2024
The evolution of patch-clamp electrophysiology: robotic, multiplex, and dynamic.
Ghovanloo M, Dib-Hajj S, Waxman S. The evolution of patch-clamp electrophysiology: robotic, multiplex, and dynamic. Molecular Pharmacology 2024 PMID: 39164111, DOI: 10.1124/molpharm.124.000954.Peer-Reviewed Original ResearchPatch-clamp techniquePatch-clamp electrophysiologyPatch clampVoltage- and current-clamp modesIon channelsContribution of ion channelsCurrent-clamp modePatch-clamp methodOhm's lawDynamic-clampGating mechanisms of ion channelsMuscle cellsCardiac excitabilityGold standardExcitable cellsReceptorsGate conductionElectrophysiologyNeuronsElectrogenesisSimultaneous recordingCellsHigh-throughput automated platformMechanisms of ion channelsGating mechanism
2017
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview
Alexander S, Kelly E, Marrion N, Peters J, Faccenda E, Harding S, Pawson A, Sharman J, Southan C, Buneman O, Cidlowski J, Christopoulos A, Davenport A, Fabbro D, Spedding M, Striessnig J, Davies J, Collaborators C, Abbracchio M, Aldrich R, Al‐Hosaini K, Arumugam T, Attali B, Bäck M, Barnes N, Bathgate R, Beart P, Becirovic E, Bettler B, Biel M, Birdsall N, Blaho V, Boison D, Bräuner‐osborne H, Bröer S, Bryant C, Burnstock G, Calo G, Catterall W, Ceruti S, Chan S, Chandy K, Chazot P, Chiang N, Chun J, Chung J, Clapham D, Clapp L, Connor M, Cox H, Davies P, Dawson P, Decaen P, Dent G, Doherty P, Douglas S, Dubocovich M, Fong T, Fowler C, Frantz A, Fuller P, Fumagalli M, Futerman A, Gainetdinov R, Gershengorn M, Goldin A, Goldstein S, Goudet C, Gregory K, Grissmer S, Gundlach A, Hagenbuch B, Hamann J, Hammond, Hancox J, Hanson J, Hanukoglu I, Hay D, Hobbs A, Hollenberg A, Holliday N, Hoyer D, Ijzerman A, Inui K, Irving A, Ishii S, Jacobson K, Jan L, Jarvis M, Jensen R, Jockers R, Kaczmarek L, Kanai Y, Karnik S, Kellenberger S, Kemp S, Kennedy C, Kerr I, Kihara Y, Kukkonen J, Larhammar D, Leach K, Lecca D, Leeman S, Leprince J, Lolait S, Macewan D, Maguire J, Marshall F, Mazella J, Mcardle C, Michel M, Miller L, Mitolo V, Mizuno H, Monk P, Mouillac B, Murphy P, Nahon J, Nerbonne J, Nichols C, Norel X, Offermanns S, Palmer L, Panaro M, Papapetropoulos A, Perez‐reyes E, Pertwee R, Pintor S, Pisegna, Plant L, Poyner, Prossnitz E, Pyne S, Ramachandran R, Ren D, Rondard P, Ruzza C, Sackin H, Sanger G, Sanguinetti M, Schild L, Schiöth H, Schulte G, Schulz S, Segaloff D, Serhan C, Singh K, Slesinger P, Snutch T, Sobey C, Stewart G, Stoddart L, Summers R, Szabo C, Thwaites D, Toll L, Trimmer J, Tucker S, Vaudry H, Verri T, Vilargada J, Waldman, Ward D, Waxman S, Wei A, Willars G, Wong S, Woodruff T, Wulff H, Ye R, Yung Y, Zajac J. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. British Journal Of Pharmacology 2017, 174: s1-s16. PMID: 29055037, PMCID: PMC5650665, DOI: 10.1111/bph.13882.Peer-Reviewed Original ResearchConceptsBest available pharmacological toolsOfficial IUPHAR classificationAvailable pharmacological toolsDrug targetsIon channelsG protein-coupled receptorsHuman drug targetsLigand-gated ion channelsProtein-coupled receptorsVoltage-gated ion channelsNomenclature guidanceClinical pharmacologyCatalytic receptorsSelective pharmacologyOpen access knowledgebaseNuclear hormone receptorsPharmacological toolsHormone receptorsPrevious GuidesReceptorsLandscape formatPharmacologyBiennial publicationConcise guideRelated targets
2015
The Concise Guide to PHARMACOLOGY 2015/16: Overview
Alexander S, Kelly E, Marrion N, Peters J, Benson H, Faccenda E, Pawson A, Sharman J, Southan C, Buneman O, Catterall W, Cidlowski J, Davenport A, Fabbro D, Fan G, McGrath J, Spedding M, Davies J, Collaborators C, Aldrich R, Attali B, Bäck M, Barnes N, Bathgate R, Beart P, Becirovic E, Biel M, Birdsall N, Boison D, Bräuner‐Osborne H, Bröer S, Bryant C, Burnstock G, Burris T, Cain D, Calo G, Chan S, Chandy K, Chiang N, Christakos S, Christopoulos A, Chun J, Chung J, Clapham D, Connor M, Coons L, Cox H, Dautzenberg F, Dent G, Douglas S, Dubocovich M, Edwards D, Farndale R, Fong T, Forrest D, Fowler C, Fuller P, Gainetdinov R, Gershengorn M, Goldin A, Goldstein S, Grimm S, Grissmer S, Gundlach A, Hagenbuch B, Hammond, Hancox J, Hartig S, Hauger R, Hay D, Hébert T, Hollenberg A, Holliday N, Hoyer D, Ijzerman A, Inui K, Ishii S, Jacobson K, Jan L, Jarvis G, Jensen R, Jetten A, Jockers R, Kaczmarek L, Kanai Y, Kang H, Karnik S, Kerr I, Korach K, Lange C, Larhammar D, Leeb‐Lundberg F, Leurs R, Lolait S, Macewan D, Maguire J, May J, Mazella J, Mcardle C, Mcdonnell D, Michel M, Miller L, Mitolo V, Monie T, Monk P, Mouillac B, Murphy P, Nahon J, Nerbonne J, Nichols C, Norel X, Oakley R, Offermanns S, Palmer L, Panaro M, Perez‐Reyes E, Pertwee R, Pike J, Pin J, Pintor S, Plant L, Poyner, Prossnitz E, Pyne S, Ren D, Richer J, Rondard P, Ross R, Sackin H, Safi R, Sanguinetti M, Sartorius C, Segaloff D, Sladek F, Stewart G, Stoddart L, Striessnig J, Summers R, Takeda Y, Tetel M, Toll L, Trimmer J, Tsai M, Tsai S, Tucker S, Usdin T, Vilargada J, Vore M, Ward D, Waxman S, Webb P, Wei A, Weigel N, Willars G, Winrow C, Wong S, Wulff H, Ye R, Young M, Zajac J. The Concise Guide to PHARMACOLOGY 2015/16: Overview. British Journal Of Pharmacology 2015, 172: 5729-5743. PMID: 26650438, PMCID: PMC4718217, DOI: 10.1111/bph.13347.Peer-Reviewed Original ResearchConceptsBest available pharmacological toolsOfficial IUPHAR classificationAvailable pharmacological toolsDrug targetsIon channelsG protein-coupled receptorsHuman drug targetsLigand-gated ion channelsProtein-coupled receptorsVoltage-gated ion channelsNomenclature guidanceIUPHAR-DBMajor pharmacological targetCatalytic receptorsOpen access knowledgebaseNuclear hormone receptorsPharmacological targetsPharmacological toolsHormone receptorsNC-IUPHARPrevious GuidesReceptorsLandscape formatConcise guideRelated targets
2000
Development of Glutamatergic Synaptic Activity in Cultured Spinal Neurons
Robert A, Howe J, Waxman S. Development of Glutamatergic Synaptic Activity in Cultured Spinal Neurons. Journal Of Neurophysiology 2000, 83: 659-670. PMID: 10669482, DOI: 10.1152/jn.2000.83.2.659.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsCells, CulturedExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsFetusGlutamic AcidMagnesiumMembrane PotentialsNeuronsPatch-Clamp TechniquesQuinoxalinesRatsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateSpinal CordSynapsesTetrodotoxinConceptsSpontaneous synaptic activityCultured spinal neuronsSynaptic activitySpinal neuronsGlutamatergic synapsesSynaptic currentsGlutamatergic synaptic activityIsoxazolepropionic acid (AMPA) receptorsSpontaneous synaptic currentsOlder neuronsSynaptic NMDARsExogenous glutamateNMDARAcid receptorsSynaptic regionNeuronsReceptor openingSignificant increaseTime courseSynapsesSequence of eventsActivityWeeksCourseReceptors