2022
Fermented Soy Drink (Q-CAN® PLUS) Induces Apoptosis and Reduces Viability of Cancer Cells
Ouyang X, Chen Y, Tejaswi BS, Arumugam S, Secor E, Weiss TR, Leapman M, Ali A. Fermented Soy Drink (Q-CAN® PLUS) Induces Apoptosis and Reduces Viability of Cancer Cells. Nutrition And Cancer 2022, 74: 3670-3678. PMID: 35603899, PMCID: PMC10986312, DOI: 10.1080/01635581.2022.2077385.Peer-Reviewed Original Research
2006
SOCS‐2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells
Ouyang X, Fujimoto M, Nakagawa R, Serada S, Tanaka T, Nomura S, Kawase I, Kishimoto T, Naka T. SOCS‐2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells. Journal Of Cellular Physiology 2006, 207: 428-436. PMID: 16419040, DOI: 10.1002/jcp.20579.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsBone Morphogenetic Protein 6Bone Morphogenetic ProteinsCell DifferentiationCell LineCell SurvivalChlorocebus aethiopsCOS CellsGene ExpressionLeupeptinsMiceMuscle Fibers, SkeletalMyoblastsMyoD ProteinMyogeninOsteoblastsOsteocalcinPhosphorylationProtein Kinase InhibitorsProto-Oncogene Proteins c-junSmad ProteinsSuppressor of Cytokine Signaling ProteinsTransfectionUp-RegulationConceptsC2C12 cellsJunB protein expressionSOCS-2Mesenchymal precursorsMyotube formationSmad-responsive reporter geneUbiquitin-proteasome pathwayCOS-7 cellsProtein expressionKey transcriptional factorBMP/SmadPrecursor cell lineSuppressor of cytokineGrowth hormone signalingSOCS familyCell fateHormone signalingTranscriptional activationBone morphogenic proteinAcceleration of proliferationTranscriptional levelReporter geneTranscriptional factorsNuclear accumulationJunB protein
2002
Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells
Takahashi K, Ouyang X, Komatsu K, Nakamura N, Hattori M, Baba A, Azuma J. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochemical Pharmacology 2002, 64: 745-750. PMID: 12167494, DOI: 10.1016/s0006-2952(02)01250-9.Peer-Reviewed Original ResearchConceptsSodium tanshinone IIA sulfonateAngiotensin IITanshinone IIA sulfonateEffect of STSCultured neonatal rat cardiac cellsCardiac cellsCultured cardiac cellsS. miltiorrhiza extractImmediate early gene expressionNeonatal rat heartsAttenuates hypertrophyCardiovascular diseaseC-jun expressionRat cardiac cellsDiphenylformazan assayRat heartTherapeutic basisCardiac fibroblastsNeonatal rat cardiac cellsEarly gene expressionCultured myocytesHypertrophyTanshinone IIAExact mechanismMyocytes
2001
Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells
Ouyang X, Takahashi K, Komatsu K, Nakamura N, Hattori M, Baba A, Azuma J. Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells. Journal Of Pharmacological Sciences 2001, 87: 289-296. PMID: 11829148, DOI: 10.1254/jjp.87.289.Peer-Reviewed Original ResearchConceptsCultured neonatal rat cardiac cellsAng IIRat cardiac cellsNeonatal rat cardiac cellsCardiac cellsHypertrophic responseSalvia miltiorrhizaImmediate early response gene expressionAng II actionAng II stimulationChronotropic responsivenessAngiotensin IIMorphological injuryDose-dependent cytotoxicityII stimulationProtective effectEarly response gene expressionDifferent pharmacological activitiesEthyl acetate insoluble fractionResponse gene expressionTanshinone IIAHypertrophic growthPharmacological activitiesCardiomyocytesEffective constituents