Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels
Ghovanloo MR, Abdelsayed M, Ruben PC. Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels. Frontiers In Pharmacology 2016, 7: 39. PMID: 26973526, PMCID: PMC4771766, DOI: 10.3389/fphar.2016.00039.Peer-Reviewed Original ResearchEffects of amiodaronePro-arrhythmic effectsAntiarrhythmic drugsN-desethylamiodaroneLate sodium currentPotent antiarrhythmic drugDrug-mediated effectsAdverse side effectsAtrial fibrillationPharmacologic profileQT intervalAmiodaroneSide effectsCardiac voltageWindow currentSodium currentClass ISodium channelsHigh efficacyDrugsPeak conductanceNav1.5Similar profilesTorsadesTachycardia