Featured Publications
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation
Arumugam S, Li B, Boodapati S, Nathanson M, Sun B, Ouyang X, Mehal W. Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation. Hepatology 2023, 78: 1448-1461. PMID: 37013923, PMCID: PMC10804318, DOI: 10.1097/hep.0000000000000388.Peer-Reviewed Original ResearchConceptsVoltage-dependent anion channelBioenergetic capacityMitochondrial DNATranscriptional upregulationCyclic GMP-AMP synthaseGMP-AMP synthaseTranscriptional regulationBioenergetic organellesFunctional mitochondriaMitochondrial membraneExternal mitochondrial membraneAnabolic pathwaysMitochondrial massAnion channelInterferon genesHSC transdifferentiationSubsequent activationCGAS-STINGTransdifferentiationIRF3 pathwayPathwaySTING pathwayGenesMitochondriaQuiescent HSCs
2009
IFN Regulatory Factor 8 Sensitizes Soft Tissue Sarcoma Cells to Death Receptor–Initiated Apoptosis via Repression of FLICE-like Protein Expression
Yang D, Wang S, Brooks C, Dong Z, Schoenlein PV, Kumar V, Ouyang X, Xiong H, Lahat G, Hayes-Jordan A, Lazar A, Pollock R, Lev D, Liu K. IFN Regulatory Factor 8 Sensitizes Soft Tissue Sarcoma Cells to Death Receptor–Initiated Apoptosis via Repression of FLICE-like Protein Expression. Cancer Research 2009, 69: 1080-1088. PMID: 19155307, PMCID: PMC2633427, DOI: 10.1158/0008-5472.can-08-2520.Peer-Reviewed Original ResearchAnimalsApoptosisCASP8 and FADD-Like Apoptosis Regulating ProteinCaspase 8Caspase InhibitorsCell Line, TumorEnzyme ActivationFas Ligand ProteinHumansImmunohistochemistryInterferon Regulatory FactorsMiceMitochondriaReceptors, TNF-Related Apoptosis-Inducing LigandRNA, MessengerRNA, Small InterferingSarcomaSarcoma, ExperimentalTNF-Related Apoptosis-Inducing Ligand