2012
Axonal Protection with Sodium Channel Blocking Agents in Models of Multiple Sclerosis
Black J, Smith K, Waxman S. Axonal Protection with Sodium Channel Blocking Agents in Models of Multiple Sclerosis. 2012, 179-201. DOI: 10.1007/978-1-4614-2218-1_8.Peer-Reviewed Original ResearchExperimental autoimmune encephalomyelitisMultiple sclerosisSodium channelsAspects of MSAcute MS plaquesChronic inactive plaquesSignificant axonal damageImmune cell infiltrationSodium channel blockadeChannel Blocking AgentsSpinal cord axonsWhite matter axonsVoltage-gated sodium channelsAction potential conductionInactive plaquesClinical disabilityAutoimmune encephalomyelitisAxonal protectionNeuroinflammatory disordersNeurological deficitsNeuroprotective therapiesAxonal damageIschemia injuryAxonal degenerationAxonal injury
2004
Chapter 41 Ischemic White Matter Damage
Stys P, Waxman S. Chapter 41 Ischemic White Matter Damage. 2004, 985-1007. DOI: 10.1016/b978-012439510-7/50094-2.Peer-Reviewed Original ResearchIschemic white matter injuryIschemic white matter damageIschemic CNS injuryMore chronic statesWhite matter injuryWhite matter damageMammalian white matterClinical disabilityAcute strokePeriventricular leukomalaciaAxonal disordersCerebral palsyIschemic damageVascular dementiaMultiple sclerosisCNS injuryMatter damageSocioeconomic burdenMyelinated fibersSuccessful therapyChronic stateWhite matterIrreversible compromiseDeleterious eventsWestern populations