Selective Corticospinal Tract Injury in the Rat Induces Primary Afferent Fiber Sprouting in the Spinal Cord and Hyperreflexia
Tan A, Chakrabarty S, Kimura H, Martin J. Selective Corticospinal Tract Injury in the Rat Induces Primary Afferent Fiber Sprouting in the Spinal Cord and Hyperreflexia. Journal Of Neuroscience 2012, 32: 12896-12908. PMID: 22973013, PMCID: PMC3499628, DOI: 10.1523/jneurosci.6451-11.2012.Peer-Reviewed Original ResearchConceptsCorticospinal tract injurySpinal cordCorticospinal tractProprioceptive afferentsAfferent fiber sproutingGray matter regionsFrequency-dependent depressionCorticospinal tract terminalsCervical spinal cordMechanisms of maladaptive plasticityMatter regionsSpinal cord projectionsSpinal cord injuryPyramidal tract sectionTract injurySpared sideAdult ratsFiber sproutingAfferent terminalsSpinal targetsMicroglial densityMuscle afferentsSpinal sensorimotor circuitsMaladaptive plasticityAfferents