1987
Decreasing Risk of Leukemia with Prolonged Follow-up after Chemotherapy and Radiotherapy for Hodgkin's Disease
Blayney D, Longo D, Young R, Greene M, Hubbard S, Postal M, Duffey P, DeVita V. Decreasing Risk of Leukemia with Prolonged Follow-up after Chemotherapy and Radiotherapy for Hodgkin's Disease. New England Journal Of Medicine 1987, 316: 710-714. PMID: 3821809, DOI: 10.1056/nejm198703193161203.Peer-Reviewed Original ResearchConceptsRisk of leukemiaHodgkin's diseaseAcute leukemiaNormal marrow morphologyBone marrow aspirationAcute nonlymphocytic leukemiaSecond neoplasmsMarrow aspirationNonlymphocytic leukemiaMarrow morphologyActuarial analysisPatientsBone marrowFirst treatmentPeak onsetLeukemiaMorphologic changesChemotherapyRadiation treatmentDiseaseComplicationsTreatmentRiskYearsPrevious studies
1979
CNS Infiltration: A Complication of Diffuse Lymphomas
Young R, Howser D, Anderson T, Jaffe E, DeVita V. CNS Infiltration: A Complication of Diffuse Lymphomas. 1979, 121-130. DOI: 10.1007/978-1-349-04285-2_11.Peer-Reviewed Original ResearchCentral nervous systemHistological patternVaried histological patternsHigh-risk populationDiffuse histological patternVaried natural historyCNS complicationsCNS recurrenceNeurological complicationsProphylactic therapySerious complicationsLymphomatous involvementRappaport classificationHodgkin's lymphomaSuccessful therapyHigh riskDistinct histologyNervous systemDiffuse lymphomaComplications
1978
Chemotherapy (cyclophosphamide, vincristine, and prednisone) versus radiotherapy (total body irradiation) for stage III-IV poorly differentiated lymphocytic lymphoma.
Johnson R, Canellos G, Young R, Chabner B, DeVita V. Chemotherapy (cyclophosphamide, vincristine, and prednisone) versus radiotherapy (total body irradiation) for stage III-IV poorly differentiated lymphocytic lymphoma. Journal Of The National Cancer Institute 1978, 62: 321-5. PMID: 580598.Peer-Reviewed Original ResearchConceptsTotal body irradiationTotal body irradiation patientsEvaluate new therapeutic approachesSurvival rateStage III-IVCandida sepsisDurable remissionsLymphocytic lymphomaBody irradiationMalignant lymphomaSevere granulocytopeniaMyeloproliferative disordersLate complicationsIII-IVChemotherapy complicationsInduction treatmentSurvival advantageNeurotoxic reactionsTherapeutic approachesLymphomaChemotherapyPatientsComplicationsRadiotherapySurvival
1977
The treatment of Hodgkin's disease
Young R, Anderson T, DeVita V. The treatment of Hodgkin's disease. Current Problems In Cancer 1977, 1: 1-29. PMID: 66119, DOI: 10.1016/s0147-0272(77)80009-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultBleomycinBone MarrowChildClinical Trials as TopicDrug Therapy, CombinationFemaleHodgkin DiseaseHumansLaparoscopyLaparotomyLiverLymph NodesMaleMechlorethamineNational Institutes of Health (U.S.)Neoplasms, Multiple PrimaryPrednisoneProcarbazineRadiotherapy, High-EnergySpleenSplenectomyUnited StatesVincristine
1976
Treatment of hodgkin's disease using intensive chemotherapy followed by irradiation
Kun L, Devita V, Young R, Johnson R. Treatment of hodgkin's disease using intensive chemotherapy followed by irradiation. International Journal Of Radiation Oncology • Biology • Physics 1976, 1: 619-626. PMID: 824248, DOI: 10.1016/0360-3016(76)90143-7.Peer-Reviewed Original ResearchConceptsHodgkin's diseaseResidual Hodgkin's diseaseTreatment-related morbidityUntreated Hodgkin's diseaseNormal tissue reactionsIntensive chemotherapyMarginal recurrenceCombination chemotherapyIncreased incidenceAutopsy examinationRadiation therapyTherapeutic efficacyFull doseMedical CollegeDiseasePatientsTissue reactionChemotherapyMarked enhancementIrradiation fieldMorbidityComplicationsRecurrenceTherapyIncidence
1975
Osteonecrosis of the femoral head in patients with lymphoma treated with intermittent combination chemotherapy (including corticosteroids)
Ihde D, Devita V. Osteonecrosis of the femoral head in patients with lymphoma treated with intermittent combination chemotherapy (including corticosteroids). Cancer 1975, 36: 1585-1588. PMID: 1192349, DOI: 10.1002/1097-0142(197511)36:5<1585::aid-cncr2820360508>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsCombination chemotherapyFemoral headHigh-dose prednisoneIntermittent combination chemotherapyWeeks of therapyInitiation of therapyLong-term complicationsNecrosis of boneSteroid administrationAdult patientsMalignant lymphomaPatientsChemotherapyLymphomaOsteonecrosisComplicationsTherapyPrednisoneVincristineNecrosisHeadAdministrationWeeksMonths
1974
Thrombocytosis in Chronic Granulocytic Leukemia: Incidence and Clinical Significance
Mason J, DeVita V, Canellos G. Thrombocytosis in Chronic Granulocytic Leukemia: Incidence and Clinical Significance. Blood 1974, 44: 483-487. PMID: 4528824, DOI: 10.1182/blood.v44.4.483.483.Peer-Reviewed Original ResearchConceptsChronic granulocytic leukemiaPlatelet countGranulocytic leukemiaClinical significanceOccurrence of thrombocytosisElevated platelet countThrombohemorrhagic complicationsUntreated patientsMedian durationShorter survivalBlastic crisisNormal countsPatientsSubsequent courseThrombocytosisLeukemiaCountEntire courseGroupCourseComplicationsClinicIncidenceDiagnosis
1973
MAINTENANCE CHEMOTHERAPY FOR ADVANCED HODGKIN'S DISEASE IN REMISSION
Young R, Chabner B, Canellos G, Schein P, Devita V. MAINTENANCE CHEMOTHERAPY FOR ADVANCED HODGKIN'S DISEASE IN REMISSION. The Lancet 1973, 301: 1339-1343. PMID: 4122739, DOI: 10.1016/s0140-6736(73)91672-3.Peer-Reviewed Original ResearchConceptsMaintenance therapyIntermittent therapyAdvanced HodgkinMaintenance chemotherapyAdditional therapyComplete remissionInitial remissionMedian durationFurther therapyHodgkin's diseasePatientsTherapyRemissionEntire groupDiseaseChemotherapySignificant differencesSurvivalGroupPrednisoneRegimensComplicationsMustineVincristineInfection
1970
Löffler's Syndrome as a Complication of Bipedal Lymphangiography
Bray D, Brown C, Herdt J, DeVita V. Löffler's Syndrome as a Complication of Bipedal Lymphangiography. JAMA 1970, 214: 369-371. PMID: 5469078, DOI: 10.1001/jama.1970.03180020087020.Peer-Reviewed Original Research