1997
Pharmacological Characterization of Na+ Influx via Voltage-Gated Na+ Channels in Spinal Cord Astrocytes
Rose C, Ransom B, Waxman S. Pharmacological Characterization of Na+ Influx via Voltage-Gated Na+ Channels in Spinal Cord Astrocytes. Journal Of Neurophysiology 1997, 78: 3249-3258. PMID: 9405543, DOI: 10.1152/jn.1997.78.6.3249.Peer-Reviewed Original ResearchConceptsSpinal cordChannel inactivationCultured spinal cordSpinal cord astrocytesEffect of veratridineSodium-binding benzofuranMicroM tetrodotoxinPharmacological characterizationAgonist kainatePharmacological inhibitionTetrodotoxinAstrocytesVeratridineCordMembrane depolarizationKainateImportant functional roleInfluxFunctional roleInhibitionCellsProminent pathwayATPase activityInactivationBaseline
1996
White Matter Stroke: Autoprotective Mechanisms with Therapeutic Implications
Fern R, Ransom B, Waxman S. White Matter Stroke: Autoprotective Mechanisms with Therapeutic Implications. Cerebrovascular Diseases 1996, 6: 59-65. DOI: 10.1159/000107999.Peer-Reviewed Original ResearchWhite matterAnoxic injuryWhite matter strokeIncidence of strokeCNS white matterLevels of GABARecovery of functionResult of anoxiaIrreversible dysfunctionAnoxic insultPharmacological strategiesIrreversible injuryTherapeutic implicationsEndogenous storesExogenous GABAInjuryGABAAutoprotective mechanismsStrokeIntracellular eventsExtracellular spaceCa2Protective treatmentAdenosineInflux
1991
Na+‐Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter
Stys P, Waxman S, Ransom B. Na+‐Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter. Annals Of Neurology 1991, 30: 375-380. PMID: 1952825, DOI: 10.1002/ana.410300309.Peer-Reviewed Original ResearchConceptsWhite matterIsolated rat optic nerveCentral nervous system white matterNervous system white matterWhite matter injuryRat optic nerveMammalian central nervous systemSevere neurological impairmentCompound action potentialType of injuryCentral nervous systemFunctional recoveryOptic nervePharmacological blockadeNeurological impairmentAnoxic injuryIrreversible injuryNervous systemAction potentialsInjuryInfluxCa2Critical mechanismCellsNerve
1990
Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia
Stys P, Ransom B, Waxman S. Effects of polyvalent cations and dihydropyridine calcium channel blockers on recovery of CNS white matter from anoxia. Neuroscience Letters 1990, 115: 293-299. PMID: 2234507, DOI: 10.1016/0304-3940(90)90471-k.Peer-Reviewed Original ResearchConceptsAnoxic injuryChannel blockersWhite matterMammalian central white matterDihydropyridine calcium channel blockerChannel blockers Mn2Irreversible anoxic injuryCalcium channel blockersCNS white matterCompound action potentialCentral white matterDihydropyridine classOrganic Ca2Inorganic Ca2Extracellular Ca2Action potentialsNerve modelMin periodBlockersInjuryFunctional integrityConventional Ca2Ca2InfluxIntracellular compartments