyagi S, Ribera AB, Bannister RA. Zebrafish as a Model System for the Study of Severe CaV2.1 (α1A) Channelopathies. Frontiers In Molecular Neuroscience 2020, 12: 329. PMID: 32116539, PMCID: PMC7018710, DOI: 10.3389/fnmol.2019.00329.Peer-Reviewed Original ResearchFamilial hemiplegic migraine type 1Heterologous expressionSubunit of CaNeuromuscular junctionResultant phenotypeBehavioral defectsChannel functionMissense mutationsMechanistic understandingEpisodic ataxia type 2ZebrafishMutationsNeurotransmitter releaseModel systemCentral synapsesMore severe disordersQ-type CaChannelopathiesSubunitsPhenotypeNovoExpressionWide spectrumDevelopmental delayCa