2016
Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells
Yasumoto Y, Miyazaki H, Vaidyan LK, Kagawa Y, Ebrahimi M, Yamamoto Y, Ogata M, Katsuyama Y, Sadahiro H, Suzuki M, Owada Y. Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells. PLOS ONE 2016, 11: e0147717. PMID: 26808816, PMCID: PMC4726602, DOI: 10.1371/journal.pone.0147717.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCell MovementCell ProliferationCeruleninFatty Acid SynthasesFemaleGene Expression Regulation, NeoplasticGliomaHumansMaleMiddle AgedNeoplastic Stem CellsTumor Cells, CulturedConceptsFatty acid synthaseGlioma stem cellsStem cellsCellular lipid metabolismCellular metabolic changesKey lipogenic enzymesPatient-derived glioma stem cellsLipid biosynthesisFatty acid binding proteinAcid binding proteinPharmacological inhibitorsSynthesis assayBinding proteinAcid synthaseCerulenin treatmentGlial fibrillary acidic protein (GFAP) expressionGSC stemnessProtein expressionCancer cellsDe novo lipogenesisLipogenic enzymesImmunocytochemical analysisMarker nestinStemness markersDecrease expression
2013
Fatty acid binding protein 7 as a marker of glioma stem cells
Morihiro Y, Yasumoto Y, Vaidyan LK, Sadahiro H, Uchida T, Inamura A, Sharifi K, Ideguchi M, Nomura S, Tokuda N, Kashiwabara S, Ishii A, Ikeda E, Owada Y, Suzuki M. Fatty acid binding protein 7 as a marker of glioma stem cells. Pathology International 2013, 63: 546-553. PMID: 24274717, DOI: 10.1111/pin.12109.Peer-Reviewed Original ResearchConceptsGlioblastoma stem cellsPatient-derived GSC linesGlioma surgical specimensExpression of FABP7Stem cellsAggressive brain tumorGlioma stem cellsNeural stem cellsPoor prognosisFatty acidsMajority of glioblastomasSurgical specimensFABP7 expressionAnaplastic astrocytomaBrain tumorsDiffuse astrocytomasGlioma diagnosisTumor cellsFABP7Western blottingAddition of serumKnown markerGlioblastomaProtein 7GSC lines