Amplitude of low-frequency fluctuations in bipolar disorder: A resting state fMRI study
Xu K, Liu H, Li H, Tang Y, Womer F, Jiang X, Chen K, Zhou Y, Jiang W, Luo X, Fan G, Wang F. Amplitude of low-frequency fluctuations in bipolar disorder: A resting state fMRI study. Journal Of Affective Disorders 2013, 152: 237-242. PMID: 24120087, DOI: 10.1016/j.jad.2013.09.017.Peer-Reviewed Original ResearchConceptsHealthy controlsBipolar disorderLow-frequency fluctuationsBD participantsPrefrontal cortexResting-state functional magnetic resonancePathophysiology of BDBaseline spontaneous activityNeural network abnormalitiesSpontaneous low-frequency fluctuationsBlood oxygenation level-dependent (BOLD) signalDorsal lateral prefrontal cortexState functional connectivityState fMRI studyRegional functional changesFrontal eye fieldRegional brain activityLevel-dependent signalTime of scanningVentral prefrontal cortexFunctional magnetic resonanceALFF methodALFF mapsBD groupBD pathophysiologySex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder
Kong L, Chen K, Womer F, Jiang W, Luo X, Driesen N, Liu J, Blumberg H, Tang Y, Xu K, Wang F. Sex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder. Journal Of Psychiatric Research 2013, 47: 733-739. PMID: 23453566, PMCID: PMC3626116, DOI: 10.1016/j.jpsychires.2013.02.003.Peer-Reviewed Original ResearchConceptsMajor depressive disorderHealthy controlsGray matter morphologyDepressive disorderPrefrontal cortexSex differencesHigh-resolution structural magnetic resonanceSignificant GM reductionsFemale healthy controlsLeft ventral prefrontal cortexStructural magnetic resonanceNeural systemsVentral prefrontal cortexClinical presentationLimbic regionsMedication-naïve participantsClinical aspectsRight hippocampusStriatal regionsBilateral caudateRight amygdalaHC groupGM reductionSex-related patternsMDD females