2012
Axonal Protection with Sodium Channel Blocking Agents in Models of Multiple Sclerosis
Black J, Smith K, Waxman S. Axonal Protection with Sodium Channel Blocking Agents in Models of Multiple Sclerosis. 2012, 179-201. DOI: 10.1007/978-1-4614-2218-1_8.Peer-Reviewed Original ResearchExperimental autoimmune encephalomyelitisMultiple sclerosisSodium channelsAspects of MSAcute MS plaquesChronic inactive plaquesSignificant axonal damageImmune cell infiltrationSodium channel blockadeChannel Blocking AgentsSpinal cord axonsWhite matter axonsVoltage-gated sodium channelsAction potential conductionInactive plaquesClinical disabilityAutoimmune encephalomyelitisAxonal protectionNeuroinflammatory disordersNeurological deficitsNeuroprotective therapiesAxonal damageIschemia injuryAxonal degenerationAxonal injury
1993
Molecular dissection of the myelinated axon
Waxman S, Ritchie J. Molecular dissection of the myelinated axon. Annals Of Neurology 1993, 33: 121-136. PMID: 7679565, DOI: 10.1002/ana.410330202.Peer-Reviewed Original ResearchConceptsMyelinated axonsInternodal axon membraneDemyelinated axonsCentral nervous system white matterNervous system white matterRestoration of conductionImportant therapeutic approachSchwann cell processesWhite matter axonsInflux of Ca2Important pathophysiological implicationsGlial cell processesAction potential conductionAxonal excitabilityGlial cellsAnoxic injuryMyelinated fibersTherapeutic approachesAstrocyte processesCell processesPathophysiological implicationsRepetitive firingWhite matterNeurological disordersAction potentials