Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death
Ghovanloo MR, Atallah J, Escudero CA, Ruben PC. Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death. Frontiers In Physiology 2020, 11: 610436. PMID: 33414724, PMCID: PMC7783455, DOI: 10.3389/fphys.2020.610436.Peer-Reviewed Original ResearchSudden cardiac deathCatecholaminergic polymorphic ventricular tachycardiaAtrial action potential durationCPVT-like phenotypeOnset of symptomsPolymorphic ventricular tachycardiaPrimary electrical disordersStrong family historyCardiac electrical propertiesAction potential durationNovel SCN5A mutationUse-dependent inactivationCardiac ion channelsO'Hara-Rudy modelCardiac deathVentricular arrhythmiasSCD casesTachy-arrhythmiasVentricular tachycardia