2018
Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus
Yasumoto Y, Miyazaki H, Ogata M, Kagawa Y, Yamamoto Y, Islam A, Yamada T, Katagiri H, Owada Y. Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus. Molecular Neurobiology 2018, 55: 9016-9028. PMID: 29623545, DOI: 10.1007/s12035-018-1033-9.Peer-Reviewed Original ResearchConceptsFabp7 KO miceFatty Acid Binding Protein 7Arcuate nucleusHypothalamic arcuate nucleusKO miceFood intakeMedian eminenceFatty acid-binding protein 7Energy homeostasisWeight gainSingle leptin injectionHigh-fat dietNon-neuronal cell typesWild-type miceProtein 7Systemic energy homeostasisLeptin-induced activationPrimary astrocyte culturesNeuronal leptinHypothalamic astrocytesWT miceLeptin injectionObese miceHypothalamic sitesLeptin treatment
2013
Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells
Sharifi K, Ebrahimi M, Kagawa Y, Islam A, Tuerxun T, Yasumoto Y, Hara T, Yamamoto Y, Miyazaki H, Tokuda N, Yoshikawa T, Owada Y. Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells. Cell And Tissue Research 2013, 354: 683-695. PMID: 24114376, DOI: 10.1007/s00441-013-1730-7.Peer-Reviewed Original ResearchConceptsLineage cellsOligodendrocyte lineage cellsOligodendrocyte progenitor cellsCultured oligodendrocyte progenitor cellsCell populationsOPCs/oligodendrocytesSignal transductionGene transcriptionKey intracellular moleculesOligodendrocyte lineage markersExpression of FABP5Differential expressionRegulatory roleIntracellular moleculesDifferentiation mediumFABP7FABP5FABP7 expressionLineage markersProgenitor cellsOligodendrocyte lineageMixed cortical culturesBrdU uptakeExpressionCentral role
2011
FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation
Sharifi K, Morihiro Y, Maekawa M, Yasumoto Y, Hoshi H, Adachi Y, Sawada T, Tokuda N, Kondo H, Yoshikawa T, Suzuki M, Owada Y. FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation. Histochemistry And Cell Biology 2011, 136: 501. PMID: 21938553, PMCID: PMC3192944, DOI: 10.1007/s00418-011-0865-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntigensAstrocytesCell ProliferationCells, CulturedCerebral CortexDisease Models, AnimalFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFatty Acids, Omega-3Gene ExpressionGliosisHomeostasisMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeural Stem CellsOligodendrogliaProteoglycansWounds, StabConceptsFabp7 KO miceGlial cellsReactive gliosisFABP7 expressionBrain-type fatty acid-binding proteinProliferation of astrocytesExpression of FABP7Cellular fatty acid homeostasisWild-type miceGlial cell proliferationOligodendrocyte progenitor cellsWild-type astrocytesFatty acid-binding proteinRole of FABP7Fatty acid homeostasisFatty acid incorporationNeural stem cellsReactive astrocytesNormal cortexAstrocyte proliferationContralateral sideInjury modelAcid-binding proteinBrain pathologyBrain cortex