2022
Long-term Continuous Glucose Monitor Use in Very Young Children With Type 1 Diabetes: One-Year Results From the SENCE Study
Van Name MA, Kanapka LG, DiMeglio LA, Miller KM, Albanese-O’Neill A, Commissariat P, Corathers SD, Harrington KR, Hilliard ME, Anderson BJ, Kelley JC, Laffel LM, MacLeish SA, Nathan BM, Tamborlane WV, Wadwa RP, Willi SM, Williams KM, Wintergerst KA, Woerner S, Wong JC, DeSalvo DJ. Long-term Continuous Glucose Monitor Use in Very Young Children With Type 1 Diabetes: One-Year Results From the SENCE Study. Journal Of Diabetes Science And Technology 2022, 17: 976-987. PMID: 35343269, PMCID: PMC10348002, DOI: 10.1177/19322968221084667.Peer-Reviewed Original ResearchConceptsFamily behavioral interventionsContinuous glucose monitoringBlood glucose monitoringCGM useYoung childrenGlucose monitoringOne-year resultsType 1 diabetesContinuous glucose monitor useHemoglobin A1cCGM groupGlycemic outcomesType 1Behavioral interventionsExtension phaseBGM groupMonitor useOne-year studyCGM technologyDiabetes technologyGlycemiaHypoglycemiaChildrenBehavioural supportGroupContinuous Glucose Monitoring in Adults With Type 1 Diabetes With 35 Years Duration From the DCCT/EDIC Study.
Gubitosi-Klug RA, Braffett BH, Bebu I, Johnson ML, Farrell K, Kenny D, Trapani VR, Meadema-Mayer L, Soliman EZ, Pop-Busui R, Lachin JM, Bergenstal RM, Tamborlane WV. Continuous Glucose Monitoring in Adults With Type 1 Diabetes With 35 Years Duration From the DCCT/EDIC Study. Diabetes Care 2022, 45: 659-665. PMID: 35076697, PMCID: PMC8918229, DOI: 10.2337/dc21-0629.Peer-Reviewed Original ResearchConceptsType 1 diabetesContinuous glucose monitoringInsulin pumpDCCT/EDIC studyComplications Trial/EpidemiologyGlucose monitoringPercent timeRelevant clinical goalsYears of ageMean sensor glucoseSubset of adultsComplications StudyEDIC studyEntire recording periodOlder patientsGlycemic excursionsDiabetes controlSignificant hypoglycemiaDiabetes InterventionsYears durationHypoglycemiaSensor glucoseClinical goalsHyperglycemic excursionsType 1
2021
Withdrawn as duplicate: Corrigendum to: Continuous Glucose Monitoring: An Endocrine Society Clinical Practice Guideline
Klonoff DC, Buckingham B, Christiansen JS, Montori VM, Tamborlane WV, Vigersky RA, Wolpert H. Withdrawn as duplicate: Corrigendum to: Continuous Glucose Monitoring: An Endocrine Society Clinical Practice Guideline. The Journal Of Clinical Endocrinology & Metabolism 2021, 107: e2220-e2220. PMID: 34878114, DOI: 10.1210/clinem/dgab251.Peer-Reviewed Original ResearchEndocrine Society Clinical Practice GuidelineClinical practice guidelinesContinuous glucose monitoringPractice guidelinesGlucose monitoringImpact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study.
Mauras N, Buckingham B, White NH, Tsalikian E, Weinzimer SA, Jo B, Cato A, Fox LA, Aye T, Arbelaez AM, Hershey T, Tansey M, Tamborlane W, Foland-Ross LC, Shen H, Englert K, Mazaika P, Marzelli M, Reiss AL. Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study. Diabetes Care 2021, 44: 983-992. PMID: 33568403, PMCID: PMC7985430, DOI: 10.2337/dc20-2125.Peer-Reviewed Original ResearchConceptsType 1 diabetesBrain volumeControl subjectsTotal brain volume differencesEarly-onset type 1 diabetesAge-matched control subjectsIntelligence quotientCognitive scoresWhite matter volumeBrain volume differencesContinuous glucose monitoringDiabetes groupFull-scale intelligence quotientDiabetes complicationsDiabetes controlTotal brainVerbal intelligence quotientDiabetesMatter volumeSensor glucoseCognitive testingGlucose monitoringMixed-effects modelsBrainGroup differences
2019
Greater parental comfort with lower glucose targets in young children with Type 1 diabetes using continuous glucose monitoring
Van Name MA, Miller KM, Commissariat PV, Whitehouse AL, Harrington KR, Anderson BJ, Mantravadi MG, Levy W, DeSalvo DJ, Tamborlane WV, Hilliard ME, Laffel LM, DiMeglio LA. Greater parental comfort with lower glucose targets in young children with Type 1 diabetes using continuous glucose monitoring. Diabetic Medicine 2019, 36: 1508-1510. PMID: 31295359, PMCID: PMC7027357, DOI: 10.1111/dme.14074.Peer-Reviewed Original ResearchConceptsType 1 diabetesContinuous glucose monitoringGlucose targetsParental comfortGlucose monitoringYoung childrenBenefits and Barriers of Continuous Glucose Monitoring in Young Children with Type 1 Diabetes
Hilliard ME, Levy W, Anderson BJ, Whitehouse AL, Commissariat PV, Harrington KR, Laffel LM, Miller KM, Van Name M, Tamborlane WV, DeSalvo DJ, DiMeglio LA. Benefits and Barriers of Continuous Glucose Monitoring in Young Children with Type 1 Diabetes. Diabetes Technology & Therapeutics 2019, 21: 493-498. PMID: 31287721, PMCID: PMC6708264, DOI: 10.1089/dia.2019.0142.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoringCGM useDiabetes managementDiabetes careBenefits of CGMYoung childrenGlucose monitoringMean child ageChildren's diabetes careType 1 diabetes managementPainful insertionT1D durationParents of childrenGlucose excursionsImproved sleepClinical strategiesSemistructured qualitative interviewsType 1Parental comfortChild's ageChildrenBehavioural supportMultiple barriersParents' experiencesCaregiversContinuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study
Shah VN, DuBose SN, Li Z, Beck RW, Peters AL, Weinstock RS, Kruger D, Tansey M, Sparling D, Woerner S, Vendrame F, Bergenstal R, Tamborlane WV, Watson SE, Sherr J. Continuous Glucose Monitoring Profiles in Healthy Nondiabetic Participants: A Multicenter Prospective Study. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 4356-4364. PMID: 31127824, PMCID: PMC7296129, DOI: 10.1210/jc.2018-02763.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoringMedian timeAge groupsProspective studyNondiabetic individualsGlucose levelsAverage glucoseNonobese body mass indexT1D Exchange Clinic NetworkContinuous glucose monitoring (CGM) profilesInsulin-requiring patientsMulticenter prospective studyBody mass indexDifferent age groupsNondiabetic childrenNondiabetic populationGlycemic profileMass indexNondiabetic participantsGlycemic variabilityMean glucoseClinic networkCGM metricsGlycemic metricsGlucose monitoringState of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018
Foster NC, Beck RW, Miller KM, Clements MA, Rickels MR, DiMeglio LA, Maahs DM, Tamborlane WV, Bergenstal R, Smith E, Olson BA, Garg SK. State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018. Diabetes Technology & Therapeutics 2019, 21: 66-72. PMID: 30657336, PMCID: PMC7061293, DOI: 10.1089/dia.2018.0384.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoringT1D Exchange RegistryRegistry participantsDiabetes managementHigher mean HbA1cType 1 diabetesType 1 diabetes managementMinority of adultsProfile of adultsHbA1c goalDiabetic ketoacidosisMean HbA1cSevere hypoglycemiaClinical outcomesT1D ExchangeT1D managementAge 30Longitudinal changesADA goalsAge 28Age 15Glucose monitoringYoung adultsCGM usersRacial differences
2017
Continuous Glucose Monitoring in Very Preterm Infants: A Randomized Controlled Trial
Galderisi A, Facchinetti A, Steil GM, Ortiz-Rubio P, Cavallin F, Tamborlane WV, Baraldi E, Cobelli C, Trevisanuto D. Continuous Glucose Monitoring in Very Preterm Infants: A Randomized Controlled Trial. Pediatrics 2017, 140: e20171162. PMID: 28916591, DOI: 10.1542/peds.2017-1162.Peer-Reviewed Original ResearchConceptsVery preterm infantsGlucose infusion rateContinuous glucose monitoringPreterm infantsCGM groupPercentage of timeEuglycemic rangeSevere hyperglycemiaSevere hypoglycemiaGlycemic variabilityGlucose monitoringCare blood glucose monitoringUse of CGMPoor neurologic outcomeImpaired glucose controlBlood glucose monitoringBlood glucose determinationNeurologic outcomeSecondary outcomesInsulin titrationPrimary outcomeWeeks' gestationControlled TrialsGlucose controlBirth weightPostprandial Dosing of Bolus Insulin in Patients with type 1 Diabetes: a Cross-sectional Study Using Data From the T1d Exchange Registry
Peters A, Van Name MA, Thorsted B, Piltoft JS, Tamborlane WV. Postprandial Dosing of Bolus Insulin in Patients with type 1 Diabetes: a Cross-sectional Study Using Data From the T1d Exchange Registry. Endocrine Practice 2017, 23: 1201-1209. PMID: 28704103, DOI: 10.4158/ep171813.or.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood GlucoseBlood Glucose Self-MonitoringChildChild, PreschoolCross-Sectional StudiesDiabetes Mellitus, Type 1Diabetic KetoacidosisDrug Dosage CalculationsFemaleHumansHypoglycemiaInfantInsulinInsulin Infusion SystemsMaleMiddle AgedPostprandial PeriodRegistriesYoung AdultConceptsRapid-acting insulin analoguesLarger insulin doseT1D Exchange RegistryType 1 diabetesCross-sectional studyDiabetic ketoacidosisInsulin doseGreater prevalenceCurrent rapid-acting insulin analoguesInsulin analoguesSelf-monitoring blood glucosePercent of patientsCharacteristics of patientsPoor glycemic controlExclusion of patientsBody mass indexContinuous glucose monitoringPostprandial dosingGlycemic controlSevere hypoglycemiaBolus insulinMass indexEnrollment questionnaireBlood glucoseGlucose levelsInsulin Pump Use in Young Children with Type 1 Diabetes: Sociodemographic Factors and Parent-Reported Barriers
Commissariat PV, Boyle CT, Miller KM, Mantravadi MG, DeSalvo DJ, Tamborlane WV, Van Name MA, Anderson BJ, DiMeglio LA, Laffel LM. Insulin Pump Use in Young Children with Type 1 Diabetes: Sociodemographic Factors and Parent-Reported Barriers. Diabetes Technology & Therapeutics 2017, 19: 363-369. PMID: 28581817, PMCID: PMC6435342, DOI: 10.1089/dia.2016.0375.Peer-Reviewed Original ResearchMeSH KeywordsBlood GlucoseBlood Glucose Self-MonitoringChildChild, PreschoolCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 1FemaleGlycated HemoglobinHealth Care SurveysHumansHypoglycemic AgentsInsulinInsulin Infusion SystemsMaleMonitoring, AmbulatoryParentsPatient Acceptance of Health CarePatient PreferenceRegistriesSocioeconomic FactorsUnited StatesConceptsBlood glucose monitoringContinuous glucose monitoringGlycemic controlGlucose monitoringMore frequent blood glucose monitoringPump usersYoung childrenFrequent blood glucose monitoringParent-reported reasonsDuration of diabetesOverall glycemic controlInsulin pump useT1D Exchange RegistryParent-reported barriersType 1 diabetesAnnual household incomeClinical characteristicsT1D durationParents of childrenPump therapyCGM usePump useSociodemographic factorsTherapeutic effectivenessType 1Schooling diabetes: Use of continuous glucose monitoring and remote monitors in the home and school settings
Erie C, Van Name MA, Weyman K, Weinzimer SA, Finnegan J, Sikes K, Tamborlane WV, Sherr JL. Schooling diabetes: Use of continuous glucose monitoring and remote monitors in the home and school settings. Pediatric Diabetes 2017, 19: 92-97. PMID: 28303678, PMCID: PMC5601025, DOI: 10.1111/pedi.12518.Peer-Reviewed Original ResearchGlucose Outcomes with the In-Home Use of a Hybrid Closed-Loop Insulin Delivery System in Adolescents and Adults with Type 1 Diabetes
Garg SK, Weinzimer SA, Tamborlane WV, Buckingham BA, Bode BW, Bailey TS, Brazg RL, Ilany J, Slover RH, Anderson SM, Bergenstal RM, Grosman B, Roy A, Cordero TL, Shin J, Lee SW, Kaufman FR. Glucose Outcomes with the In-Home Use of a Hybrid Closed-Loop Insulin Delivery System in Adolescents and Adults with Type 1 Diabetes. Diabetes Technology & Therapeutics 2017, 19: 155-163. PMID: 28134564, PMCID: PMC5359676, DOI: 10.1089/dia.2016.0421.Peer-Reviewed Original ResearchConceptsHybrid closed-loop insulin delivery systemGlucose valuesDiabetic ketoacidosis eventsMulticenter pivotal trialStudy phaseBlood sample testingType 1 diabetesClosed-loop insulin delivery systemBlood glucose valuesHome useContinuous glucose monitoringSensor glucose valuesHCl therapyKetoacidosis eventsHybrid closed-loop systemPivotal trialsInsulin delivery systemsGlucose outcomesMedtronic MiniMedType 1Glucose monitoringInsulin deliveryAdultsStayAdolescents
2016
Continuous Glucose Monitoring: A Consensus Conference of the American Association of Clinical Endocrinologists and American College of Endocrinology
Fonseca VA, Grunberger G, Anhalt H, Bailey TS, Blevins T, Garg SK, Handelsman Y, Hirsch IB, Orzeck EA, Roberts VL, Tamborlane W, Committee O. Continuous Glucose Monitoring: A Consensus Conference of the American Association of Clinical Endocrinologists and American College of Endocrinology. Endocrine Practice 2016, 22: 1008-1021. PMID: 27214060, DOI: 10.4158/ep161392.cs.Peer-Reviewed Original ResearchConceptsContinuous glucose monitoringAmerican CollegeCGM coverageClinical EndocrinologistsBenefits of CGMSensor-Augmented Pump TherapyClinical Endocrinologists ACEHealthcare resource utilizationIntensive insulin therapyHealth-related qualityType 1 diabetesManagement of diabetesAmerican AssociationAvailable CGM dataReal-world analysisChronic complicationsInsulin therapyDiabetes typeGlycemic controlPump therapyPatient understandingConsensus conferenceDiabetes managementHealth outcomesType 2Characteristics of youth with type 1 diabetes (T1D) with and without a parent with T1D in the T1D exchange clinic registry
Fox LA, Mubasher M, Wolfsdorf JI, Buckingham BA, Peters AL, Tamborlane WV, Schatz DA, Maahs DM, Miller KM, Beck RW, Network F. Characteristics of youth with type 1 diabetes (T1D) with and without a parent with T1D in the T1D exchange clinic registry. Journal Of Diabetes 2016, 8: 834-838. PMID: 26663683, DOI: 10.1111/1753-0407.12363.Peer-Reviewed Original ResearchConceptsType 1 diabetesDiabetic ketoacidosisT1D Exchange Clinic RegistryInsulin pump therapyT1D Exchange RegistryContinuous glucose monitoringAcute complicationsGlycemic controlSevere hypoglycemiaClinic registryPump therapyPresent studyDiabetes managementT1D.T1DStudy participantsGlucose monitoringLinear mixed modelsDiabetesRegistryCharacteristics of youthChildrenAdolescentsMixed modelsStatistical comparison
2015
Moving toward the ideal insulin for insulin pumps
Cengiz E, Bode B, Van Name M, Tamborlane WV. Moving toward the ideal insulin for insulin pumps. Expert Review Of Medical Devices 2015, 13: 57-69. PMID: 26560137, DOI: 10.1586/17434440.2016.1109442.Peer-Reviewed Original ResearchConceptsTime-action profileGlycemic controlInsulin formulationsRapid-acting insulin analoguesPhysiologic insulin profilesOptimal glycemic controlInsulin pump therapyNew insulin formulationsQuality of lifeContinuous glucose monitoringRegular insulinPump therapyInsulin profilesPharmacological advancesDiabetes managementInsulin analoguesInsulin absorptionInsulin pumpGlucose monitoringInsulin deliveryPump systemTherapyInsulinDelivery methodsDiabetesCombining glucose monitoring and insulin delivery into a single device: current progress and ongoing challenges of the artificial pancreas
Ang KH, Tamborlane WV, Weinzimer SA. Combining glucose monitoring and insulin delivery into a single device: current progress and ongoing challenges of the artificial pancreas. Expert Opinion On Drug Delivery 2015, 12: 1579-1582. PMID: 26389567, PMCID: PMC4837694, DOI: 10.1517/17425247.2015.1074174.Peer-Reviewed Original ResearchConceptsBurden of careGlucose monitoringInsulin deliveryMultiple hormone systemsOverall glucose levelsType 1 diabetesContinuous glucose monitoringGlycemic targetsSevere hypoglycemiaDiabetes controlInsulin delivery systemsInpatient settingGlucose levelsPharmacokinetic profileOutpatient environmentInsulin analoguesPump suspensionInsulin pumpHypoglycemiaPsychosocial tollHormone systemTarget rangeArtificial pancreasPreliminary findingsCareCurrent State of Type 1 Diabetes Treatment in the U.S.: Updated Data From the T1D Exchange Clinic Registry
Miller KM, Foster NC, Beck RW, Bergenstal RM, DuBose SN, DiMeglio LA, Maahs DM, Tamborlane WV. Current State of Type 1 Diabetes Treatment in the U.S.: Updated Data From the T1D Exchange Clinic Registry. Diabetes Care 2015, 38: 971-978. PMID: 25998289, DOI: 10.2337/dc15-0078.Peer-Reviewed Original ResearchConceptsYears of ageType 1 diabetesT1D Exchange Clinic RegistryContinuous glucose monitoringDiabetic ketoacidosisSevere hypoglycemiaClinic registryMetabolic controlOutcome of treatmentOptimal metabolic controlRegistry findingsAdvanced diabetes technologiesAverage HbA1cMean hemoglobinYounger patientsCommon complicationCurrent treatmentNew therapiesAge 30HbA1cType 1DiabetesGlucose monitoringDiabetes technologyAge
2014
Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia
Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, Hershey T, Cato A, Cheng P, Kollman C, Beck RW, Ruedy K, Aye T, Fox L, Arbelaez AM, Wilson D, Tansey M, Tamborlane W, Peng D, Marzelli M, Winer KK, Reiss AL. Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia. Diabetes 2014, 64: 1770-1779. PMID: 25488901, PMCID: PMC4407847, DOI: 10.2337/db14-1445.Peer-Reviewed Original ResearchConceptsWhite matter growthControl subjectsAge-matched control subjectsType 1 diabetesHigh-resolution structural MRIWhite matter areasWhite matter volumeYoung childrenContinuous glucose monitoringGray matter regionsNondiabetic childrenChronic hyperglycemiaExecutive function scoresFunction scoresGlucose variabilityMatter volumeChildren ages 4Comprehensive neurocognitive testsBrain regionsLongitudinal assessmentType 1Structural MRIHyperglycemiaDiabetesMatter regions
2013
Extended 6-Month Follow-Up of A Randomized Clinical Trial to Assess the Efficacy and Safety of Real-Time Continuous Glucose Monitoring in the Management of Type 1 Diabetes in Young Children Aged 4 to <10 Years
Tansey M, Weinzimer S, Beck R, Ruedy K, Cheng P, Tamborlane W, Kollman C, Mauras N, Fox L, Coffey J, White NH, Group F. Extended 6-Month Follow-Up of A Randomized Clinical Trial to Assess the Efficacy and Safety of Real-Time Continuous Glucose Monitoring in the Management of Type 1 Diabetes in Young Children Aged 4 to <10 Years. Diabetes Care 2013, 36: e63-e63. PMID: 23613604, PMCID: PMC3631880, DOI: 10.2337/dc12-2021.Peer-Reviewed Original ResearchConceptsReal-time continuous glucose monitoringType 1 diabetesContinuous glucose monitoringClinical trialsChildren Aged 4Glucose monitoringAged 4DiabetesFollowTrials