2007
Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state
Tan A, Petruska J, Mendell L, Levine J. Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state. Experimental Neurology 2007, 206: 257-268. PMID: 17585905, PMCID: PMC3103885, DOI: 10.1016/j.expneurol.2007.05.013.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDorsal columnsChronic pathophysiological stateNerve conditioning lesionConditioning lesionRegenerating axonsCord injurySensory afferentsInjury siteFrequency-following abilityInfusion of antibodiesPathophysiological statesIntrinsic growth stateExperimental spinal cord injuryRegenerating sensory axonsReduced conduction velocityIntrinsic growth capacitySensory axon growthAxonal growthGrowth inhibitory effectSensory neuronsSpinal cordCombinatorial treatmentInhibit axonal growthRepetitive stimuli
2005
NG2: a component of the glial scar that inhibits axon growth
Tan A, Zhang W, Levine J. NG2: a component of the glial scar that inhibits axon growth. Journal Of Anatomy 2005, 207: 717-725. PMID: 16367799, PMCID: PMC1571583, DOI: 10.1111/j.1469-7580.2005.00452.x.Peer-Reviewed Original ResearchConceptsOligodendrocyte precursor cellsGlial scarNG2-expressing oligodendrocyte precursor cellsGrowth-inhibitory environmentSpinal cord resultsCord resultsInhibit axonal growthCNS injuryInjury siteSurface of oligodendrocyte precursor cellsPrecursor cellsAxonal regenerationAxonal regrowthChondroitin sulphate proteoglycansInjury to brainNG2ScarsInjuryAxonal growth