Antibodies against the NG2 Proteoglycan Promote the Regeneration of Sensory Axons within the Dorsal Columns of the Spinal Cord
Tan A, Colletti M, Rorai A, Skene J, Levine J. Antibodies against the NG2 Proteoglycan Promote the Regeneration of Sensory Axons within the Dorsal Columns of the Spinal Cord. Journal Of Neuroscience 2006, 26: 4729-4739. PMID: 16672645, PMCID: PMC6674154, DOI: 10.1523/jneurosci.3900-05.2006.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntibodies, MonoclonalAntigensAxonsBlotting, WesternCD11b AntigenDisease Models, AnimalEctodysplasinsFemaleFibronectinsFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinImmunoprecipitationLaminectomyMembrane ProteinsMyelin ProteinsNerve RegenerationNeurogliaNeurons, AfferentNogo ProteinsPeripheral Nervous System DiseasesProteoglycansRatsRats, Sprague-DawleySpinal Cord InjuriesTime FactorsTumor Necrosis FactorsConceptsAnti-NG2 antibodiesNerve conditioning lesionConditioning lesionSpinal cordSensory axonsAxonal regenerationAdult rat spinal cordSite of CNS injuryRegeneration of sensory axonsNon-neutralizing antibodiesRat spinal cordSensory axon regenerationTransected adult rat spinal cordGlial scarAxon growth in vitroIntrinsic growth capacityAscending sensory axonsGrowth in vitroInhibit axon regenerationExtrinsic inhibitionAntibody treatmentDorsal columnsDorsal rootsNG2 immunoreactivityAdult neurons