2013
Fatty acid binding protein 7 as a marker of glioma stem cells
Morihiro Y, Yasumoto Y, Vaidyan LK, Sadahiro H, Uchida T, Inamura A, Sharifi K, Ideguchi M, Nomura S, Tokuda N, Kashiwabara S, Ishii A, Ikeda E, Owada Y, Suzuki M. Fatty acid binding protein 7 as a marker of glioma stem cells. Pathology International 2013, 63: 546-553. PMID: 24274717, DOI: 10.1111/pin.12109.Peer-Reviewed Original ResearchConceptsGlioblastoma stem cellsPatient-derived GSC linesGlioma surgical specimensExpression of FABP7Stem cellsAggressive brain tumorGlioma stem cellsNeural stem cellsPoor prognosisFatty acidsMajority of glioblastomasSurgical specimensFABP7 expressionAnaplastic astrocytomaBrain tumorsDiffuse astrocytomasGlioma diagnosisTumor cellsFABP7Western blottingAddition of serumKnown markerGlioblastomaProtein 7GSC linesDifferential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells
Sharifi K, Ebrahimi M, Kagawa Y, Islam A, Tuerxun T, Yasumoto Y, Hara T, Yamamoto Y, Miyazaki H, Tokuda N, Yoshikawa T, Owada Y. Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells. Cell And Tissue Research 2013, 354: 683-695. PMID: 24114376, DOI: 10.1007/s00441-013-1730-7.Peer-Reviewed Original ResearchConceptsLineage cellsOligodendrocyte lineage cellsOligodendrocyte progenitor cellsCultured oligodendrocyte progenitor cellsCell populationsOPCs/oligodendrocytesSignal transductionGene transcriptionKey intracellular moleculesOligodendrocyte lineage markersExpression of FABP5Differential expressionRegulatory roleIntracellular moleculesDifferentiation mediumFABP7FABP5FABP7 expressionLineage markersProgenitor cellsOligodendrocyte lineageMixed cortical culturesBrdU uptakeExpressionCentral role
2011
FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation
Sharifi K, Morihiro Y, Maekawa M, Yasumoto Y, Hoshi H, Adachi Y, Sawada T, Tokuda N, Kondo H, Yoshikawa T, Suzuki M, Owada Y. FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation. Histochemistry And Cell Biology 2011, 136: 501. PMID: 21938553, PMCID: PMC3192944, DOI: 10.1007/s00418-011-0865-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntigensAstrocytesCell ProliferationCells, CulturedCerebral CortexDisease Models, AnimalFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFatty Acids, Omega-3Gene ExpressionGliosisHomeostasisMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeural Stem CellsOligodendrogliaProteoglycansWounds, StabConceptsFabp7 KO miceGlial cellsReactive gliosisFABP7 expressionBrain-type fatty acid-binding proteinProliferation of astrocytesExpression of FABP7Cellular fatty acid homeostasisWild-type miceGlial cell proliferationOligodendrocyte progenitor cellsWild-type astrocytesFatty acid-binding proteinRole of FABP7Fatty acid homeostasisFatty acid incorporationNeural stem cellsReactive astrocytesNormal cortexAstrocyte proliferationContralateral sideInjury modelAcid-binding proteinBrain pathologyBrain cortex