2018
Auditory and Visual Oddball Stimulus Processing Deficits in Schizophrenia and the Psychosis Risk Syndrome: Forecasting Psychosis Risk With P300
Hamilton HK, Woods SW, Roach BJ, Llerena K, McGlashan TH, Srihari VH, Ford JM, Mathalon DH. Auditory and Visual Oddball Stimulus Processing Deficits in Schizophrenia and the Psychosis Risk Syndrome: Forecasting Psychosis Risk With P300. Schizophrenia Bulletin 2018, 45: 1068-1080. PMID: 30753731, PMCID: PMC6737543, DOI: 10.1093/schbul/sby167.Peer-Reviewed Original ResearchConceptsPsychosis risk syndromeTarget P3bProcessing deficitsPsychosis onsetEvent-related potential componentP300 event-related potential componentTarget P3b amplitudesPsychosis riskInfrequent target stimuliVisual oddball taskPRS participantsHealthy control participantsP3b amplitudeVisual modalityTarget stimuliP3a amplitudeSchizophrenia participantsOddball taskNovel stimuliP300 amplitudeHC participantsRisk syndromeP3bVulnerability markerControl participants
2013
Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity
Perez VB, Woods SW, Roach BJ, Ford JM, McGlashan TH, Srihari VH, Mathalon DH. Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity. Biological Psychiatry 2013, 75: 459-469. PMID: 24050720, PMCID: PMC4028131, DOI: 10.1016/j.biopsych.2013.07.038.Peer-Reviewed Original ResearchConceptsCHR patientsHealthy control subjectsPsychosis onsetControl subjectsClinical high-risk patientsEarly illness schizophrenia patientsPsychosis riskClinical high-risk individualsHigh-risk patientsThird of patientsHigh-risk individualsCurrent clinical criteriaAuditory processing deficitsMismatch negativityNonclinical measuresAuditory devianceCox regressionClinical criteriaUnnecessary treatmentHigh riskCHR convertersPatientsPsychotic disordersSchizophrenia patientsPreventive interventionsCardiovascular mortality in schizophrenia: Defining a critical period for prevention
Srihari VH, Phutane VH, Ozkan B, Chwastiak L, Ratliff JC, Woods SW, Tek C. Cardiovascular mortality in schizophrenia: Defining a critical period for prevention. Schizophrenia Research 2013, 146: 64-68. PMID: 23422728, PMCID: PMC3622848, DOI: 10.1016/j.schres.2013.01.014.Peer-Reviewed Original ResearchConceptsPremature cardiovascular mortalityCardiovascular mortalityCardiovascular riskUrban community mental health centerCommunity mental health centerCardiovascular risk estimatesPrior antipsychotic exposureRace-matched peersCardiovascular risk factorsEarly psychosis clinicMental health centersSuch preventive effortsLow-risk categoryCritical periodAntipsychotic exposureBlood pressureMetabolic syndromeObese categoryPsychosis clinicNormal weightPrimary preventionRisk factorsNational HealthHealth centersNutrition Survey
2012
Obese Schizophrenia Spectrum Patients Have Significantly Higher 10-Year General Cardiovascular Risk and Vascular Ages than Obese Individuals without Severe Mental Illness
Ratliff JC, Palmese LB, Reutenauer EL, Srihari VH, Tek C. Obese Schizophrenia Spectrum Patients Have Significantly Higher 10-Year General Cardiovascular Risk and Vascular Ages than Obese Individuals without Severe Mental Illness. Journal Of The Academy Of Consultation-Liaison Psychiatry 2012, 54: 67-73. PMID: 22664309, PMCID: PMC3435456, DOI: 10.1016/j.psym.2012.03.001.Peer-Reviewed Original ResearchConceptsSevere mental illnessGeneral CVD riskSchizophrenia spectrum patientsVascular ageCVD riskSpectrum patientsNHANES participantsMetabolic riskMental illnessGeneral cardiovascular riskMean vascular ageSystolic blood pressureCardiovascular disease mortalityPrimary care cliniciansHDL cholesterol levelsNutrition Examination SurveyCVD eventsCardiovascular riskObese controlsObese patientsBlood pressureCare cliniciansHypertension treatmentSmoking statusExamination SurveyError Monitoring Dysfunction Across the Illness Course of Schizophrenia
Perez VB, Ford JM, Roach BJ, Woods SW, McGlashan TH, Srihari VH, Loewy RL, Vinogradov S, Mathalon DH. Error Monitoring Dysfunction Across the Illness Course of Schizophrenia. Journal Of Psychopathology And Clinical Science 2012, 121: 372-387. PMID: 22060947, PMCID: PMC3358508, DOI: 10.1037/a0025487.Peer-Reviewed Original ResearchConceptsEarly illness schizophrenia patientsClinical high-risk patientsSchizophrenia patientsIllness courseAge-matched healthy controlsHigh-risk patientsAge-matched HCChronic schizophrenia patientsOnset of psychosisCorrect response negativityPE abnormalitiesRisk patientsCHR patientsClinical prodromeEvent-related potentialsIllness durationHealthy controlsIllness progressionPsychosis onsetPatientsAbnormalitiesIllnessResponse monitoringError-related negativityOnset