2024
Scaleable production of highly loaded protein nanoparticles for immune modulation
Caplan M, Baldwin R, Yin X, Grishin A, Eisenbarth S, Sampson H, Bottomly K, Prud’homme R. Scaleable production of highly loaded protein nanoparticles for immune modulation. Communications Materials 2024, 5: 191. DOI: 10.1038/s43246-024-00626-w.Peer-Reviewed Original ResearchAdjuvants to antigen-presenting cellsImmune modulationAntigen-presenting cellsMurine immune systemImmune system cellsPeanut-allergic patientsDesensitizer applicationPLG nanoparticlesAntigen deliverySystemic exposurePoly(lactide-co-glycolideBasophil activationClinical investigationAllergic responsesImmune systemSystem cellsProtein antigensClinical applicationDelivery of proteinsE. coli phospholipidsSafety evidenceAntigenProtein nanoparticlesDeliveryCells
2021
Dendritic Cell Regulation of T Helper Cells
Yin X, Chen S, Eisenbarth SC. Dendritic Cell Regulation of T Helper Cells. Annual Review Of Immunology 2021, 39: 1-32. PMID: 33710920, DOI: 10.1146/annurev-immunol-101819-025146.Peer-Reviewed Original ResearchConceptsDendritic cellsProfessional antigen-presenting cellsDendritic Cell RegulationDifferent DC subsetsT helper cellsAntigen-presenting cellsAdaptive immune responsesT lymphocyte differentiationTh cell differentiationDC subsetsRegulatory cellsDistinct CD4Follicular helperImmune toleranceSubset phenotypesImmune activationHelper cellsImmune cellsImmune responseImmune systemHeterogeneous subsetLymphocyte differentiationLocal tissue microenvironmentTissue microenvironmentCells