2018
Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus
Yasumoto Y, Miyazaki H, Ogata M, Kagawa Y, Yamamoto Y, Islam A, Yamada T, Katagiri H, Owada Y. Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus. Molecular Neurobiology 2018, 55: 9016-9028. PMID: 29623545, DOI: 10.1007/s12035-018-1033-9.Peer-Reviewed Original ResearchConceptsFabp7 KO miceFatty Acid Binding Protein 7Arcuate nucleusHypothalamic arcuate nucleusKO miceFood intakeMedian eminenceFatty acid-binding protein 7Energy homeostasisWeight gainSingle leptin injectionHigh-fat dietNon-neuronal cell typesWild-type miceProtein 7Systemic energy homeostasisLeptin-induced activationPrimary astrocyte culturesNeuronal leptinHypothalamic astrocytesWT miceLeptin injectionObese miceHypothalamic sitesLeptin treatment
2015
Fatty acid‐binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin‐1
Kagawa Y, Yasumoto Y, Sharifi K, Ebrahimi M, Islam A, Miyazaki H, Yamamoto Y, Sawada T, Kishi H, Kobayashi S, Maekawa M, Yoshikawa T, Takaki E, Nakai A, Kogo H, Fujimoto T, Owada Y. Fatty acid‐binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin‐1. Glia 2015, 63: 780-794. PMID: 25601031, DOI: 10.1002/glia.22784.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesCaveolaeCaveolin 1Cell SurvivalCells, CulturedCerebral CortexCholesterolCytokinesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGene Expression ProfilingGene Expression RegulationGlial Cell Line-Derived Neurotrophic FactorLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsOligonucleotide Array Sequence AnalysisSignal TransductionTransduction, GeneticConceptsLipid raft functionCaveolin-1Raft functionLipid raftsFatty Acid Binding Protein 7Function of caveolaeReceptor-mediated signal transductionMitogen-activated protein kinaseRole of FABP7Toll-like receptor 4Caveolin-1 expressionExtracellular stimuliCavin-1Protein bindsSignal transductionCaveolin-2Flotillin-1Protein kinaseReceptor alpha 1Transcriptional levelLong-chain fatty acidsLipid dynamicsWild-type astrocytesLipid homeostasisTLR4 recruitment