2020
trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder
Yuan Y, Zhen L, Li Z, Xu W, Leng H, Xu W, Zheng V, Luria V, Pan J, Tao Y, Zhang H, Cao S, Xu Y. trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder. Journal Of Psychopharmacology 2020, 34: 726-736. PMID: 32308103, DOI: 10.1177/0269881120914221.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) expressionPhosphorylated cAMP response elementAnxiety-like behaviorNeurotrophic factor expressionNeuropathic painCAMP response elementBrain-derived neurotrophic factor levelsGlucocorticoid receptorFactor expressionProlonged stressStress-induced anxiety-like behaviorStress disorderCold allodynia testsNeurotrophic factor levelsAdrenal axis functionPain-related regionsLocomotor activity testSerum corticosterone levelsMarble burying testNumber of marblesProtein kinase APost-traumatic stress disorderEnzyme-linked immunosorbentClassical animal modelsResponse element
2018
Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior
Huang X, Xiaokaiti Y, Yang J, Pan J, Li Z, Luria V, Li Y, Song G, Zhu X, Zhang H, O'Donnell J, Xu Y. Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior. Neuropharmacology 2018, 143: 176-185. PMID: 30268520, DOI: 10.1016/j.neuropharm.2018.09.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsAnxiety DisordersCell LineCorticosteroneCyclic Nucleotide Phosphodiesterases, Type 2Depressive DisorderDose-Response Relationship, DrugHippocampusImidazolesMaleMice, Inbred ICRNADPH Oxidase 2NADPH OxidasesNeuronsOxidative StressPhosphodiesterase InhibitorsPsychotropic DrugsReactive Oxygen SpeciesTriazinesConceptsAnxiolytic-like effectsBAY 60Oxidative stressNADPH oxidase inhibitor apocyninPDE2 inhibitor Bay 60Prevalence of depressionOxidase inhibitor apocyninPhosphodiesterase 2Stress-related depressionAnxiety-like behaviorSource of ROSBDNF levelsNeuroprotective mechanismsStressed miceInhibitor apocyninCAMP/cGMPNADPH subunitsBehavioral abnormalitiesGp91phox expressionAntioxidant strategiesPDE2 inhibitionAntioxidant defenseDepressionGp91phoxVivo tests