Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit
Lavoie S, Chen Y, Dalton TP, Gysin R, Cuénod M, Steullet P, Q. K. Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit. Journal Of Neurochemistry 2009, 108: 1410-1422. PMID: 19183254, DOI: 10.1111/j.1471-4159.2009.05908.x.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntioxidantsAstrocytesCell SurvivalCells, CulturedCerebral CortexCurcuminDose-Response Relationship, DrugEmbryo, MammalianEnzyme InhibitorsGene ExpressionGlutamate-Cysteine LigaseGlutathioneHydroquinonesMiceMice, Inbred C57BLMice, KnockoutNeuronsProtein SubunitsQuercetinUp-RegulationConceptsGlutamate-cysteine ligaseGCL activityRate-limiting synthesizing enzymeRedox regulatorCatalytic subunitGSH levelsGene expressionCysteine ligaseGlutamate cysteine ligase modifierModifier subunitCell deathCell typesGSH synthesisEnzymeNeurodegenerative diseasesCultured neuronsGCLMSubunitsMRNA levelsSynthesizing enzymesGSHLower GSHAbility of curcuminExpressionLigase