2023
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8
Zhang B, Chen S, Yin X, McBride C, Gertie J, Yurieva M, Bielecka A, Hoffmann B, Hinson J, Grassmann J, Xu L, Siniscalco E, Soldatenko A, Hoyt L, Joseph J, Norton E, Uthaman G, Palm N, Liu E, Eisenbarth S, Williams A. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8. Mucosal Immunology 2023, 17: 431-449. PMID: 38159726, PMCID: PMC11571232, DOI: 10.1016/j.mucimm.2023.12.001.Peer-Reviewed Original ResearchPlasma cellsLamina propriaT cell-dependent antigensCytokinesis 8 (DOCK8) mutationsDOCK8-deficient miceMucosal IgA productionRecurrent gastrointestinal infectionGut lamina propriaPoor antibody responseIgA class switchingAntigen-specific IgAEarly B cell activationLong-term survivalB cell activationGut IgAFood antigensAntibody responseIgA productionImmune homeostasisGastrointestinal infectionsPrimary immunodeficiencyT cellsPC compartmentB cellsCell activation
2019
IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection
Liu D, Yin X, Olyha SJ, Nascimento MSL, Chen P, White T, Gowthaman U, Zhang T, Gertie JA, Zhang B, Xu L, Yurieva M, Devine L, Williams A, Eisenbarth SC. IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection. Immunity 2019, 51: 64-76.e7. PMID: 31231033, PMCID: PMC6685086, DOI: 10.1016/j.immuni.2019.05.011.Peer-Reviewed Original ResearchConceptsListeria monocytogenes infectionB cellsMonocytogenes infectionInducible nitric oxide synthase (iNOS) expressionNitric oxide synthase expressionExchange factor DOCK8Conventional dendritic cellsOxide synthase expressionMarginal zone B cellsMarginal zoneMZ B cellsIntracellular ListeriaPrime CD8Dendritic cellsIL-10Cell primingInterleukin-10Listeria infectionSynthase expressionWhite pulpCell activationMetallophilic macrophagesBacterial infectionsCD8Infection