2023
Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons
Ghovanloo M, Effraim P, Yuan J, Schulman B, Jacobs D, Dib-Hajj S, Waxman S. Nav1.7 P610T mutation in two siblings with persistent ocular pain after corneal axon transection: impaired slow inactivation and hyperexcitable trigeminal neurons. Journal Of Neurophysiology 2023, 129: 609-618. PMID: 36722722, PMCID: PMC9988530, DOI: 10.1152/jn.00457.2022.Peer-Reviewed Original ResearchConceptsPersistent ocular painTrigeminal ganglion neuronsOcular painCorneal refractive surgeryGanglion neuronsRefractive surgeryAxonal injurySlow inactivationHuman pain modelTrigeminal afferent nervesTrigeminal ganglion axonsSmall subgroupPain-related disordersEffects of injurySodium channel Nav1.7Channel slow inactivationEye painPostoperative painMost patientsPain modelAfferent nervesPersistent painTrigeminal neuronsNav1.7 mutationAxon transection
2020
Say Cheese: Structure of the Cardiac Electrical Engine Is Captured
Ghovanloo MR, Ruben PC. Say Cheese: Structure of the Cardiac Electrical Engine Is Captured. Trends In Biochemical Sciences 2020, 45: 369-371. PMID: 32311330, DOI: 10.1016/j.tibs.2020.02.003.Peer-Reviewed Original Research
2018
A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels
Ghovanloo MR, Abdelsayed M, Peters CH, Ruben PC. A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels. Scientific Reports 2018, 8: 6304. PMID: 29674667, PMCID: PMC5908869, DOI: 10.1038/s41598-018-24719-y.Peer-Reviewed Original ResearchConceptsPeriodic paralysisSkeletal muscle voltageSkeletal muscle channelopathiesHypokalemic periodic paralysisSteady-state fast inactivationLow potassium levelsAutosomal dominant mutationsEpisodic attacksIntense exercisePhysical activityMuscle channelopathiesBlood acidosisCommon triggerPotassium levelsAction potential modelingParalysisSodium channelsMuscular contractionSkeletal muscleMyotoniaPhenotype correlationLate currentPatientsExtracellular pHFast inactivation