2001
Acquired channelopathies in nerve injury and MS
Waxman S. Acquired channelopathies in nerve injury and MS. Neurology 2001, 56: 1621-1627. PMID: 11428390, DOI: 10.1212/wnl.56.12.1621.Peer-Reviewed Original ResearchConceptsNerve injurySodium channelsSensory neuron-specific sodium channelsSodium channel geneChannel genesPeripheral nerve injurySpinal sensory neuronsPathophysiology of MSSubtype-specific drugsDistinct sodium channelsVoltage-gated sodium channelsSpecific sodium channelsAxonal transectionGenetic channelopathyPrototype disorderSensory neuronsPurkinje cellsTherapeutic opportunitiesChannelopathiesAbnormal expressionInjuryMolecular changesHyperexcitabilityCellsTransection
1996
Mechanisms of Paresthesiae, Dysesthesiae, and Hyperesthesiae: Role of Na+ Channel Heterogeneity
Rizzo M, Kocsis J, Waxman S. Mechanisms of Paresthesiae, Dysesthesiae, and Hyperesthesiae: Role of Na+ Channel Heterogeneity. European Neurology 1996, 36: 3-12. PMID: 8719643, DOI: 10.1159/000117192.Peer-Reviewed Original ResearchConceptsAxonal injuryCutaneous afferentsDorsal root ganglion neuronsAction potential activityNormal sensory functionEctopic impulsesDRG neuronsClinical syndromeGanglion neuronsSensory functionMembrane excitabilityInjuryNerve impulsesDysesthesiaeChannel physiologyMolecular changesParesthesiaeAfferentsPreliminary evidenceNeuronsEctopicMolecular mechanismsSensory anatomyPotential activityPopulation
1986
Different effects of 4-aminopyridine on sensory and motor fibers: pathogenesis of paresthesias.
Kocsis J, Bowe C, Waxman S. Different effects of 4-aminopyridine on sensory and motor fibers: pathogenesis of paresthesias. Neurology 1986, 36: 117-20. PMID: 3001584, DOI: 10.1212/wnl.36.1.117.Peer-Reviewed Original Research
1982
Diabetic Radiculoneuropathy: Clinical patterns of sensory loss and distal paresthesias
Waxman S. Diabetic Radiculoneuropathy: Clinical patterns of sensory loss and distal paresthesias. Acta Diabetologica 1982, 19: 199-207. PMID: 7148327, DOI: 10.1007/bf02624679.Peer-Reviewed Original Research
1976
Probability of conduction deficit as related to fiber length in random-distribution models of peripheral neuropathies
Waxman S, Brill M, Geschwind N, Sabin T, Lettvin J. Probability of conduction deficit as related to fiber length in random-distribution models of peripheral neuropathies. Journal Of The Neurological Sciences 1976, 29: 39-53. PMID: 181541, DOI: 10.1016/0022-510x(76)90079-4.Peer-Reviewed Original ResearchConceptsPeripheral neuropathyAxonal dysfunctionSensory deficitsDistal sensory deficitsNormal sensory conductionRapid clinical progressionConduction deficitsSensory conductionClinical progressionNerve fibersConduction blockNeuropathyDysfunctionMarked reductionProximodistal gradientPossible correlatesDeficitsSmall increaseParesthesiaeAbnormalitiesProgression