1995
Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice
Pieribone VA, Xu Z, Zhang X, Grillner S, Bartfai T, Hökfelt T. Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice. Neuroscience 1995, 64: 861-874. PMID: 7538638, DOI: 10.1016/0306-4522(94)00450-j.Peer-Reviewed Original ResearchConceptsLocus coeruleus neuronsCoeruleus neuronsLocus coeruleusNet outward currentGalanin responseOutward currentsATP-sensitive potassium channelsNorepinephrine-containing locus coeruleus neuronsCoexistence of galaninEffects of galaninPotassium concentrationExtracellular potassium concentrationEndogenous galaninGalanin applicationNormal potassium concentrationGalanin effectsGalanin immunoreactivityBrainstem slicesNorepinephrine neuronsAxonal originLow calcium mediumNeuronal somataSlice preparationImmunohistochemical stainingGalanin
1994
A functional role for nitric oxide in locus coeruleus: immunohistochemical and electrophysiological studies
Xu Z, Pieribone V, Zhang X, Grillner S, Hökfelt T. A functional role for nitric oxide in locus coeruleus: immunohistochemical and electrophysiological studies. Experimental Brain Research 1994, 98: 75-83. PMID: 7516892, DOI: 10.1007/bf00229111.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAmino Acid OxidoreductasesAnimalsArginineElectric StimulationElectrophysiologyEvoked PotentialsHemoglobinsImmunohistochemistryIn Vitro TechniquesLocus CoeruleusMaleMicroscopy, ElectronNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseOmega-N-MethylarginineQuinoxalinesRatsRats, Sprague-DawleySynapsesSynaptic TransmissionTyrosine 3-MonooxygenaseConceptsNeuronal nitric oxideExcitatory postsynaptic potentialsLocus coeruleusNitric oxideFocal electrical stimulationNitric oxide synthaseArginine methyl esterNeuronal cell bodiesRat locus coeruleusNOS inhibitor nitroLC neuronsNG-monomethylLike immunoreactivityNOS inhibitorPostsynaptic potentialsBath applicationOxide synthaseIntracellular recordingsSynaptic transmissionBrain slicesImmunohistochemical analysisElectrophysiological studiesElectrical stimulationAxonal processesCell bodies
1991
Adrenergic innervation of the rat nucleus locus coeruleus arises predominantly from the C1 adrenergic cell group in the rostral medulla
Pieribone VA, Aston-Jones G. Adrenergic innervation of the rat nucleus locus coeruleus arises predominantly from the C1 adrenergic cell group in the rostral medulla. Neuroscience 1991, 41: 525-542. PMID: 1714551, DOI: 10.1016/0306-4522(91)90346-p.Peer-Reviewed Original ResearchChapter 4 Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology
Aston-Jones G, Shipley MT, Chouvet G, Ennis M, van Bockstaele E, Pieribone V, Shiekhattar R, Akaoka H, Drolet G, Astier B, Charléty P, Valentino R, Williams J. Chapter 4 Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology. Progress In Brain Research 1991, 88: 47-75. PMID: 1687622, DOI: 10.1016/s0079-6123(08)63799-1.Peer-Reviewed Original ResearchConceptsLC neuronsLocus coeruleusLC dendritesPericoerulear regionCaudal medullary reticular formationExcitatory amino acid inputsSensory responsesCertain hypothalamic areasLocus coeruleus neuronsNon-NMDA receptorsMedullary reticular formationSingle-pulse stimulationCorticotropin-releasing factorNucleus prepositus hypoglossiDouble-labeling studiesNucleus locus coeruleusVariety of neurotransmittersKölliker-Fuse nucleusMagnesium-free solutionAmino acid inputMinor afferentsPericoerulear areaPerifascicular areasPGi neuronsAdrenergic inhibition
1990
Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in rat
Astier B, Van Bockstaele E, Aston-Jones G, Pieribone V. Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in rat. Neuroscience Letters 1990, 118: 141-146. PMID: 2274260, DOI: 10.1016/0304-3940(90)90612-d.Peer-Reviewed Original ResearchConceptsRostral ventrolateral medullaLocus coeruleusPhenylethanolamine N-methyltransferaseVentrolateral medullaFluoro-GoldNucleus locus coeruleusNon-lesioned animalsNeurons persistC1 neuronsAfferent neuronsAdrenergic inputSuch lesionsLesionsAnatomical evidenceRatsRetrograde transportCoeruleusMedullaNeuronsMultiple pathways
1988
The iontophoretic application of Fluoro-Gold for the study of afferents to deep brain nuclei
Pieribone V, Aston-Jones G. The iontophoretic application of Fluoro-Gold for the study of afferents to deep brain nuclei. Brain Research 1988, 475: 259-271. PMID: 3214735, DOI: 10.1016/0006-8993(88)90614-2.Peer-Reviewed Original ResearchAdrenergic and non-adrenergic neurons in the C1 and C3 areas project to locus coeruleus: A fluorescent double labeling study
Pieribone V, Aston-Jones G, Bohn M. Adrenergic and non-adrenergic neurons in the C1 and C3 areas project to locus coeruleus: A fluorescent double labeling study. Neuroscience Letters 1988, 85: 297-303. PMID: 3362420, DOI: 10.1016/0304-3940(88)90582-4.Peer-Reviewed Original ResearchConceptsLocus coeruleusAfferent neuronsAdrenergic neuronsFluorescent double-labeling studyRetrograde tracer Fluoro-GoldNon-adrenergic neuronsC1 adrenergic neuronsTracer Fluoro-GoldRat locus coeruleusDouble-labeling studiesPhenylethanolamine N-methyltransferaseVentrolateral medullaDorsomedial medullaFluoro-GoldIontophoretic injectionNeuronsSubsequent immunofluorescenceCoeruleusMedullaAreas project
1986
The Brain Nucleus Locus Coeruleus: Restricted Afferent Control of a Broad Efferent Network
Aston-Jones G, Ennis M, Pieribone V, Nickell W, Shipley M. The Brain Nucleus Locus Coeruleus: Restricted Afferent Control of a Broad Efferent Network. Science 1986, 234: 734-737. PMID: 3775363, DOI: 10.1126/science.3775363.Peer-Reviewed Original ResearchConceptsLocus coeruleusWheat germ agglutinin conjugated horseradish peroxidaseParaventricular hypothalamic nucleusNucleus locus coeruleusConjugated horseradish peroxidaseMinor afferentsAfferent neuronsRetrograde labelingHypothalamic nucleiIntermediate grayElectrophysiologic experimentsFocal injectionsPrepositus hypoglossiRostral medullaDorsal capAfferent controlBrain nucleiCoeruleusEfferent networkBrain regionsAnatomic organizationAbsence of inputParagigantocellularisAfferentsHypoglossi