2023
Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8
Baker C, Tyagi S, Higerd-Rusli G, Liu S, Zhao P, Dib-Hajj F, Waxman S, Dib-Hajj S. Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8. Frontiers In Molecular Neuroscience 2023, 16: 1130123. PMID: 36860665, PMCID: PMC9970094, DOI: 10.3389/fnmol.2023.1130123.Peer-Reviewed Original ResearchChemotherapy-induced peripheral neuropathyDorsal root gangliaPTX treatmentDRG axonsEffect of paclitaxelVoltage-gated sodium channel NaPain syndromePeripheral neuropathyDRG neuronsSodium channel NaRoot gangliaCell cycle arrestNeuronal somataSensory neuronsSide effectsTherapeutic targetingTumor growthPaclitaxel effectAntineoplastic agentsAxonal localizationPaclitaxelNumber of NaAxonal compartmentAxonsChannel Na
2013
Sodium Channels Contribute to Degeneration of Dorsal Root Ganglion Neurites Induced by Mitochondrial Dysfunction in an In Vitro Model of Axonal Injury
Persson AK, Kim I, Zhao P, Estacion M, Black JA, Waxman SG. Sodium Channels Contribute to Degeneration of Dorsal Root Ganglion Neurites Induced by Mitochondrial Dysfunction in an In Vitro Model of Axonal Injury. Journal Of Neuroscience 2013, 33: 19250-19261. PMID: 24305821, PMCID: PMC6618782, DOI: 10.1523/jneurosci.2148-13.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsAxotomyCell DeathCells, CulturedGanglia, SpinalHumansHydrogen PeroxideImmunohistochemistryMiceMice, TransgenicMicrotubulesMitochondrial DiseasesNerve DegenerationNeuritesOxidantsRotenoneSodium Channel BlockersSodium ChannelsSodium-Calcium ExchangerSodium-Potassium-Exchanging ATPaseTetrodotoxinThioureaUncoupling AgentsConceptsAxonal degenerationNeurite degenerationSodium channelsKB-R7943Mouse peripheral sensory neuronsRotenone-induced mitochondrial dysfunctionOxidative stressMitochondrial dysfunctionPeripheral sensory neuronsDorsal root gangliaPeripheral nervous systemDegeneration of neuritesMitochondrial functionVoltage-gated sodium channelsMultiple neurodegenerative disordersSodium-calcium exchangerImpaired mitochondrial functionInjurious cascadeAxonal injuryActivity blockadeRoot gangliaAxonal neuropathySensory neuronsNCX activityDysfunctional intracellular
2012
Nav1.7-related small fiber neuropathy
Han C, Hoeijmakers JG, Ahn H, Zhao P, Shah P, Lauria G, Gerrits MM, te Morsche R, Dib-Hajj SD, Drenth JP, Faber CG, Merkies IS, Waxman SG. Nav1.7-related small fiber neuropathy. Neurology 2012, 78: 1635-1643. PMID: 22539570, DOI: 10.1212/wnl.0b013e3182574f12.Peer-Reviewed Original ResearchConceptsSmall fiber neuropathyDorsal root gangliaDRG neuronsIdiopathic small fiber neuropathySmall-diameter peripheral axonsDRG neuron hyperexcitabilityIdentifiable underlying causeNerve conduction studiesQuantitative sensory testingSympathetic ganglion neuronsSFN symptomsNeuron hyperexcitabilityConduction studiesGanglion neuronsRoot gangliaSkin biopsiesDifferential diagnosisPeripheral axonsSensory testingVoltage-clamp analysisApparent causePatientsNoninactivating componentUnderlying causeSuprathreshold stimuli
2011
Nav1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory Neurons
Ahn HS, Black JA, Zhao P, Tyrrell L, Waxman SG, Dib-Hajj SD. Nav1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory Neurons. Molecular Pain 2011, 7: 1744-8069-7-32. PMID: 21569247, PMCID: PMC3101130, DOI: 10.1186/1744-8069-7-32.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGanglia, SpinalGene Expression RegulationIn Situ HybridizationIon Channel GatingMaleMiceMice, Inbred C57BLNAV1.6 Voltage-Gated Sodium ChannelNAV1.7 Voltage-Gated Sodium ChannelOlfactory MucosaOlfactory Receptor NeuronsPolymerase Chain ReactionRatsRats, Sprague-DawleyRNA, MessengerSodium ChannelsConceptsDorsal root gangliaOlfactory sensory neuronsSodium channelsSensory neuronsNervous systemSodium channel transcriptsVoltage-gated sodium channel Nav1.7Peripheral nervous systemCentral nervous systemCompound heterozygous lossSodium channel Nav1.7Channel transcriptsPeripheral olfactory sensory neuronsCongenital insensitivityRoot gangliaSympathetic neuronsOSN axonsOlfactory bulbPostsynaptic cellOlfactory epitheliumChannel Nav1.7Nav1.7Nav1.6 channelsNull miceAnosmia