2000
Multiple messengers in descending serotonin neurons: localization and functional implications
Hökfelt T, Arvidsson U, Cullheim S, Millhorn D, Nicholas A, Pieribone V, Seroogy K, Ulfhake B. Multiple messengers in descending serotonin neurons: localization and functional implications. Journal Of Chemical Neuroanatomy 2000, 18: 75-86. PMID: 10708921, DOI: 10.1016/s0891-0618(99)00037-x.Peer-Reviewed Original ResearchConceptsGamma-amino butyric acidSerotonin neuronsInhibitory neurotransmitter gamma-amino butyric acidNeurotransmitter gamma-amino butyric acidRaphe serotonin neuronsPost-synaptic actionsParticular substance PNumber of neuropeptidesSerotonin projectionsDorsal hornVentral hornSubstance PSpinal cordSame neuronsRostral levelsSuch neuronsNeuronsEnzyme glutaminasePresent review articleGlutamateRecent studiesReview articleFunctional implicationsWide spectrumHorn
1995
Synaptic Vesicle Depletion in Reticulospinal Axons is Reduced by 5‐hydroxytryptamine: Direct Evidence for Presynaptic Modulation of Glutamatergic Transmission
Shupliakov O, Pieribone VA, Gad H, Brodin L. Synaptic Vesicle Depletion in Reticulospinal Axons is Reduced by 5‐hydroxytryptamine: Direct Evidence for Presynaptic Modulation of Glutamatergic Transmission. European Journal Of Neuroscience 1995, 7: 1111-1116. PMID: 7613617, DOI: 10.1111/j.1460-9568.1995.tb01099.x.Peer-Reviewed Original ResearchConceptsReticulospinal axonsPresynaptic Ca2Glutamatergic synaptic transmissionSynaptic glutamate releaseSynaptic vesiclesIntra-axonal recordingsGiant reticulospinal axonsSynaptic vesicle clustersGlutamatergic transmissionPresynaptic modulationGlutamate releaseSpinal cordPresynaptic elementsSynaptic transmissionAction potential stimulationSynaptic vesicle depletionSame axonVesicle depletionAxonsMarked reductionNumber of vesiclesPotential stimulationSynaptic exocytosisActive zoneCa2
1994
Distribution of alpha 1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes
Pieribone V, Nicholas A, Dagerlind A, Hokfelt T. Distribution of alpha 1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes. Journal Of Neuroscience 1994, 14: 4252-4268. PMID: 8027777, PMCID: PMC6577046, DOI: 10.1523/jneurosci.14-07-04252.1994.Peer-Reviewed Original ResearchConceptsAlpha 1A/DSpinal motor nucleiSpinal cordCerebral cortexMotor nucleusAmygdaloid nucleusLight labellingCA1-CA4 regionsAlpha-1 adrenoceptorsAlpha 1B-adrenoceptorsIntermediolateral cell columnInternal plexiform layerLateral amygdaloid nucleusReticular thalamic nucleusDistribution of neuronsMedullary raphe nucleiMedullary reticular formationCentral amygdaloid nucleusLateral hypothalamic nucleusInferior olivary nucleusReceptor distribution patternsSubtype-specific probesAdrenoceptor mRNANoradrenergic innervationAdrenoceptor subtypesNeuropeptide role of both peptide YY and neuropeptide Y in vertebrates suggested by abundant expression of their mRNAS in a cyclostome brain
Söderberg C, Pieribone VA, Dahlstrand J, Brodin L, Larhammar D. Neuropeptide role of both peptide YY and neuropeptide Y in vertebrates suggested by abundant expression of their mRNAS in a cyclostome brain. Journal Of Neuroscience Research 1994, 37: 633-640. PMID: 8028041, DOI: 10.1002/jnr.490370510.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBrainDNA, ComplementaryGene Expression RegulationHumansIn Situ HybridizationIntestinal MucosaLampreysMolecular Sequence DataNeuropeptide YOrgan SpecificityPeptide BiosynthesisPeptide YYPeptidesPhylogenyRNA, MessengerSequence HomologySpecies SpecificityVertebratesImmunohistochemical analysis of the relation between 5‐hydroxytryptamine‐ and neuropeptide‐immunoreactive elements in the spinal cord of an amphibian (Xenopus laevis)
Pieribone V, Brodin L, Hökfelt T. Immunohistochemical analysis of the relation between 5‐hydroxytryptamine‐ and neuropeptide‐immunoreactive elements in the spinal cord of an amphibian (Xenopus laevis). The Journal Of Comparative Neurology 1994, 341: 492-506. PMID: 7515401, DOI: 10.1002/cne.903410406.Peer-Reviewed Original ResearchConceptsCalcitonin gene-related peptidePeptide-immunoreactive fibersCorticotropin-releasing factorSubstance PSpinal cordImmunoreactive fibersXenopus laevis spinal cordCCK-immunoreactive fibersGene-related peptideCRF-immunoreactive fibersLabeling of fibersDouble-labeling techniqueGAL immunoreactivitySpinal transectionPeptide immunoreactivityImmunohistochemical analysisGalaninImmunohistochemical dataRostrocaudal levelsCordIntact animalsSimilar negative resultsImmunoreactive materialImmunofluorescence double-labeling techniqueCholecystokinin
1993
Cellular localization of messenger RNA for beta-1 and beta-2 adrenergic receptors in rat brain: An in situ hybridization study
Nicholas AP, Pieribone VA, Hökfelt T. Cellular localization of messenger RNA for beta-1 and beta-2 adrenergic receptors in rat brain: An in situ hybridization study. Neuroscience 1993, 56: 1023-1039. PMID: 8284033, DOI: 10.1016/0306-4522(93)90148-9.Peer-Reviewed Original ResearchConceptsSpinal cordRat brainCentral nervous system circuitryBeta 1Messenger RNABeta-receptor subtypesThalamic intralaminar nucleiAnterior olfactory nucleusBeta 1 receptorsIntermediate gray matterReticular thalamic nucleusMedullary reticular formationNervous system circuitryReceptor messenger RNABeta 1 messenger RNABeta-2 adrenergic receptorsCentral nervous systemRat beta 1Selective labeling patternsDeep cerebellar nucleiUnfixed rat brainOlfactory nucleusTrapezoid nucleusCerebral cortexSitu hybridization studiesDistributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study
Nicholas A, Pieribone V, Hökfelt T. Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study. The Journal Of Comparative Neurology 1993, 328: 575-594. PMID: 8381444, DOI: 10.1002/cne.903280409.Peer-Reviewed Original ResearchConceptsCentral nervous systemNervous systemCerebral cortexSpinal cordReceptor subtypesRat brainAlpha-2 adrenergic receptor subtypesVentrolateral medullary reticular formationRat central nervous systemAlpha-2 receptor subtypesMRNA labelingAlpha 2 receptorsIntermediolateral cell columnThoracic spinal cordNucleus tractus solitariiReticular thalamic nucleusHypothalamic paraventricular nucleusMedullary reticular formationDorsal root gangliaIslands of CallejaAdrenergic receptor subtypesSelective labeling patternsDeep cerebellar nucleiAlpha 2 probeRat alpha-2ACGRP-like immunoreactivity in A11 dopamine neurons projecting to the spinal cord and a note on CGRP-CCK cross-reactivity
Orazzo C, Pieribone V, Ceccatelli S, Terenius L, Hökfelt T. CGRP-like immunoreactivity in A11 dopamine neurons projecting to the spinal cord and a note on CGRP-CCK cross-reactivity. Brain Research 1993, 600: 39-48. PMID: 8422589, DOI: 10.1016/0006-8993(93)90399-8.Peer-Reviewed Original ResearchConceptsCGRP antiserumSpinal cordRat brainCalcitonin gene-related peptideDopamine cell groupsCGRP-like immunoreactivityGene-related peptideIndirect immunofluorescence techniqueLike immunoreactivityDopamine neuronsBrain areasDouble-labeling procedureImmunofluorescence techniqueCell groupsCholecystokininCatecholamine groupsCordImmunohistochemistryImmunoreactivityNeuronsRadioimmunoassayBrainPresent studyTerminal portionAntiserum
1992
Differential expression of mRNAs for neuropeptide Y-related peptides in rat nervous tissues: possible evolutionary conservation
Pieribone V, Brodin L, Friberg K, Dahlstrand J, Soderberg C, Larhammar D, Hokfelt T. Differential expression of mRNAs for neuropeptide Y-related peptides in rat nervous tissues: possible evolutionary conservation. Journal Of Neuroscience 1992, 12: 3361-3371. PMID: 1527583, PMCID: PMC6575750, DOI: 10.1523/jneurosci.12-09-03361.1992.Peer-Reviewed Original ResearchConceptsNeuropeptide YPeripheral nerve gangliaRat nervous tissuePopulations of neuronsBrainstem neuronsNPY mRNASympathetic gangliaAdrenal glandCaudal medullaCNS neuronsSpinal cordRostral medullaNerve gangliaRat CNSRat brainVisceral organsMammalian CNSPYY mRNANervous tissuePYY immunoreactivityEndocrine cellsPP mRNAPYYNeuronsMidline regionSerotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate
Nicholas AP, Pieribone VA, Arvidsson U, Hökfelt T. Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate. Neuroscience 1992, 48: 545-559. PMID: 1376453, DOI: 10.1016/0306-4522(92)90401-m.Peer-Reviewed Original ResearchConceptsAspartate-like immunoreactivityExcitatory amino acidsSubstance PColchicine-treated ratsSpinal cordLarger alpha motor neuronsB3 cell groupSubstance P neuronsAlpha motor neuronsGlutamate-like immunoreactivityTripeptide thyrotropin-releasing hormoneDistribution of serotoninThyrotropin-releasing hormoneUndecapeptide substance PImmunohistofluorescence techniqueMedullary neuronsImmunoreactive neuronsRaphe neuronsVentral hornRetrograde tracingSerotonergic neuronsMedulla oblongataSpinal projectionsLarge boutonsAutonomic cells
1991
Initial observations on the localization of mRNA for α and β adrenergic receptors in brain and peripheral tissues of rat using in situ hybridization
Nicholas A, Pieribone V, Elde R, Hökfelt T. Initial observations on the localization of mRNA for α and β adrenergic receptors in brain and peripheral tissues of rat using in situ hybridization. Molecular And Cellular Neuroscience 1991, 2: 344-350. PMID: 19912818, DOI: 10.1016/1044-7431(91)90065-v.Peer-Reviewed Original ResearchCerebral cortexAdrenergic receptorsSpinal gray matterMedullary raphe nucleiDorsal root gangliaBeta-adrenergic receptorsLocation of alphaPrevious autoradiographic studiesSelective labeling patternsRaphe nucleusBasal gangliaRoot gangliaPeripheral organsSpinal cordPeripheral tissuesSpecific radioligandHippocampal formationAdrenal medullaCerebellar cortexPharmacological manipulationGray matterAutoradiographic studyKidneyBrainCortex