2002
Axotomy does not up-regulate expression of sodium channel Nav1.8 in Purkinje cells
Black J, Dusart I, Sotelo C, Waxman S. Axotomy does not up-regulate expression of sodium channel Nav1.8 in Purkinje cells. Brain Research 2002, 101: 126-131. PMID: 12007840, DOI: 10.1016/s0169-328x(02)00200-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsAxotomyCerebellumDisease Models, AnimalFemaleGanglia, SpinalGene Expression RegulationImmunohistochemistryMultiple SclerosisNAV1.8 Voltage-Gated Sodium ChannelNeurons, AfferentNeuropeptidesPurkinje CellsRatsRats, WistarRNA, MessengerSodium ChannelsUp-RegulationZebrafish ProteinsConceptsMultiple sclerosisPurkinje cellsSensory neuron-specific sodium channelsDorsal root ganglion neuronsAberrant expressionSodium channelsHuman multiple sclerosisPrimary sensory neuronsSodium channel Nav1.8Specific sodium channelsCerebellar Purkinje cellsGanglion neuronsSensory neuronsAxotomySurgical modelSodium channel transcriptsExperimental modelCerebellar functionChannel transcriptsNeuronsSitu hybridizationCellsExpressionNav1.8Sclerosis
2001
Acquired channelopathies in nerve injury and MS
Waxman S. Acquired channelopathies in nerve injury and MS. Neurology 2001, 56: 1621-1627. PMID: 11428390, DOI: 10.1212/wnl.56.12.1621.Peer-Reviewed Original ResearchMeSH KeywordsAxonsHumansMultiple SclerosisNeuralgiaParesthesiaPeripheral Nerve InjuriesPeripheral NervesPurkinje CellsSodium ChannelsConceptsNerve injurySodium channelsSensory neuron-specific sodium channelsSodium channel geneChannel genesPeripheral nerve injurySpinal sensory neuronsPathophysiology of MSSubtype-specific drugsDistinct sodium channelsVoltage-gated sodium channelsSpecific sodium channelsAxonal transectionGenetic channelopathyPrototype disorderSensory neuronsPurkinje cellsTherapeutic opportunitiesChannelopathiesAbnormal expressionInjuryMolecular changesHyperexcitabilityCellsTransection
1994
In situ hybridization localization of the Na+ channel β1 subunit mRNA in rat CNS neurons
Oh Y, Sashihara S, Waxman S. In situ hybridization localization of the Na+ channel β1 subunit mRNA in rat CNS neurons. Neuroscience Letters 1994, 176: 119-122. PMID: 7970226, DOI: 10.1016/0304-3940(94)90885-0.Peer-Reviewed Original ResearchConceptsBeta 1 mRNASpinal cordGranule cellsChannel beta 1 subunit (Na beta 1) mRNABeta 1 mRNA expressionDentate granule cellsAdult rat hippocampusCA1 pyramidal cellsRat CNS neuronsBeta 1 subunit mRNASitu hybridization histochemistryCNS neuronsPyramidal cellsRat hippocampusSitu hybridization localizationChannel β1Gray matterHybridization histochemistryPurkinje cellsMRNA expressionSubunit mRNAsModerate expressionDifferent neuronsStrong expressionNeurons