pH Modulation of Voltage-Gated Sodium Channels
Peters CH, Ghovanloo MR, Gershome C, Ruben PC. pH Modulation of Voltage-Gated Sodium Channels. Handbook Of Experimental Pharmacology 2018, 246: 147-160. PMID: 29460150, DOI: 10.1007/164_2018_99.Peer-Reviewed Original ResearchConceptsElectrical diseaseSodium channelsChannel gatingDisease-causing mutantsSodium channel poreTransient sodium currentModulation of VoltageIschemic strokeNon-inactivating channelsSkeletal muscle sodium channelsAcute symptomsCocaine ingestionCardiac ischemiaSodium channel mutationsMuscle sodium channelsSodium currentIsoform specificitySodium channel gatingTissue-level effectsPathophysiological conditionsChannel mutationsSkeletal muscleDiseaseCardiac tissueChannel pore