2023
Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia
Benson C, King J, Kauer S, Waxman S, Tan A. Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia. Journal Of Neurophysiology 2023, 130: 1358-1366. PMID: 37877184, PMCID: PMC10972632, DOI: 10.1152/jn.00234.2023.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRate-dependent depressionTripartite synapsesGLT-1Astrocytic GLT-1 expressionChronic neurological complicationsGLT-1 expressionAstrocyte involvementChronic spasticityUninjured shamsNeurological complicationsNeuropathic painHyperexcitability disordersH-reflexPSD-95 proteinReactive astrocytesVentral hornCord injuryMuscle toneAstrocytes' roleSpinal cordSpinal circuitsSynaptic transmissionHyperreflexiaSpasticity
2011
Spinal cord injury, dendritic spine remodeling, and spinal memory mechanisms
Tan AM, Waxman SG. Spinal cord injury, dendritic spine remodeling, and spinal memory mechanisms. Experimental Neurology 2011, 235: 142-151. PMID: 21925174, DOI: 10.1016/j.expneurol.2011.08.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDendritic SpinesMemoryNeuralgiaNeuronal PlasticityNeuronsSpinal Cord InjuriesSynapsesConceptsSpinal cord injuryNeuropathic painDendritic spinesChronic painCord injuryNervous systemWide dynamic range neuronsNociceptive dorsal horn neuronsDorsal horn neuronsDendritic spine remodelingRange neuronsCentral sensitizationSpinal cordSpine remodelingPainSynaptic potentiationPain researchInjuryMore effective strategiesAberrant changesLong-term memory storageSpineStructural substrateSynaptic modelNeurons
2009
Dendritic Spine Remodeling After Spinal Cord Injury Alters Neuronal Signal Processing
Tan AM, Choi JS, Waxman SG, Hains BC. Dendritic Spine Remodeling After Spinal Cord Injury Alters Neuronal Signal Processing. Journal Of Neurophysiology 2009, 102: 2396-2409. PMID: 19692517, DOI: 10.1152/jn.00095.2009.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injurySynaptic transmissionDorsal horn nociceptive neuronsFrequency-following abilityDendritic spine remodelingGeneration of painAction potential activationDendritic spine morphologyDendritic spine shapeAbnormal painCentral sensitizationNociceptive neuronsSpine remodelingPostsynaptic neuronsDendritic spinesSpine morphologyInput-output functionPainSoma resultsInjurySpine shapeNeuronal statesNeuronsPotential activation