2024
Type 2 innate immunity promotes the development of pulmonary fibrosis in Hermansky-Pudlak syndrome
Sorkhdini P, Klubock-Shukla K, Sheth S, Yang D, Yang A, Norbrun C, Introne W, Gochuico B, Zhou Y. Type 2 innate immunity promotes the development of pulmonary fibrosis in Hermansky-Pudlak syndrome. JCI Insight 2024, 9: e178381. PMID: 39405112, PMCID: PMC11601950, DOI: 10.1172/jci.insight.178381.Peer-Reviewed Original ResearchHermansky-Pudlak syndromeDevelopment of pulmonary fibrosisIdiopathic pulmonary fibrosisPulmonary fibrosisHermansky-Pudlak syndrome patientType 2 innate immunityOverexpression of CHI3L1Progressive pulmonary fibrosisPrimary lung fibroblastsFibrosis-related genesFibroproliferative repairILC2 accumulationILC2 populationSorted ILC2sLung ILC2sCo-culture experimentsILC2sFibrosis developmentFibrosisLung tissueHermansky-PudlakWild typeLung fibroblastsCo-cultureFibroproliferation
2023
Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomen
2021
Randomized trial of exercise on depressive symptomatology and brain derived neurotrophic factor (BDNF) in ovarian cancer survivors: The Women's Activity and Lifestyle Study in Connecticut (WALC)
Cartmel B, Hughes M, Ercolano EA, Gottlieb L, Li F, Zhou Y, Harrigan M, Ligibel JA, von Gruenigen VE, Gogoi R, Schwartz PE, Risch HA, Lu L, Irwin ML. Randomized trial of exercise on depressive symptomatology and brain derived neurotrophic factor (BDNF) in ovarian cancer survivors: The Women's Activity and Lifestyle Study in Connecticut (WALC). Gynecologic Oncology 2021, 161: 587-594. PMID: 33773809, PMCID: PMC8085084, DOI: 10.1016/j.ygyno.2021.02.036.Peer-Reviewed Original ResearchConceptsOvarian cancer survivorsCES-D scoresCancer survivorsOvarian cancerDepressive symptomatologyAC armStage III/IV ovarian cancerBaseline CES-D scoreTrial of exerciseEpidemiologic Studies Depression ScaleOvarian cancer patientsEffects of exerciseSix-month changesPrevalent mental disordersLower depressive symptomsExercise armSerum BrainNeurotrophin factorRandomized trialsNeurotrophic factorCancer patientsLifestyle StudyDepression ScalePhysical activityDepressive symptoms
2018
Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
Sanft T, Usiskin I, Harrigan M, Cartmel B, Lu L, Li FY, Zhou Y, Chagpar A, Ferrucci LM, Pusztai L, Irwin ML. Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study. Breast Cancer Research And Treatment 2018, 172: 105-112. PMID: 30062572, DOI: 10.1007/s10549-018-4895-7.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsWeight loss interventionUsual care groupBody mass indexBreast cancer riskCancer survivorsUsual careLoss interventionBreast cancerStage 0Quantitative polymerase chain reactionCare groupTelomere lengthCancer riskStage II/III breast cancerObese breast cancer survivorsWeight lossI breast cancerNon-Hispanic whitesPurposeSome studiesMass indexIntervention groupPhysical activityBlood samplesConclusionOur findingsLymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity
Iyer NS, Cartmel B, Friedman L, Li F, Zhou Y, Ercolano E, Harrigan M, Gottlieb L, McCorkle R, Schwartz PE, Irwin ML. Lymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity. Cancer 2018, 124: 1929-1937. PMID: 29437202, DOI: 10.1002/cncr.31239.Peer-Reviewed Original ResearchConceptsLower limb lymphedemaOvarian cancer survivorsCancer survivorsSelf-report questionnairesSide effectsSpecialist evaluationCancer treatmentDiagnostic methodsRandomized exercise interventionTrial of exerciseBody mass indexPhysical activity recommendationsEffects of exerciseOvarian cancer treatmentGynecologic cancer treatmentLymphedema prevalenceLymphedema specialistExercise groupExercise interventionDifferent diagnostic methodsMass indexBaseline prevalenceActivity recommendationsOvarian cancerLimb lymphedema
2017
Randomized Trial of Exercise on Quality of Life in Women With Ovarian Cancer: Women’s Activity and Lifestyle Study in Connecticut (WALC)
Zhou Y, Cartmel B, Gottlieb L, Ercolano EA, Li F, Harrigan M, McCorkle R, Ligibel JA, von Gruenigen VE, Gogoi R, Schwartz PE, Risch HA, Irwin ML. Randomized Trial of Exercise on Quality of Life in Women With Ovarian Cancer: Women’s Activity and Lifestyle Study in Connecticut (WALC). Journal Of The National Cancer Institute 2017, 109: djx072. PMID: 30053074, PMCID: PMC6515522, DOI: 10.1093/jnci/djx072.Peer-Reviewed Original ResearchConceptsCancer-related fatigueOvarian cancer survivorsOvarian cancerCancer survivorsExercise interventionPhysical HRQoLCommunity-based exercise programSix-month RCTHealth-related qualityPrimary care providersTreatment side effectsGroup differencesSix-month assessmentQuality of lifeExercise armOverall survivalHigher HRQoLExercise programMental HRQOLRandomized trialsLifestyle StudyControl armFatigue scoresHRQoLPhysical activity
2016
Randomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors
Thomas G, Cartmel B, Harrigan M, Fiellin M, Capozza S, Zhou Y, Ercolano E, Gross C, Hershman D, Ligibel J, Schmitz K, Li F, Sanft T, Irwin M. Randomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors. Medicine & Science In Sports & Exercise 2016, 48: 334. DOI: 10.1249/01.mss.0000486010.57056.60.Peer-Reviewed Original ResearchHealth-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors — I
Zhou Y, Irwin ML, Ferrucci LM, McCorkle R, Ercolano EA, Li F, Stein K, Cartmel B. Health-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors — I. Gynecologic Oncology 2016, 141: 543-549. PMID: 27072805, PMCID: PMC4913461, DOI: 10.1016/j.ygyno.2016.04.006.Peer-Reviewed Original ResearchConceptsOvarian cancer survivorsGreater symptom burdenAmerican Cancer Society's StudyHealth-related qualityCancer survivorsSymptom burdenDisease recurrencePhysical functioningTwo yearsOne-yearPredictors of HRQOLNumber of comorbiditiesHigher disease stagePhysical HRQoL scoresPoor mental functioningSubset of participantsMental health issuesMental functioningMore comorbiditiesHRQoL scoresClinical factorsLower HRQoLDisease stageHRQoL dataSecondary data analysisScientific Advances in Lung Cancer 2015
Tsao AS, Scagliotti GV, Bunn PA, Carbone DP, Warren GW, Bai C, de Koning HJ, Yousaf-Khan AU, McWilliams A, Tsao MS, Adusumilli PS, Rami-Porta R, Asamura H, Van Schil PE, Darling GE, Ramalingam SS, Gomez DR, Rosenzweig KE, Zimmermann S, Peters S, Ou S, Reungwetwattana T, Jänne PA, Mok TS, Wakelee HA, Pirker R, Mazières J, Brahmer JR, Zhou Y, Herbst RS, Papadimitrakopoulou VA, Redman MW, Wynes MW, Gandara DR, Kelly RJ, Hirsch FR, Pass HI. Scientific Advances in Lung Cancer 2015. Journal Of Thoracic Oncology 2016, 11: 613-638. PMID: 27013409, DOI: 10.1016/j.jtho.2016.03.012.Peer-Reviewed Original ResearchConceptsLung cancerMajor global health problemSpecific oncogenic driversLung cancer therapyGlobal health problemLung cancer researchOncogene-driven tumorsQuality of lifeImportant therapeutic breakthroughsAdvanced diseaseImmunotherapy fieldPrecision cancer medicineNew patientsNew agentsTherapeutic breakthroughHealth problemsOncogenic driversCancerTherapyCancer medicinePast yearSignificant scientific advancementsCancer 2015Cancer therapyRegulatory approvalExercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study
Arem H, Sorkin M, Cartmel B, Fiellin M, Capozza S, Harrigan M, Ercolano E, Zhou Y, Sanft T, Gross C, Schmitz K, Neogi T, Hershman D, Ligibel J, Irwin ML. Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study. Journal Of Cancer Survivorship 2016, 10: 654-662. PMID: 26782031, PMCID: PMC5418660, DOI: 10.1007/s11764-015-0511-6.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsCancer survivorsExercise adherenceAerobic exerciseCancer SurvivorsBreast cancer survivorsPostmenopausal breast cancer survivorsModerate-intensity aerobic exerciseAerobic exercise levelBetter exercise adherenceConclusionsBreast cancer survivorsLong exercise programSupervised exercise sessionsTrial of exerciseExercise training sessionsMin/weekPhysical exercise studiesPredictors of adherenceMaximal oxygen consumptionMonths postrandomizationJoint painExercise programExercise studiesCardiorespiratory fitnessExercise sessionsArthralgia
2015
Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study
Harrigan M, Cartmel B, Loftfield E, Sanft T, Chagpar AB, Zhou Y, Playdon M, Li F, Irwin ML. Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study. Journal Of Clinical Oncology 2015, 34: 669-676. PMID: 26598750, PMCID: PMC4872022, DOI: 10.1200/jco.2015.61.6375.Peer-Reviewed Original ResearchConceptsWeight loss counselingC-reactive protein levelsUsual careTelephone counselingPhysical activityBody compositionSerum biomarkersBreast cancerPerson counselingWeight loss intervention groupStage I breast cancerEffective weight loss strategyWeight lossI breast cancerBreast cancer survivorsBody mass indexBreast cancer mortalityWeight loss strategiesProtein levelsBreast cancer treatmentMean BMIUC groupMass indexCancer survivorsCancer mortalityLung Master Protocol (Lung-MAP)—A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400
Herbst RS, Gandara DR, Hirsch FR, Redman MW, LeBlanc M, Mack PC, Schwartz LH, Vokes E, Ramalingam SS, Bradley JD, Sparks D, Zhou Y, Miwa C, Miller VA, Yelensky R, Li Y, Allen JD, Sigal EV, Wholley D, Sigman CC, Blumenthal GM, Malik S, Kelloff GJ, Abrams JS, Blanke CD, Papadimitrakopoulou VA. Lung Master Protocol (Lung-MAP)—A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400. Clinical Cancer Research 2015, 21: 1514-1524. PMID: 25680375, PMCID: PMC4654466, DOI: 10.1158/1078-0432.ccr-13-3473.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaLung squamous cell carcinomaMaster protocolsClinical trialsAdvanced lung squamous cell carcinomaSquamous cell lung cancerCell lung cancerStandard of careMutation/amplificationTraditional clinical trialsDevelopment of therapiesInvestigational agentsCell carcinomaLung cancerCancer Genome Atlas (TCGA) projectMolecular abnormalitiesTherapyLungTrialsSignificant numberCarcinomaCancerAbnormalitiesProtocolCare
2014
Diet Quality and Survival After Ovarian Cancer: Results From the Women’s Health Initiative
Thomson CA, Crane T, Wertheim BC, Neuhouser ML, Li W, Snetselaar LG, Basen-Engquist KM, Zhou Y, Irwin ML. Diet Quality and Survival After Ovarian Cancer: Results From the Women’s Health Initiative. Journal Of The National Cancer Institute 2014, 106: dju314. PMID: 25335480, PMCID: PMC4271032, DOI: 10.1093/jnci/dju314.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAgedAged, 80 and overBody Mass IndexDiabetes ComplicationsFeeding BehaviorFemaleHumansMiddle AgedMotor ActivityNeoplasm StagingOdds RatioOvarian NeoplasmsPredictive Value of TestsProportional Hazards ModelsRisk FactorsSurveys and QuestionnairesUnited StatesWaist CircumferenceWomen's HealthConceptsOvarian cancer survivalPhysical activity levelsOvarian cancerWaist circumferenceDiet qualityCancer survivalWomen's Health Initiative Observational StudyHealth initiativesDietary qualityCox proportional hazards regressionModifiable lifestyle behaviorsHistory of diabetesFood frequency questionnaireOverall dietary qualityWomen's Health InitiativeProportional hazards regressionHealthy Eating IndexActivity levelsHigher diet qualityOvarian cancer diagnosisClinic-based measurementsCause mortalityPostmenopausal womenDiabetes statusFrequency questionnaireBody mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative
Zhou Y, Chlebowski R, LaMonte MJ, Bea JW, Qi L, Wallace R, Lavasani S, Walsh BW, Anderson G, Vitolins M, Sarto G, Irwin ML. Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative. Gynecologic Oncology 2014, 133: 4-10. PMID: 24680584, PMCID: PMC4064800, DOI: 10.1016/j.ygyno.2014.01.033.Peer-Reviewed Original ResearchConceptsWomen's Health InitiativeBody mass indexVigorous-intensity physical activityOvarian cancerPhysical activityHealth initiativesLower riskCause mortalityMass indexSelf-reported physical activityOvarian cancer mortalityModifiable lifestyle factorsProportional hazards regressionPrimary ovarian cancerOvarian cancer diagnosisPostmenopausal womenBaseline visitHazards regressionLifestyle factorsCancer mortalityMortality endpointsSurvival rateMortalityCancerCancer diagnosis
2010
Physical activity and endometrial cancer in a population-based case–control study
Arem H, Irwin ML, Zhou Y, Lu L, Risch H, Yu H. Physical activity and endometrial cancer in a population-based case–control study. Cancer Causes & Control 2010, 22: 219-226. PMID: 21110224, PMCID: PMC3075067, DOI: 10.1007/s10552-010-9689-0.Peer-Reviewed Original ResearchConceptsEndometrial cancer riskLower endometrial cancer riskMET h/wkPhysical activityCancer riskEndometrial cancerRisk factorsPopulation-based case-control studyInterview-administered questionnaireMetabolic equivalent hoursPhysical Activity QuestionnaireUnconditional logistic regressionRecreational physical activityCase-control studyAge-matched controlsPhysical activity dataIncident casesActivity QuestionnaireIndependent associationConclusionOur dataLifestyle informationBMILogistic regressionReference groupCancerPre- and post-diagnosis body mass index, weight change, and ovarian cancer mortality
Zhou Y, Irwin ML, Risch HA. Pre- and post-diagnosis body mass index, weight change, and ovarian cancer mortality. Gynecologic Oncology 2010, 120: 209-213. PMID: 21106231, PMCID: PMC3034401, DOI: 10.1016/j.ygyno.2010.10.035.Peer-Reviewed Original ResearchConceptsOvarian cancer mortalityCancer mortalityTime pointsWeight changeHigh riskPost-diagnosis body mass indexOvarian cancer-specific mortalityBMI 5 yearsCancer-specific mortalityInterview-administered questionnaireProportional hazards regressionBody mass indexEpithelial ovarian cancerCause mortalityHazards regressionMass indexSpecific mortalityOvarian cancerBMISurvival rateMortalityWeight gainDiagnosisStrong associationWomen