2020
Gastrointestinal Injury Related to Antiangiogenesis Cancer Therapy
Tang T, Abu-Sbeih H, Ma W, Lu Y, Luo W, Foo W, Richards D, Halperin D, Ge P, Wang Y. Gastrointestinal Injury Related to Antiangiogenesis Cancer Therapy. Clinical Colorectal Cancer 2020, 19: e117-e123. PMID: 32284253, DOI: 10.1016/j.clcc.2020.03.002.Peer-Reviewed Original ResearchConceptsAbnormal endoscopic findingsAntiangiogenesis cancer therapyIntensive care unitAntiangiogenesis therapyACD symptomsAntimotility agentsEndoscopic findingsColonic perforationCare unitTertiary care cancer centerActive histologic inflammationRare adverse eventsCancer therapyEnterocolitis symptomsHistologic inflammationNonulcerative inflammationUnderlying malignancyGastrointestinal injuryGastrointestinal toxicityMucosal ulcerationUnderwent endoscopyAdverse eventsMedian durationMost patientsEndoscopic evaluation
2019
Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features – case report and literature review
Luo W, Hofstetter W, Tan D. Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features – case report and literature review. Diagnostic Pathology 2019, 14: 1. PMID: 30621725, PMCID: PMC6323739, DOI: 10.1186/s13000-018-0775-z.Peer-Reviewed Original ResearchConceptsNeoplastic Paneth cellsGastroesophageal junctionCell carcinomaPaneth cellsImmunohistochemical stainsProton pump inhibitor therapySubsequent endoscopic mucosal resectionHER2/neu statusBeta-catenin pathwayUpper gastrointestinal bleedingDiagnosis of adenocarcinomaEndoscopic mucosal resectionHER2/neuPeculiar histologic featuresDistinct staining patternsGastrointestinal bleedingCase presentationAInhibitor therapyClinical courseMucosal resectionHistologic featuresBarrett's esophagusEmergency roomTypical adenocarcinomaSecretory changes
2018
Outcomes of vedolizumab therapy in patients with immune checkpoint inhibitor–induced colitis: a multi-center study
Abu-Sbeih H, Ali F, Alsaadi D, Jennings J, Luo W, Gong Z, Richards D, Charabaty A, Wang Y. Outcomes of vedolizumab therapy in patients with immune checkpoint inhibitor–induced colitis: a multi-center study. Journal For ImmunoTherapy Of Cancer 2018, 6: 142. PMID: 30518410, PMCID: PMC6280383, DOI: 10.1186/s40425-018-0461-4.Peer-Reviewed Original ResearchConceptsMean durationImmune checkpoint inhibitor-induced colitisCheckpoint inhibitor-induced colitisImmune checkpoint inhibitor treatmentAbnormal endoscopic findingsActive histologic inflammationCheckpoint inhibitor treatmentClinical success rateRetrospective case seriesGood safety profileFeatures of chronicityMulti-center studyEndoscopic remissionHistologic inflammationHistologic remissionICI therapyNonulcerative inflammationSteroid therapyVedolizumab infusionsVedolizumab therapyClinical remissionMicroscopic colitisMucosal ulcerationSystemic immunosuppressionAdvanced malignanciesImportance of endoscopic and histological evaluation in the management of immune checkpoint inhibitor-induced colitis
Abu-Sbeih H, Ali F, Luo W, Qiao W, Raju G, Wang Y. Importance of endoscopic and histological evaluation in the management of immune checkpoint inhibitor-induced colitis. Journal For ImmunoTherapy Of Cancer 2018, 6: 95. PMID: 30253811, PMCID: PMC6156850, DOI: 10.1186/s40425-018-0411-1.Peer-Reviewed Original ResearchConceptsEndoscopic featuresClinical outcomesHistologic featuresGrade 3Immune checkpoint inhibitor-induced colitisCheckpoint inhibitor-induced colitisLogistic regressionActive histologic inflammationActive histological inflammationBackgroundImmune checkpoint inhibitorsExtensive colonic involvementMore frequent hospitalizationsMore recurrent symptomsHigh-risk featuresMultivariate logistic regressionSuch adverse eventsTime of onsetHistologic inflammationICPI treatmentCheckpoint inhibitorsColonic involvementEndoscopic inflammationHistological inflammationMucosal ulcerationRecurrent symptoms
2014
Mammary analog secretory carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of literature.
Luo W, Lindley S, Lindley P, Krempl G, Seethala R, Fung K. Mammary analog secretory carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of literature. International Journal Of Clinical And Experimental Pathology 2014, 7: 9008-22. PMID: 25674280, PMCID: PMC4313953.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkers, TumorBiopsyBreast NeoplasmsCarcinomaCranial IrradiationFemaleHumansImmunohistochemistryLymphatic MetastasisMagnetic Resonance ImagingNeoplasm GradingOncogene Proteins, FusionPalatal NeoplasmsPalate, HardRadiotherapy, AdjuvantRecombination, GeneticSalivary Gland NeoplasmsTomography, X-Ray ComputedTreatment OutcomeConceptsHigh-grade histologyMinor salivary glandsETV6-NTRK3 translocationSalivary gland tumorsParotid glandSalivary glandsGrade histologySecretory carcinomaHard palateOriginal tumorGland tumorsCervical lymph node metastasisMammary analogue secretory carcinomaPrimary salivary gland tumorsLow histologic gradeLymph node metastasisLow-grade malignancyAcinic cell carcinomaYears of ageHigh-grade transformationYear old adultsReview of literatureOverall prognosisBenign courseNode metastasis