2024
Acyl-CoA Synthetase Medium-Chain Family Member 5-Mediated Fatty Acid Metabolism Dysregulation Promotes the Progression of Hepatocellular Carcinoma.
Yang L, Pham K, Xi Y, Jiang S, Robertson KD, Liu C. Acyl-CoA Synthetase Medium-Chain Family Member 5-Mediated Fatty Acid Metabolism Dysregulation Promotes the Progression of Hepatocellular Carcinoma. Am J Pathol 2024, 194: 1951-1966. PMID: 39069168, DOI: 10.1016/j.ajpath.2024.07.002.Peer-Reviewed Original ResearchOral 8-aminoguanine against age-related retinal degeneration.
Chen Y, Vats A, Xi Y, Wolf-Johnston A, Clinger O, Arbuckle R, Dermond C, Li J, Stolze D, Sahel JA, Jackson E, Birder L. Oral 8-aminoguanine against age-related retinal degeneration. Res Sq 2024 PMID: 38765984, DOI: 10.21203/rs.3.rs-4022389/v1.Peer-Reviewed Original Research In Press
2023
The 18th amino acid glycine plays an essential role in maintaining the structural stabilities of γS-crystallin linking with congenital cataract.
Zhu S, Xi Y, Xu J, Hu L, Luo C, Yao K, Chen X. The 18th amino acid glycine plays an essential role in maintaining the structural stabilities of γS-crystallin linking with congenital cataract. Int J Biol Macromol 2023, 251: 126339. PMID: 37586630, DOI: 10.1016/j.ijbiomac.2023.126339.Peer-Reviewed Original Research
2022
Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure.
Peng G, Xi Y, Bellini C, Pham K, Zhuang ZW, Yan Q, Jia M, Wang G, Lu L, Tang MS, Zhao H, Wang H. Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure. American Journal Of Cancer Research 2022, 12: 3679-3692. PMID: 36119846, PMCID: PMC9442002.Peer-Reviewed Original ResearchElectronic cigarette exposureCigarette exposureMale ApoE-/- miceApoE-/- miceCytokine mRNA expressionPoor health outcomesWhite blood cellsElectronic cigarette useDose-dependent mannerE-cigarette aerosolAerosol inhalationCigarette smokingActivation of MAPKHigher nicotine concentrationsMAPK pathway activationCell-damaging effectsCpG sitesHealth outcomesCigarette useMRNA expressionNicotine concentrationsPathway activationSignificant CpG sitesBlood cellsSignificant alterationsCelastrol regulates the oligomeric state and chaperone activity of αB-crystallin linked with protein homeostasis in the lens.
Wang H, Tian Q, Zhang Y, Xi Y, Hu L, Yao K, Li J, Chen X. Celastrol regulates the oligomeric state and chaperone activity of αB-crystallin linked with protein homeostasis in the lens. Fundam Res 2022, 4: 394-400. PMID: 38933503, DOI: 10.1016/j.fmre.2022.05.012.Peer-Reviewed Original ResearchNonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa.
Vats A, Xi Y, Feng B, Clinger OD, St Leger AJ, Liu X, Ghosh A, Dermond CD, Lathrop KL, Tochtrop GP, Picaud S, Chen Y. Nonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa. JCI Insight 2022, 7 PMID: 35472194, DOI: 10.1172/jci.insight.153717.Peer-Reviewed Original ResearchEmerging Trends in the Pathological Research of Human Papillomavirus-positive Oropharyngeal Squamous Cell Carcinoma
Crane J, Shi Q, Xi Y, Lai J, Pham K, Wang H. Emerging Trends in the Pathological Research of Human Papillomavirus-positive Oropharyngeal Squamous Cell Carcinoma. Journal Of Clinical And Translational Pathology 2022, 2: 31-36. PMID: 36275841, PMCID: PMC9585478, DOI: 10.14218/jctp.2022.00004.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaSquamous cell carcinomaCell carcinomaHuman papillomavirusHuman papillomavirus-positive oropharyngeal squamous cell carcinomaHPV-positive oropharyngeal squamous cell carcinomaHPV-negative oropharyngeal squamous cell carcinomaActive human papillomavirusNew targetsLong-term survivalPotential new targetsDefinitive treatmentHPV 16Treatment optionsSurvival prognosisTumor prognosisAdvanced stageHealth responsePrecision treatmentPrecision medicinePatientsCarcinomaPrognosisTreatmentPathological researchPharmacological strategies for treating misfolded rhodopsin-associated autosomal dominant retinitis pigmentosa.
Xi Y, Chen Y. Pharmacological strategies for treating misfolded rhodopsin-associated autosomal dominant retinitis pigmentosa. Neural Regen Res 2022, 17: 110-112. PMID: 34100444, DOI: 10.4103/1673-5374.314306.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
A novel F30S mutation in γS-crystallin causes autosomal dominant congenital nuclear cataract by increasing susceptibility to stresses.
Wang KJ, Liao XY, Lin K, Xi YB, Wang S, Wan XH, Yan YB. A novel F30S mutation in γS-crystallin causes autosomal dominant congenital nuclear cataract by increasing susceptibility to stresses. Int J Biol Macromol 2021, 172: 475-482. PMID: 33454329, DOI: 10.1016/j.ijbiomac.2021.01.079.Peer-Reviewed Original Research
2018
Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.
Yang X, Chen XJ, Yang Z, Xi YB, Wang L, Wu Y, Yan YB, Rao Y. Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation. J Med Chem 2018, 61: 8693-8706. PMID: 30153006, DOI: 10.1021/acs.jmedchem.8b00705.Peer-Reviewed Original ResearchThe cataract-causing mutation G75V promotes γS-crystallin aggregation by modifying and destabilizing the native structure.
Zhu S, Xi XB, Duan TL, Zhai Y, Li J, Yan YB, Yao K. The cataract-causing mutation G75V promotes γS-crystallin aggregation by modifying and destabilizing the native structure. Int J Biol Macromol 2018, 117: 807-814. PMID: 29857103, DOI: 10.1016/j.ijbiomac.2018.05.220.Peer-Reviewed Original Research
2016
Congenital microcornea-cataract syndrome-causing mutation X253R increases βB1-crystallin hydrophobicity to promote aggregate formation.
Leng XY, Li HY, Wang J, Qi LB, Xi YB, Yan YB. Congenital microcornea-cataract syndrome-causing mutation X253R increases βB1-crystallin hydrophobicity to promote aggregate formation. Biochem J 2016, 473: 2087-96. PMID: 27208166, DOI: 10.1042/BCJ20160247.Peer-Reviewed Original ResearchMembrane insertion of αA-crystallin is oligomer-size dependent.
Tjondro HC, Xi YB, Chen XJ, Su JT, Yan YB. Membrane insertion of αA-crystallin is oligomer-size dependent. Biochem Biophys Res Commun 2016, 473: 1-7. PMID: 26975472, DOI: 10.1016/j.bbrc.2016.03.033.Peer-Reviewed Original Research
2015
Corrigendum: Lanosterol reverses protein aggregation in cataracts.
Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, Hu LD, Ouyang H, Patel SH, Jin X, Lin D, Wu F, Flagg K, Cai H, Li G, Cao G, Lin Y, Chen D, Wen C, Chung C, Wang Y, Qiu A, Yeh E, Wang W, Hu X, Grob S, Abagyan R, Su Z, Tjondro HC, Zhao XJ, Luo H, Hou R, Perry JJ, Gao W, Kozak I, Granet D, Li Y, Sun X, Wang J, Zhang L, Liu Y, Yan YB, Zhang K. Corrigendum: Lanosterol reverses protein aggregation in cataracts. Nature 2015, 526: 595. PMID: 26308894, DOI: 10.1038/nature15253.Peer-Reviewed Original ResearchCongenital Cataract-Causing Mutation G129C in γC-Crystallin Promotes the Accumulation of Two Distinct Unfolding Intermediates That Form Highly Toxic Aggregates.
Xi YB, Chen XJ, Zhao WJ, Yan YB. Congenital Cataract-Causing Mutation G129C in γC-Crystallin Promotes the Accumulation of Two Distinct Unfolding Intermediates That Form Highly Toxic Aggregates. J Mol Biol 2015, 427: 2765-81. PMID: 26165230, DOI: 10.1016/j.jmb.2015.07.001.Peer-Reviewed Original ResearchLanosterol reverses protein aggregation in cataracts.
Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, Hu LD, Ouyang H, Patel SH, Jin X, Lin D, Wu F, Flagg K, Cai H, Li G, Cao G, Lin Y, Chen D, Wen C, Chung C, Wang Y, Qiu A, Yeh E, Wang W, Hu X, Grob S, Abagyan R, Su Z, Tjondro HC, Zhao XJ, Luo H, Hou R, Jefferson J, Perry P, Gao W, Kozak I, Granet D, Li Y, Sun X, Wang J, Zhang L, Liu Y, Yan YB, Zhang K. Lanosterol reverses protein aggregation in cataracts. Nature 2015, 523: 607-11. PMID: 26200341, DOI: 10.1038/nature14650.Peer-Reviewed Original Research
2014
Cataract-causing mutation R233H affects the stabilities of βB1- and βA3/βB1-crystallins with different pH-dependence.
Xi YB, Zhao WJ, Zuo XT, Tjondro HC, Li J, Dai AB, Wang S, Yan YB. Cataract-causing mutation R233H affects the stabilities of βB1- and βA3/βB1-crystallins with different pH-dependence. Biochim Biophys Acta 2014, 1842: 2216-29. PMID: 25086334, DOI: 10.1016/j.bbadis.2014.07.022.Peer-Reviewed Original ResearchCataract-linked mutation R188H promotes βB2-crystallin aggregation and fibrillization during acid denaturation.
Xi YB, Zhang K, Dai AB, Ji SR, Yao K, Yan YB. Cataract-linked mutation R188H promotes βB2-crystallin aggregation and fibrillization during acid denaturation. Biochem Biophys Res Commun 2014, 447: 244-9. PMID: 24704203, DOI: 10.1016/j.bbrc.2014.03.119.Peer-Reviewed Original Research
2012
A novel mutation impairing the tertiary structure and stability of γC-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens.
Li XQ, Cai HC, Zhou SY, Yang JH, Xi YB, Gao XB, Zhao WJ, Li P, Zhao GY, Tong Y, Bao FC, Ma Y, Wang S, Yan YB, Lu CL, Ma X. A novel mutation impairing the tertiary structure and stability of γC-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens. Hum Mutat 2012, 33: 391-401. PMID: 22052681, DOI: 10.1002/humu.21648.Peer-Reviewed Original ResearchThe congenital cataract-linked A2V mutation impairs tetramer formation and promotes aggregation of βB2-crystallin.
Xu J, Wang S, Zhao WJ, Xi YB, Yan YB, Yao K. The congenital cataract-linked A2V mutation impairs tetramer formation and promotes aggregation of βB2-crystallin. PLoS One 2012, 7: e51200. PMID: 23236454, DOI: 10.1371/journal.pone.0051200.Peer-Reviewed Original Research