2022
SGLT2i Improves Glycemic Control in Patients With Congenital Severe Insulin Resistance.
Galderisi A, Tamborlane W, Taylor SI, Attia N, Moretti C, Barbetti F. SGLT2i Improves Glycemic Control in Patients With Congenital Severe Insulin Resistance. Pediatrics 2022, 150 PMID: 35652305, DOI: 10.1542/peds.2021-055671.Peer-Reviewed Original ResearchConceptsRabson-Mendenhall syndromeGlycemic controlHemoglobin A1cRenal calcium excretionInsulin-resistant diabetesSevere insulin resistanceCalcium excretionUrinary calciumAntidiabetic treatmentDay doseDose escalationSecond patientFirst patientInsulin levelsInsulin resistanceUrinary excretionSerum glucosePatientsEmpagliflozinMild increaseDapagliflozinΒ-hydroxybutyrateTarget rangeA1CExcretion
2014
The Artificial Pancreas: Are We There Yet?
Cefalu WT, Tamborlane WV. The Artificial Pancreas: Are We There Yet? Diabetes Care 2014, 37: 1182-1183. PMID: 24757224, PMCID: PMC5131852, DOI: 10.2337/dc14-0491.Peer-Reviewed Original ResearchReversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial
Savoye M, Caprio S, Dziura J, Camp A, Germain G, Summers C, Li F, Shaw M, Nowicka P, Kursawe R, DePourcq F, Kim G, Tamborlane WV. Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial. Diabetes Care 2014, 37: 317-324. PMID: 24062325, PMCID: PMC3898759, DOI: 10.2337/dc13-1571.Peer-Reviewed Original ResearchConceptsStandard of careClinical careBlood glucoseObese adolescentsObese youthOral glucose tolerance test glucoseIntensive lifestyle modificationDiabetes Prevention ProgramStandard clinical careInsulin sensitivity indexHealthy lifestyle programType 2 diabetesRisk of T2DChildhood obesity epidemicΒ-cell dysfunctionLifestyle modificationControlled TrialsOGTT glucosePrimary outcomeGlucose toleranceInsulin resistanceLifestyle programAnthropometric assessmentEarly abnormalitiesGlucose levels
2008
Short‐term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance
Burgert TS, Duran EJ, Goldberg‐Gell R, Dziura J, Yeckel CW, Katz S, Tamborlane WV, Caprio S. Short‐term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance. Pediatric Diabetes 2008, 9: 567-576. PMID: 18761646, DOI: 10.1111/j.1399-5448.2008.00434.x.Peer-Reviewed Original ResearchConceptsNormal glucose toleranceInsulin sensitivityGlucose toleranceObese childrenDouble-blind clinical trialType 2 diabetes mellitusSubcutaneous fatCardio-metabolic consequencesBaseline insulin sensitivityImproved insulin sensitivityInsulin-resistant adolescentsHeart rate recoveryLong-term treatmentDeep subcutaneous fatShort-term useMagnetic resonance imagingPlacebo groupCardiovascular effectsDiabetes mellitusMetS groupClinical effectsLipid parametersInsulin sensitizersInflammatory cytokinesObese adolescents
2007
Effects of a Weight Management Program on Body Composition and Metabolic Parameters in Overweight Children: A Randomized Controlled Trial
Savoye M, Shaw M, Dziura J, Tamborlane WV, Rose P, Guandalini C, Goldberg-Gell R, Burgert TS, Cali AM, Weiss R, Caprio S. Effects of a Weight Management Program on Body Composition and Metabolic Parameters in Overweight Children: A Randomized Controlled Trial. JAMA 2007, 297: 2697-2704. PMID: 17595270, DOI: 10.1001/jama.297.24.2697.Peer-Reviewed Original ResearchConceptsWeight management programWeight management groupOverweight childrenMetabolic complicationsInsulin resistanceBody fatBody compositionControl groupArray of comorbiditiesMost overweight childrenSix-month improvementsHomeostasis model assessmentPediatric obesity clinicSerious metabolic complicationWeight management counselingType 2 diabetesMajor health issueFamily-based programsMixed ethnic groupsMonths of studyHOMA-IRObesity clinicOverweight adultsControlled TrialsPediatric obesity
2006
Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat
Burgert TS, Taksali SE, Dziura J, Goodman TR, Yeckel CW, Papademetris X, Constable RT, Weiss R, Tamborlane WV, Savoye M, Seyal AA, Caprio S. Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4287-4294. PMID: 16912127, DOI: 10.1210/jc.2006-1010.Peer-Reviewed Original ResearchConceptsIntrahepatic fat accumulationAlanine aminotransferase levelsHepatic fat fractionVisceral fatInsulin sensitivityMagnetic resonance imagingFat accumulationAminotransferase levelsMetabolic syndromeFatty liverInsulin resistanceChildhood obesityResonance imagingLipid metabolismNonalcoholic fatty liver diseaseHispanic race/ethnicityAbdominal fat partitioningSerum aminotransferase elevationFatty liver diseaseBiomarkers of inflammationHepatic fat accumulationReduced insulin sensitivityFat fractionRace/ethnicityAminotransferase elevationFulfilling the promise of insulin pump therapy in childhood diabetes
Tamborlane WV. Fulfilling the promise of insulin pump therapy in childhood diabetes. Pediatric Diabetes 2006, 7: 4-10. PMID: 16774611, DOI: 10.1111/j.1399-543x.2006.00171.x.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoring systemContinuous subcutaneous insulin infusion (CSII) treatmentType 1 diabetes mellitusRapid-acting insulin analoguesTreatment of T1DMComplications TrialDiabetes mellitusDiabetes controlGlucose monitoring systemChildhood diabetesFavorable outcomeInsulin analoguesInfusion treatmentInsulin pumpTherapyMinimal riskT1DMDiabetesInsulinTreatmentMellitusHypoglycemiaCSIIRecent introductionEthnic differences in beta cell adaptation to insulin resistance in obese children and adolescents
Weiss R, Dziura JD, Burgert TS, Taksali SE, Tamborlane WV, Caprio S. Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents. Diabetologia 2006, 49: 571-579. PMID: 16456682, DOI: 10.1007/s00125-005-0109-z.Peer-Reviewed Original ResearchConceptsEarly insulin responseObese childrenInsulin resistanceInsulin clearanceInsulin responseAims/hypothesisThe prevalenceObesity-related insulin resistanceOral glucose loadLower insulin clearanceType 2 diabetesAcute insulin responseGlucose tolerance levelsAltered glucose metabolismSevere insulin resistanceBeta-cell adaptationAfrican American subjectsEthnic groupsHypothesisThe prevalenceGlucose toleranceGlucose loadInsulin sensitivityGlucose metabolismMethodsSeven hundredClearanceHispanic origin
2005
Microalbuminuria in pediatric obesity: prevalence and relation to other cardiovascular risk factors
Burgert TS, Dziura J, Yeckel C, Taksali SE, Weiss R, Tamborlane W, Caprio S. Microalbuminuria in pediatric obesity: prevalence and relation to other cardiovascular risk factors. International Journal Of Obesity 2005, 30: 273-280. PMID: 16231019, DOI: 10.1038/sj.ijo.0803136.Peer-Reviewed Original ResearchConceptsUrine albumin-creatinine ratioPresence of microalbuminuriaBody mass indexCV riskBlood pressureMetabolic syndromeRisk factorsIndividual CV risk factorsRelationship of microalbuminuriaAlbumin-creatinine ratioCardiovascular risk factorsCV risk factorsOral glucose toleranceInsulin sensitivity indexRisk factor constellationsEarly vasculopathyMicroalbuminuric rangeCardiovascular eventsCV diseaseGross proteinuriaInflammatory markersEndothelial dysfunctionNondiabetic adultsObesity clinicCreatinine ratioβ-Cell Function Across the Spectrum of Glucose Tolerance in Obese Youth
Weiss R, Caprio S, Trombetta M, Taksali SE, Tamborlane WV, Bonadonna R. β-Cell Function Across the Spectrum of Glucose Tolerance in Obese Youth. Diabetes 2005, 54: 1735-1743. PMID: 15919795, DOI: 10.2337/diabetes.54.6.1735.Peer-Reviewed Original ResearchDisease Management in the Young Diabetic Patient: Glucose Monitoring, Coping Skills, and Treatment Strategies
Weinzimer SA, Doyle EA, Tamborlane WV. Disease Management in the Young Diabetic Patient: Glucose Monitoring, Coping Skills, and Treatment Strategies. Clinical Pediatrics 2005, 44: 393-403. PMID: 15965545, DOI: 10.1177/000992280504400503.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdolescent BehaviorAdultAge FactorsAgedAttitude to HealthBlood GlucoseBlood Glucose Self-MonitoringChildDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansHypoglycemic AgentsInjections, SubcutaneousInsulinInsulin ResistanceMaleMiddle AgedPatient CompliancePatient Education as TopicPrognosisRisk AssessmentSeverity of Illness IndexTreatment OutcomeConceptsYoung diabetic patientsGlycemic controlDiabetic patientsType 1 diabetes mellitusContinuous subcutaneous insulin infusionPresence of hypoglycemiaSubcutaneous insulin infusionType 2 diabetesDisease managementContinuous glucose-monitoring systemPositive treatment outcomesGlucose-monitoring systemInsulin glargineYounger patientsDiabetes mellitusHypoglycemic episodesJuvenile patientsNocturnal hypoglycemiaInsulin infusionTreatment outcomesTreatment strategiesCareful monitoringDiabetesPatientsGlucose monitoringThe “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning
Weiss R, Taksali SE, Dufour S, Yeckel CW, Papademetris X, Cline G, Tamborlane WV, Dziura J, Shulman GI, Caprio S. The “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 3731-3737. PMID: 15797955, DOI: 10.1210/jc.2004-2305.Peer-Reviewed Original ResearchConceptsInsulin sensitivityVisceral fatLipid depositionObese insulin-resistant adolescentsObese insulin-sensitive subjectsNormal glucose tolerancePeripheral insulin sensitivityIntramyocellular lipid contentBody mass indexInsulin-sensitive subjectsHyperinsulinemic-euglycemic clampInsulin-resistant adolescentsInsulin-sensitive controlsWide interindividual variationLipid partitioningLower lipid depositionPercent body fatMagnetic resonance imagingImportance of adiponectinObese insulinObese groupGlucose toleranceMass indexObese adolescentsIntramyocellular lipids
2004
The Normal Glucose Tolerance Continuum in Obese Youth: Evidence for Impairment in β-Cell Function Independent of Insulin Resistance
Yeckel CW, Taksali SE, Dziura J, Weiss R, Burgert TS, Sherwin RS, Tamborlane WV, Caprio S. The Normal Glucose Tolerance Continuum in Obese Youth: Evidence for Impairment in β-Cell Function Independent of Insulin Resistance. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 747-754. PMID: 15522932, DOI: 10.1210/jc.2004-1258.Peer-Reviewed Original ResearchConceptsBeta-cell responsivenessNormal glucose tolerancePlasma glucose levelsGlucose levelsGlucose toleranceInsulin sensitivityPlasma glucoseObese youthOral glucose tolerance testType 2 diabetes mellitusDecreased insulinogenic indexGlucose tolerance continuumGlucose tolerance testInsulin sensitivity indexContinuum of riskDelta insulinInsulinogenic indexDiabetes mellitusInsulin resistancePlasma levelsTolerance testNormal rangeFunction IndependentDlGlucose concentrationObesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. New England Journal Of Medicine 2004, 350: 2362-2374. PMID: 15175438, DOI: 10.1056/nejmoa031049.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdolescentAdultChildChild, PreschoolC-Reactive ProteinFemaleFollow-Up StudiesGlucose Tolerance TestHumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsInterleukin-6Logistic ModelsMaleMetabolic SyndromeObesityPrevalenceProteinsRisk FactorsSeverity of Illness IndexConceptsDegree of obesityC-reactive proteinMetabolic syndromeBody mass indexAdiponectin levelsInsulin resistanceBlood pressureStandard glucose tolerance testC-reactive protein levelsHigh-density lipoprotein cholesterolZ-scoreAdverse cardiovascular outcomesSeverity of obesityGlucose tolerance testLevels of triglyceridesCardiovascular outcomesLipoprotein cholesterolObese subjectsObese childrenUnit of increaseMultiracial cohortNonobese childrenPlasma lipidsChildhood obesityObesityValidation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S. Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 1096-1101. PMID: 15001593, DOI: 10.1210/jc.2003-031503.Peer-Reviewed Original ResearchConceptsWhole-body insulin sensitivity indexOral glucose tolerance testInsulin sensitivity indexIntramyocellular lipid contentInsulin sensitivityInsulin resistanceObese youthLarge cohortComposite whole body insulin sensitivity indexOral glucose tolerance test parametersSurrogate indexClamp-derived insulin sensitivityImpaired glucose toleranceGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampInsulin sensitivity measurementsGlucose toleranceMetabolic syndromeObese childrenObese populationPoor functionPlasma glucoseTolerance testInsulin response
2003
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
Weiss R, Dufour S, Taksali SE, Tamborlane WV, Petersen KF, Bonadonna RC, Boselli L, Barbetta G, Allen K, Rife F, Savoye M, Dziura J, Sherwin R, Shulman GI, Caprio S. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. The Lancet 2003, 362: 951-957. PMID: 14511928, PMCID: PMC2995523, DOI: 10.1016/s0140-6736(03)14364-4.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAdipose TissueAdolescentChildFemaleGlucose Tolerance TestHumansInsulinInsulin ResistanceMaleMuscle, SkeletalObesityPrediabetic StateConceptsImpaired glucose toleranceNormal glucose toleranceGlucose toleranceObese childrenInsulin resistanceObese adolescentsGlucose disposalInsulin sensitivitySevere peripheral insulin resistanceNon-oxidative glucose metabolismSubcutaneous fatH plasma glucose concentrationsAbdominal fat partitioningVisceral lipid contentsPeripheral glucose disposalHigher intramyocellular lipid contentAbdominal fat distributionDegree of obesityIntramyocellular lipid contentPeripheral insulin resistanceHigh visceral fatAbdominal subcutaneous fatEuglycaemic hyperinsulinaemic clampSevere insulin resistancePlasma glucose concentration
1996
Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children
Caprio S, Bronson M, Sherwin RS, Rife F, Tamborlane WV. Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children. Diabetologia 1996, 39: 1489-1497. PMID: 8960831, DOI: 10.1007/s001250050603.Peer-Reviewed Original ResearchConceptsObese groupHyperglycaemic clampInsulin resistanceObese preadolescentsInsulin actionGlucose-stimulated insulin levelsHigher insulin infusion ratesNon-oxidative glucose metabolismGlucose uptakeDuration of obesityGroup of obeseNon-obese subjectsBeta-cell functionDevelopment of obesityEuglycaemic hyperinsulinaemic clampSevere insulin resistanceInsulin infusion rateCross-sectional analysisOnset of pubertyAbility of insulinSevere obesityObese adultsObese childrenObese subjectsInsulin levels
1995
Central adiposity and its metabolic correlates in obese adolescent girls
Caprio S, Hyman LD, Limb C, McCarthy S, Lange R, Sherwin RS, Shulman G, Tamborlane WV. Central adiposity and its metabolic correlates in obese adolescent girls. American Journal Of Physiology 1995, 269: e118-e126. PMID: 7631766, DOI: 10.1152/ajpendo.1995.269.1.e118.Peer-Reviewed Original ResearchConceptsObese adolescent girlsObese girlsInsulin secretionInsulin actionSubcutaneous abdominal fat depotsFree fatty acid levelsGlucose-stimulated insulin responseHip circumference ratioEuglycemic insulin clampHyperglycemic clamp techniqueBasal insulin secretionAbdominal fat depotsAdolescent girlsHepatic glucose productionFatty acid levelsMagnetic resonance imagingLean womenCentral adiposityInsulin dosesVisceral fatInsulin clampInsulin resistanceNonobese girlsGlucose disposalInsulin infusion
1991
Insulin Resistance: An Early Metabolic Defect of Turner's Syndrome*
CAPRIO S, BOULWARE S, DIAMOND M, SHERWIN R, CARPENTER TO, RUBIN K, AMIEL S, PRESS M, TAMBORLANE W. Insulin Resistance: An Early Metabolic Defect of Turner's Syndrome*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 832-836. PMID: 2005209, DOI: 10.1210/jcem-72-4-832.Peer-Reviewed Original ResearchConceptsInsulin-stimulated glucose metabolismEarly metabolic defectsNormal controlsGlucose metabolismTurner syndromeEuglycemic clampInsulin resistanceGroup 2Metabolic defectsTurner patientsAge-matched normal controlsChain amino acid levelsGroup of patientsRisk of diabetesNonoxidative glucose disposalIntracellular glucose metabolismWhole-body glucoseHepatic glucose productionNondiabetic patientsEstrogen therapyHormone therapyYounger patientsGlucose disposalHepatic sensitivityInsulin sensitivityInsulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*
AMIEL S, CAPRIO S, SHERWIN R, PLEWE G, HAYMOND M, TAMBORLANE W. Insulin Resistance of Puberty: a Defect Restricted to Peripheral Glucose Metabolism*. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 277-282. PMID: 1991798, DOI: 10.1210/jcem-72-2-277.Peer-Reviewed Original ResearchConceptsPeripheral glucose metabolismInsulin resistancePubertal childrenGlucose metabolismHigher insulin doseMU/m2Hyperglycemic clamp studiesEuglycemic insulin clampEnhanced insulin responseHepatic glucose productionSelective insulin resistanceChain amino acidsHealthy prepubertalCompensatory hyperinsulinemiaInsulin doseInsulin clampPeripheral glucoseInsulin responsePlasma levelsPrepubertal childrenClamp studiesProtein anabolismNormal pubertyGlucose productionAmino acid metabolism