2007
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons
Rush AM, Cummins TR, Waxman SG. Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. The Journal Of Physiology 2007, 579: 1-14. PMID: 17158175, PMCID: PMC2075388, DOI: 10.1113/jphysiol.2006.121483.Peer-Reviewed Original ResearchConceptsSodium channel isoformsDorsal root ganglion neuronsChannel isoformsDRG neuronsGanglion neuronsSpecific sodium channel isoformsMultiple sodium channelsSodium channelsPattern of expressionModulatory moleculesDisease insultsModulation of channelsPlasticity of expressionNeuronsDifferent subclassesExcitabilityDistinct biophysical characteristicsIsoformsExpressionBody of literatureInsultImportant roleResponse
2002
HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons
White BH, Cummins TR, Wolf DH, Waxman SG, Russell DS, Kaczmarek LK. HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons. Journal Of Neurophysiology 2002, 87: 2149-2157. PMID: 11929932, DOI: 10.1152/jn.00498.2001.Peer-Reviewed Original ResearchConceptsSodium currentAnti-HSV antibodiesAverage spike frequencyWild-type HSV-1Helper virusViral-based strategiesDays of transductionCultured neuronsHSV-1Spike frequencyGene deliveryNeuronsMammalian neuronsAmplicon systemSimilar suppressionHSV-1 genesVirusTherapeutic purposesViral proteinsAmplicon preparationsCellsCoinfectionSuppressionPreparation resultsTiters
2000
The neuron as a dynamic electrogenic machine: modulation of sodiumchannel expression as a basis for functional plasticity in neurons
Waxman S. The neuron as a dynamic electrogenic machine: modulation of sodiumchannel expression as a basis for functional plasticity in neurons. Philosophical Transactions Of The Royal Society B Biological Sciences 2000, 355: 199-213. PMID: 10724456, PMCID: PMC1692729, DOI: 10.1098/rstb.2000.0559.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsElectric ConductivityGene ExpressionNeuronal PlasticityNeuronsSodium ChannelsConceptsSodium channelsMammalian nervous systemSodium channel geneNervous systemDozen genesDistinct sodium channelsVoltage-gated sodium channelsGenesElectrogenic machineryNormal nervous systemSodium channel expressionFunctional plasticityMembrane of neuronsAction potential activityTranscriptionPathological insultsPhysiological inputsMost neuronsCrucial roleExpressionNeuronsFunctional propertiesElectroresponsive propertiesPotential activityMachinery
1996
Action potential-like responses in B 104 cells with low Na+ channel densities
Gu X, Waxman S. Action potential-like responses in B 104 cells with low Na+ channel densities. Brain Research 1996, 735: 50-58. PMID: 8905169, DOI: 10.1016/0006-8993(96)00604-x.Peer-Reviewed Original ResearchConceptsAction potential-like responsesB104 cellsWhole-cell patch-clamp methodB104 neuroblastoma cellsPA/pFCurrent-clamp modeSteady-state inactivationAction potential generationPatch-clamp methodMicroM TTXNeuroblastoma cellsPrepulse potentialPotential generationResponse amplitudeCellsResponseStimuli
1983
Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum
Preston R, Waxman S, Kocsis J. Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum. Experimental Neurology 1983, 79: 808-820. PMID: 6825765, DOI: 10.1016/0014-4886(83)90044-4.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAction PotentialsAminopyridinesAnimalsAxonsCorpus CallosumElectric ConductivityFemaleRatsRats, Inbred StrainsConceptsRat corpus callosumCallosal fibersCerebral axonsNerve fibersCorpus callosumMammalian peripheral nerve fibersNegative waveVoltage-dependent potassium currentsSecond negative waveNon-myelinated nerve fibresPeripheral nerve fibersField potentialsShort-latency wavesFirst negative waveCallosal stimulationPotassium blockersPotassium currentAction potentialsPeripheral fibersCallosumRecording electrodesMembrane repolarizationAxonsFunctional organizationComparable differencesOntogenesis of the Axolemma and Axoglial Relationships in Myelinated Fibers: Electrophysiological and Freeze-Fracture Correlates of Membrane Plasticity
Waxman S, Black J, Foster R. Ontogenesis of the Axolemma and Axoglial Relationships in Myelinated Fibers: Electrophysiological and Freeze-Fracture Correlates of Membrane Plasticity. International Review Of Neurobiology 1983, 24: 433-484. PMID: 6360938, DOI: 10.1016/s0074-7742(08)60226-3.Peer-Reviewed Original Research
1981
Population response characteristics of fiber tracts in central white matter.
Kocsis J, Malenka R, Connors B, Waxman S, Cummins K. Population response characteristics of fiber tracts in central white matter. Progress In Clinical And Biological Research 1981, 52: 17-32. PMID: 7232442.Peer-Reviewed Original Research
1980
Absence of potassium conductance in central myelinated axons
Kocsis J, Waxman S. Absence of potassium conductance in central myelinated axons. Nature 1980, 287: 348-349. PMID: 7421994, DOI: 10.1038/287348a0.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAminopyridinesAnimalsElectric ConductivityNerve Fibers, MyelinatedPotassiumRatsSpinal CordTetraethylammonium CompoundsConceptsCentral myelinated axonsMyelinated axonsAction potentialsPotassium conductanceDorsal column axonsVoltage-clamp experimentsLate outward currentOutward currentsAxonsSodium ion permeabilityLate increaseDepolarization phasePotassium permeabilityAxonal membraneRepolarizationMyelinInitial increaseVoltage-dependent changesSodium inactivationDemyelinationPrevious studiesModulation of Impulse Conduction Along the Axonal Tree
Swadlow H, Kocsis J, Waxman S. Modulation of Impulse Conduction Along the Axonal Tree. Annual Review Of Biophysics And Bioengineering 1980, 9: 143-179. PMID: 6994588, DOI: 10.1146/annurev.bb.09.060180.001043.Peer-Reviewed Original ResearchAction PotentialsAnimalsAxonsElectric ConductivityHumansNeural ConductionNeural InhibitionTime Factors
1975
Observations on impulse conduction along central axons.
Swadlow H, Waxman S. Observations on impulse conduction along central axons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1975, 72: 5156-5159. PMID: 1061101, PMCID: PMC388895, DOI: 10.1073/pnas.72.12.5156.Peer-Reviewed Original ResearchIntegrative Properties and Design Principles of Axons
Waxman S. Integrative Properties and Design Principles of Axons. International Review Of Neurobiology 1975, 18: 1-40. PMID: 1107245, DOI: 10.1016/s0074-7742(08)60032-x.Peer-Reviewed Original Research