Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes
Fouda MA, Ghovanloo M, Ruben PC. Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes. The Journal Of Physiology 2022, 600: 2835-2851. PMID: 35436004, DOI: 10.1113/jp282768.Peer-Reviewed Original ResearchConceptsLate sodium currentSodium currentSkeletal muscleAction potential durationRepetitive action potentialsVoltage-gated sodium channelsSeizure disorderTrigger seizuresPeripheral nervesPotential durationSodium channelopathiesAction potentialsSodium channelsChannel inactivationPainDysfunctionMyotoniaMuscleHeartGating propertiesNerveSeizuresArrhythmiasChannelopathiesDisease